DHB11_RAT
ID DHB11_RAT Reviewed; 298 AA.
AC Q6AYS8;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Estradiol 17-beta-dehydrogenase 11;
DE EC=1.1.1.62 {ECO:0000250|UniProtKB:Q9EQ06};
DE AltName: Full=17-beta-hydroxysteroid dehydrogenase 11;
DE Short=17-beta-HSD 11;
DE Short=17bHSD11;
DE Short=17betaHSD11;
DE AltName: Full=17-beta-hydroxysteroid dehydrogenase XI;
DE Short=17-beta-HSD XI;
DE Short=17betaHSDXI;
DE AltName: Full=Dehydrogenase/reductase SDR family member 8;
DE Flags: Precursor;
GN Name=Hsd17b11; Synonyms=Dhrs8;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to
CC androsterone in vitro, suggesting that it may participate in androgen
CC metabolism during steroidogenesis. May act by metabolizing compounds
CC that stimulate steroid synthesis and/or by generating metabolites that
CC inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-
CC dione (4-androste-3,17-dione), and only a slight activity toward
CC testosterone to A-dione. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH;
CC Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469,
CC ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62;
CC Evidence={ECO:0000250|UniProtKB:Q9EQ06};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=17beta-estradiol + NADP(+) = estrone + H(+) + NADPH;
CC Xref=Rhea:RHEA:24616, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469,
CC ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.62;
CC Evidence={ECO:0000250|UniProtKB:Q9EQ06};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000250|UniProtKB:Q9EQ06}. Lipid droplet
CC {ECO:0000250|UniProtKB:Q9EQ06}. Note=Redistributed from the endoplasmic
CC reticulum to lipids droplets in the cell upon induction of lipids
CC droplet formation. {ECO:0000250|UniProtKB:Q9EQ06}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. 17-beta-HSD 3 subfamily. {ECO:0000305}.
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DR EMBL; BC078929; AAH78929.1; -; mRNA.
DR RefSeq; NP_001004209.1; NM_001004209.1.
DR RefSeq; XP_006250689.1; XM_006250627.3.
DR RefSeq; XP_006250691.1; XM_006250629.3.
DR RefSeq; XP_017454586.1; XM_017599097.1.
DR AlphaFoldDB; Q6AYS8; -.
DR SMR; Q6AYS8; -.
DR STRING; 10116.ENSRNOP00000003004; -.
DR jPOST; Q6AYS8; -.
DR PaxDb; Q6AYS8; -.
DR PRIDE; Q6AYS8; -.
DR Ensembl; ENSRNOT00000003004; ENSRNOP00000003004; ENSRNOG00000002210.
DR GeneID; 289456; -.
DR KEGG; rno:289456; -.
DR CTD; 51170; -.
DR RGD; 1303235; Hsd17b11.
DR eggNOG; KOG1201; Eukaryota.
DR GeneTree; ENSGT00940000160856; -.
DR HOGENOM; CLU_010194_2_5_1; -.
DR InParanoid; Q6AYS8; -.
DR OMA; RTPMIKM; -.
DR OrthoDB; 1373099at2759; -.
DR PhylomeDB; Q6AYS8; -.
DR TreeFam; TF312837; -.
DR Reactome; R-RNO-193144; Estrogen biosynthesis.
DR PRO; PR:Q6AYS8; -.
DR Proteomes; UP000002494; Chromosome 14.
DR Bgee; ENSRNOG00000002210; Expressed in jejunum and 20 other tissues.
DR Genevisible; Q6AYS8; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005811; C:lipid droplet; IBA:GO_Central.
DR GO; GO:0044594; F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity; IEA:RHEA.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0016229; F:steroid dehydrogenase activity; ISO:RGD.
DR GO; GO:0006710; P:androgen catabolic process; ISO:RGD.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Lipid biosynthesis; Lipid droplet; Lipid metabolism;
KW NADP; Oxidoreductase; Reference proteome; Signal; Steroid biosynthesis.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..298
FT /note="Estradiol 17-beta-dehydrogenase 11"
FT /id="PRO_0000031973"
FT ACT_SITE 185
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 40..64
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 172
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 298 AA; 32938 MW; 51D6D1D30068B398 CRC64;
MKYLLDLILL LPLLIVFCIE SFIKRLIPKK KKSVAGEIVL ITGAGHGIGR LTAYEFAKLN
TKLVLWDINK NGIEETAAKC RKLGAQVHPF VVDCSQREEI YSAVRKVKEE VGDVSILVNN
AGVVYTADLF ATQDPQIEKT FEVNVLAHFW TTKAFLPAMM KNNHGHVVTV ASAAGHTVVP
FLLAYCSSKF AAVGFHRALT DELAALGCTG VRTSCLCPNF INTGFIKNPS TNLGPTLEPE
EVVEHLMHGI LTNQKMIFVP GSIALLTVLE RVFPERFLDV LKRRINVKFD AVVGYKDK
