DHB13_HUMAN
ID DHB13_HUMAN Reviewed; 300 AA.
AC Q7Z5P4; A8K9R9; Q2M1L5; Q86W22; Q86W23;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=17-beta-hydroxysteroid dehydrogenase 13;
DE Short=17-beta-HSD 13;
DE EC=1.1.-.-;
DE AltName: Full=Short chain dehydrogenase/reductase family 16C member 3;
DE AltName: Full=Short-chain dehydrogenase/reductase 9;
DE Flags: Precursor;
GN Name=HSD17B13; Synonyms=SCDR9, SDR16C3; ORFNames=HMFN0376, UNQ497/PRO1014;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RA Zhong H., Wang R.;
RT "Molecular cloning and expression of a novel and tissue specific 17-beta
RT hydroxysteroid dehydrogenase.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RC TISSUE=Liver;
RX PubMed=17311113;
RA Liu S., Huang C., Li D., Ren W., Zhang H., Qi M., Li X., Yu L.;
RT "Molecular cloning and expression analysis of a new gene for short-chain
RT dehydrogenase/reductase 9.";
RL Acta Biochim. Pol. 54:213-218(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Hepatoblastoma;
RX PubMed=15221005; DOI=10.1038/sj.onc.1207782;
RA Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S.,
RA Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S.,
RA Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.;
RT "Expression profiling and differential screening between hepatoblastomas
RT and the corresponding normal livers: identification of high expression of
RT the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.";
RL Oncogene 23:5901-5911(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q7Z5P4; O95870: ABHD16A; NbExp=3; IntAct=EBI-18053395, EBI-348517;
CC Q7Z5P4; Q9UHX3: ADGRE2; NbExp=3; IntAct=EBI-18053395, EBI-11277970;
CC Q7Z5P4; Q9NRZ7: AGPAT3; NbExp=3; IntAct=EBI-18053395, EBI-2803601;
CC Q7Z5P4; Q9NRZ5: AGPAT4; NbExp=3; IntAct=EBI-18053395, EBI-1754287;
CC Q7Z5P4; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-18053395, EBI-11522760;
CC Q7Z5P4; Q9NVV5-2: AIG1; NbExp=3; IntAct=EBI-18053395, EBI-11957045;
CC Q7Z5P4; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-18053395, EBI-12109402;
CC Q7Z5P4; Q16853: AOC3; NbExp=3; IntAct=EBI-18053395, EBI-3921628;
CC Q7Z5P4; P02652: APOA2; NbExp=3; IntAct=EBI-18053395, EBI-1171525;
CC Q7Z5P4; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-18053395, EBI-714543;
CC Q7Z5P4; P27449: ATP6V0C; NbExp=3; IntAct=EBI-18053395, EBI-721179;
CC Q7Z5P4; Q96PG8: BBC3; NbExp=3; IntAct=EBI-18053395, EBI-17289784;
CC Q7Z5P4; Q6PL45-2: BRICD5; NbExp=3; IntAct=EBI-18053395, EBI-12244618;
CC Q7Z5P4; Q06432: CACNG1; NbExp=3; IntAct=EBI-18053395, EBI-9686780;
CC Q7Z5P4; Q5R3K3: CALHM6; NbExp=3; IntAct=EBI-18053395, EBI-19051471;
CC Q7Z5P4; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-18053395, EBI-9083477;
CC Q7Z5P4; O14735: CDIPT; NbExp=3; IntAct=EBI-18053395, EBI-358858;
CC Q7Z5P4; P78369: CLDN10; NbExp=3; IntAct=EBI-18053395, EBI-13372810;
CC Q7Z5P4; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-18053395, EBI-12256978;
CC Q7Z5P4; O14493: CLDN4; NbExp=3; IntAct=EBI-18053395, EBI-9316372;
CC Q7Z5P4; Q8NHS1: CLDND2; NbExp=3; IntAct=EBI-18053395, EBI-11959453;
CC Q7Z5P4; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-18053395, EBI-11522780;
CC Q7Z5P4; Q96FZ5: CMTM7; NbExp=3; IntAct=EBI-18053395, EBI-2807956;
CC Q7Z5P4; P00387: CYB5R3; NbExp=3; IntAct=EBI-18053395, EBI-1046040;
