ID   ADAD1_RAT               Reviewed;         619 AA.
AC   Q3KR54;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Adenosine deaminase domain-containing protein 1;
DE   AltName: Full=Testis nuclear RNA-binding protein;
GN   Name=Adad1; Synonyms=Tenr;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for male fertility and normal male germ cell
CC       differentiation (By similarity). Plays a role in spermatogenesis (By
CC       similarity). Binds to RNA but not to DNA (By similarity).
CC       {ECO:0000250|UniProtKB:Q5SUE7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5SUE7}.
CC   -!- SIMILARITY: Belongs to the ADAD family. {ECO:0000305}.
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DR   EMBL; BC105906; AAI05907.1; -; mRNA.
DR   RefSeq; NP_001006978.2; NM_001006977.2.
DR   AlphaFoldDB; Q3KR54; -.
DR   SMR; Q3KR54; -.
DR   STRING; 10116.ENSRNOP00000023282; -.
DR   PaxDb; Q3KR54; -.
DR   PRIDE; Q3KR54; -.
DR   GeneID; 294979; -.
DR   KEGG; rno:294979; -.
DR   UCSC; RGD:1359309; rat.
DR   CTD; 132612; -.
DR   RGD; 1359309; Adad1.
DR   VEuPathDB; HostDB:ENSRNOG00000017246; -.
DR   eggNOG; KOG2777; Eukaryota.
DR   InParanoid; Q3KR54; -.
DR   OMA; EKMSGNN; -.
DR   OrthoDB; 947117at2759; -.
DR   PhylomeDB; Q3KR54; -.
DR   TreeFam; TF315806; -.
DR   PRO; PR:Q3KR54; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000017246; Expressed in testis and 1 other tissue.
DR   ExpressionAtlas; Q3KR54; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IBA:GO_Central.
DR   GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; ISO:RGD.
DR   GO; GO:0008251; F:tRNA-specific adenosine deaminase activity; IBA:GO_Central.
DR   GO; GO:0006382; P:adenosine to inosine editing; IBA:GO_Central.
DR   GO; GO:0006396; P:RNA processing; IBA:GO_Central.
DR   GO; GO:0007286; P:spermatid development; ISS:UniProtKB.
DR   CDD; cd19905; DSRM_ADAD1; 1.
DR   InterPro; IPR002466; A_deamin.
DR   InterPro; IPR044455; ADAD1_DSRM.
DR   InterPro; IPR014720; dsRBD_dom.
DR   Pfam; PF02137; A_deamin; 1.
DR   Pfam; PF00035; dsrm; 1.
DR   SMART; SM00552; ADEAMc; 1.
DR   SMART; SM00358; DSRM; 1.
DR   PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Nucleus; Reference proteome;
KW   RNA-binding; Spermatogenesis.
FT   CHAIN           1..619
FT                   /note="Adenosine deaminase domain-containing protein 1"
FT                   /id="PRO_0000309522"
FT   DOMAIN          138..206
FT                   /note="DRBM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   DOMAIN          291..617
FT                   /note="A to I editase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00240"
FT   REGION          28..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   619 AA;  67816 MW;  0580AB1A80F88707 CRC64;
     MATAGGSRRA PVPGPRLGLP LAAHLPASLG GEGAKDSLGG EKTSGNNDWF QSSRVPSFAQ
     MLKKNLPVQS SAQTVTLPTG YSSESCSLSN MASKVTQVTG NFPEPLLSKG LSSISNPVLP
     PKKIPKEFIM KYRRGEINPV SALHQFAQMQ RVQLDLKETV TTGNVMGPYF AFCAVVDGIQ
     YKTGLGQNKK ESRSNAAKLA LDELLQLDEP EPRALEPAGP PPIPAEPIVT PEAAYISKVQ
     YEGRQVQYAK ISQLVKETFS QLISSHSQYL KCSSSLAAFI IERGGHHEVV AIGTGEYNYS
     QCIKPNGRVL HDTHAVVTAR RSLLRYFYRQ LLLFYSKNPA MMEKSIFCTE PASNLLTLKQ
     NINLYLYMNQ LPKGSAQIKS QLRLNPHSIS AFEANEELSL HVAVEGKIYL TVYCSADGVN
     RVNSMSSSDK LTRWEVLGVQ GALLSHFIQP VYISSILVGD GNCNDTRGLE IAINQRVDDA
     LTSKLPMFYL VNRPHISLVP TAYPLQINLD HKSLSLNWAQ GDNSLEIVDG LSGKITESSP
     FKSGLSMASR LCKAAMLSRF NLLAKEAKTD DLLEARTYHA AKCLSGPYQE AKALLKAYLQ
     QHGYGSWIVK SPCIEQFSM