ID   DHAQ_GLUPO              Reviewed;         773 AA.
AC   P17201;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Membrane-bound aldehyde dehydrogenase [pyrroloquinoline-quinone];
DE            Short=ALDH;
DE            EC=1.2.5.2;
DE   Flags: Precursor;
OS   Gluconacetobacter polyoxogenes (Acetobacter polyoxogenes).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Gluconacetobacter.
OX   NCBI_TaxID=439;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 45-60 AND
RP   480-490.
RC   STRAIN=NBI1028;
RX   PubMed=2606906; DOI=10.1093/oxfordjournals.jbchem.a122889;
RA   Tamaki T., Horinouchi S., Fukaya M., Okumura H., Kawamura Y., Beppu T.;
RT   "Nucleotide sequence of the membrane-bound aldehyde dehydrogenase gene from
RT   Acetobacter polyoxogenes.";
RL   J. Biochem. 106:541-544(1989).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a quinone + an aldehyde + H2O = a carboxylate + a quinol +
CC         H(+); Xref=Rhea:RHEA:13881, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:24646, ChEBI:CHEBI:29067,
CC         ChEBI:CHEBI:132124; EC=1.2.5.2;
CC   -!- COFACTOR:
CC       Name=pyrroloquinoline quinone; Xref=ChEBI:CHEBI:58442;
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein.
CC   -!- PTM: Predicted to be exported by the Tat system. The position of the
CC       signal peptide cleavage has been experimentally proven.
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DR   EMBL; D00521; BAA00408.1; -; Genomic_DNA.
DR   PIR; JU0135; JU0135.
DR   AlphaFoldDB; P17201; -.
DR   SMR; P17201; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0047113; F:aldehyde dehydrogenase (quinone) activity; IEA:UniProtKB-EC.
DR   InterPro; IPR000674; Ald_Oxase/Xan_DH_a/b.
DR   InterPro; IPR008274; AldOxase/xan_DH_Mopterin-bd.
DR   InterPro; IPR037165; AldOxase/xan_DH_Mopterin-bd_sf.
DR   InterPro; IPR012368; OxRdtase_Mopterin-bd_su_IorB.
DR   InterPro; IPR006311; TAT_signal.
DR   Pfam; PF02738; Ald_Xan_dh_C2; 3.
DR   PIRSF; PIRSF036389; IOR_B; 1.
DR   SMART; SM01008; Ald_Xan_dh_C; 1.
DR   SUPFAM; SSF56003; SSF56003; 2.
DR   PROSITE; PS51318; TAT; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Direct protein sequencing; Membrane;
KW   Oxidoreductase; PQQ; Signal.
FT   SIGNAL          1..44
FT                   /note="Tat-type signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00648,
FT                   ECO:0000269|PubMed:2606906"
FT   CHAIN           45..773
FT                   /note="Membrane-bound aldehyde dehydrogenase
FT                   [pyrroloquinoline-quinone]"
FT                   /id="PRO_0000025582"
SQ   SEQUENCE   773 AA;  84249 MW;  93A76757B3B054FC CRC64;
     MGRLNRFRLG KDGRREQASL SRRGFLVTSL GAGVMFGFAR PSSANQIFPL DRSLPGDGAF
     EPTIWCSIAP DGEITVNIIR AEMGQHIGTA LARIIADEME ADWSKVRINY VDTDPKWGLM
     VTGGSWSVWM TWDVFRQAGA ATRTAMVEEG ARLLGTTPDK CTVASSIVSA GGKQISFGDI
     VAKGHPSHAF TPEEMAKLPL KPASERRLIG NAELKALDIP AKTNGTAIYG IDAKVEGMLY
     GRPKMPPTRY GSKVRSVDDT EAKKIKGYVR YLLIDDPSQV VQGWVVVLAE SYSAAIRATD
     ALKVEWTPGE TIHTSERDIQ DRGRELINNK AGGVYIFNDD GVDQAFGSAH TVMDQEYTCA
     SVLHYQLEPT NALAFEKDGV YEIHAGNQWQ SLILPTLAKS LQVPESKVIL RSYLLGGGFG
     RRLNGDYMIP AALASKALGG KPVKLILTRS DDMQFDSFRS PSVQRVRMAF DASDRITAMD
     YQAAAGWPTG VMAEAFMEKG VDGKPYDQFA IAGGDHWYEV GAFRVRALRN DLAEKTFRPG
     WLRSVSPGWT SWGVECFLDE VAHRQKKDPA QFRLELLTGQ GRNKGQAPDS VGGALRQAAV
     VRRLMEKVNW GKTSLPKDTA MGLATTAGQE RGMPTWDRCV AQVHVDRSTG VVTCQKLTIL
     VDAGTVVDPD GAKAQTEGAA LWGLSMVLFE NTEIVNGMPV DRNLNTYTPL RIADTPEMDI
     EFLPSTEKPM GLGEPGTTVV GPAIGNAIFN AVGVRLRHMP VRPADVLRGL QNG