CC Q7Z5P4; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-18053395, EBI-2680384;
CC Q7Z5P4; P78329: CYP4F2; NbExp=3; IntAct=EBI-18053395, EBI-1752413;
CC Q7Z5P4; Q9NR28: DIABLO; NbExp=3; IntAct=EBI-18053395, EBI-517508;
CC Q7Z5P4; Q15125: EBP; NbExp=3; IntAct=EBI-18053395, EBI-3915253;
CC Q7Z5P4; Q5VYK3: ECPAS; NbExp=3; IntAct=EBI-18053395, EBI-521451;
CC Q7Z5P4; Q969F0: FATE1; NbExp=3; IntAct=EBI-18053395, EBI-743099;
CC Q7Z5P4; Q96IV6: FAXDC2; NbExp=3; IntAct=EBI-18053395, EBI-12142299;
CC Q7Z5P4; Q9UGM5: FETUB; NbExp=3; IntAct=EBI-18053395, EBI-13049494;
CC Q7Z5P4; P29033: GJB2; NbExp=3; IntAct=EBI-18053395, EBI-3905204;
CC Q7Z5P4; Q8NBJ4: GOLM1; NbExp=3; IntAct=EBI-18053395, EBI-712073;
CC Q7Z5P4; O14653: GOSR2; NbExp=3; IntAct=EBI-18053395, EBI-4401517;
CC Q7Z5P4; P06028: GYPB; NbExp=3; IntAct=EBI-18053395, EBI-10194756;
CC Q7Z5P4; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-18053395, EBI-3918847;
CC Q7Z5P4; P24593: IGFBP5; NbExp=3; IntAct=EBI-18053395, EBI-720480;
CC Q7Z5P4; Q9Y5U4: INSIG2; NbExp=3; IntAct=EBI-18053395, EBI-8503746;
CC Q7Z5P4; P11215: ITGAM; NbExp=3; IntAct=EBI-18053395, EBI-2568251;
CC Q7Z5P4; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-18053395, EBI-10266796;
CC Q7Z5P4; Q7L5N7: LPCAT2; NbExp=3; IntAct=EBI-18053395, EBI-4280011;
CC Q7Z5P4; O95237: LRAT; NbExp=3; IntAct=EBI-18053395, EBI-13291307;
CC Q7Z5P4; Q9NX47: MARCHF5; NbExp=3; IntAct=EBI-18053395, EBI-2341610;
CC Q7Z5P4; Q6N075: MFSD5; NbExp=3; IntAct=EBI-18053395, EBI-3920969;
CC Q7Z5P4; A0A0C4DFN3: MGLL; NbExp=3; IntAct=EBI-18053395, EBI-12866138;
CC Q7Z5P4; Q96C03-3: MIEF2; NbExp=3; IntAct=EBI-18053395, EBI-11988931;
CC Q7Z5P4; P50281: MMP14; NbExp=3; IntAct=EBI-18053395, EBI-992788;
CC Q7Z5P4; O75425: MOSPD3; NbExp=3; IntAct=EBI-18053395, EBI-12179105;
CC Q7Z5P4; P11836: MS4A1; NbExp=3; IntAct=EBI-18053395, EBI-2808234;
CC Q7Z5P4; Q9H115: NAPB; NbExp=3; IntAct=EBI-18053395, EBI-3921185;
CC Q7Z5P4; Q9UHE5: NAT8; NbExp=3; IntAct=EBI-18053395, EBI-2863634;
CC Q7Z5P4; Q8IXM6: NRM; NbExp=3; IntAct=EBI-18053395, EBI-10262547;
CC Q7Z5P4; Q8N138: ORMDL3; NbExp=3; IntAct=EBI-18053395, EBI-721750;
CC Q7Z5P4; Q96AL5: PBX3; NbExp=3; IntAct=EBI-18053395, EBI-741171;
CC Q7Z5P4; O60664: PLIN3; NbExp=3; IntAct=EBI-18053395, EBI-725795;
CC Q7Z5P4; P26678: PLN; NbExp=3; IntAct=EBI-18053395, EBI-692836;
CC Q7Z5P4; Q04941: PLP2; NbExp=3; IntAct=EBI-18053395, EBI-608347;
CC Q7Z5P4; P54315: PNLIPRP1; NbExp=3; IntAct=EBI-18053395, EBI-8652812;
CC Q7Z5P4; P43378: PTPN9; NbExp=3; IntAct=EBI-18053395, EBI-742898;
CC Q7Z5P4; Q9UI14: RABAC1; NbExp=3; IntAct=EBI-18053395, EBI-712367;
CC Q7Z5P4; Q96HR9-2: REEP6; NbExp=3; IntAct=EBI-18053395, EBI-14065960;
CC Q7Z5P4; Q9NS64: RPRM; NbExp=3; IntAct=EBI-18053395, EBI-1052363;
CC Q7Z5P4; Q96GQ5: RUSF1; NbExp=3; IntAct=EBI-18053395, EBI-8636004;
CC Q7Z5P4; Q9NTJ5: SACM1L; NbExp=3; IntAct=EBI-18053395, EBI-3917235;
CC Q7Z5P4; Q8TAC9: SCAMP5; NbExp=3; IntAct=EBI-18053395, EBI-2695784;
CC Q7Z5P4; Q14162: SCARF1; NbExp=3; IntAct=EBI-18053395, EBI-12056025;
CC Q7Z5P4; O00767: SCD; NbExp=3; IntAct=EBI-18053395, EBI-2684237;
CC Q7Z5P4; O75396: SEC22B; NbExp=3; IntAct=EBI-18053395, EBI-1058865;
CC Q7Z5P4; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-18053395, EBI-10329948;
CC Q7Z5P4; O95562: SFT2D2; NbExp=3; IntAct=EBI-18053395, EBI-4402330;
CC Q7Z5P4; Q9H9B4: SFXN1; NbExp=3; IntAct=EBI-18053395, EBI-355861;
CC Q7Z5P4; Q96NB2: SFXN2; NbExp=3; IntAct=EBI-18053395, EBI-6381136;
CC Q7Z5P4; A0A1P0AYU5: SFXN3; NbExp=3; IntAct=EBI-18053395, EBI-14193895;
CC Q7Z5P4; Q96AG3: SLC25A46; NbExp=3; IntAct=EBI-18053395, EBI-10281975;
CC Q7Z5P4; Q99726: SLC30A3; NbExp=3; IntAct=EBI-18053395, EBI-10294651;
CC Q7Z5P4; Q969S0: SLC35B4; NbExp=3; IntAct=EBI-18053395, EBI-10281213;
CC Q7Z5P4; Q6ICL7: SLC35E4; NbExp=3; IntAct=EBI-18053395, EBI-12867720;
CC Q7Z5P4; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-18053395, EBI-12188413;
CC Q7Z5P4; Q6UX34: SNORC; NbExp=3; IntAct=EBI-18053395, EBI-11957067;
CC Q7Z5P4; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-18053395, EBI-742688;
CC Q7Z5P4; Q96JF0-2: ST6GAL2; NbExp=3; IntAct=EBI-18053395, EBI-12908338;
CC Q7Z5P4; P0DN84: STRIT1; NbExp=3; IntAct=EBI-18053395, EBI-12200293;
CC Q7Z5P4; Q13190: STX5; NbExp=3; IntAct=EBI-18053395, EBI-714206;
CC Q7Z5P4; O15400: STX7; NbExp=3; IntAct=EBI-18053395, EBI-3221827;
CC Q7Z5P4; Q969Z0: TBRG4; NbExp=3; IntAct=EBI-18053395, EBI-702328;
CC Q7Z5P4; P02787: TF; NbExp=3; IntAct=EBI-18053395, EBI-714319;
CC Q7Z5P4; Q9UPZ6: THSD7A; NbExp=3; IntAct=EBI-18053395, EBI-310962;
CC Q7Z5P4; O14925: TIMM23; NbExp=3; IntAct=EBI-18053395, EBI-1047996;
CC Q7Z5P4; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-18053395, EBI-6268651;
CC Q7Z5P4; Q9NV29: TMEM100; NbExp=3; IntAct=EBI-18053395, EBI-8644968;
CC Q7Z5P4; Q9BXJ8: TMEM120A; NbExp=3; IntAct=EBI-18053395, EBI-727322;
CC Q7Z5P4; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-18053395, EBI-2844246;
CC Q7Z5P4; Q9P0S9: TMEM14C; NbExp=3; IntAct=EBI-18053395, EBI-2339195;
CC Q7Z5P4; Q9NRX6: TMEM167B; NbExp=3; IntAct=EBI-18053395, EBI-17684533;
CC Q7Z5P4; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-18053395, EBI-741829;
CC Q7Z5P4; Q969S6: TMEM203; NbExp=3; IntAct=EBI-18053395, EBI-12274070;
CC Q7Z5P4; Q9H0R3: TMEM222; NbExp=3; IntAct=EBI-18053395, EBI-347385;
CC Q7Z5P4; Q8NBD8: TMEM229B; NbExp=3; IntAct=EBI-18053395, EBI-12195227;
CC Q7Z5P4; Q9BU79: TMEM243; NbExp=3; IntAct=EBI-18053395, EBI-12887458;
CC Q7Z5P4; Q8WV15: TMEM255B; NbExp=3; IntAct=EBI-18053395, EBI-2870087;
CC Q7Z5P4; Q69YG0: TMEM42; NbExp=3; IntAct=EBI-18053395, EBI-12038591;
CC Q7Z5P4; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-18053395, EBI-2852148;
CC Q7Z5P4; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-18053395, EBI-2548832;
CC Q7Z5P4; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-18053395, EBI-12111910;
CC Q7Z5P4; Q9Y320: TMX2; NbExp=3; IntAct=EBI-18053395, EBI-6447886;
CC Q7Z5P4; Q6ZUI0: TPRG1; NbExp=3; IntAct=EBI-18053395, EBI-17249488;
CC Q7Z5P4; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-18053395, EBI-16746122;
CC Q7Z5P4; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-18053395, EBI-10243654;
CC Q7Z5P4; O00124: UBXN8; NbExp=3; IntAct=EBI-18053395, EBI-1993850;
CC Q7Z5P4; Q53HI1: UNC50; NbExp=3; IntAct=EBI-18053395, EBI-7601760;
CC Q7Z5P4; P63027: VAMP2; NbExp=3; IntAct=EBI-18053395, EBI-520113;
CC Q7Z5P4; Q9P0L0: VAPA; NbExp=3; IntAct=EBI-18053395, EBI-1059156;
CC Q7Z5P4; O95292: VAPB; NbExp=3; IntAct=EBI-18053395, EBI-1188298;
CC Q7Z5P4; Q9BWQ6: YIPF2; NbExp=3; IntAct=EBI-18053395, EBI-751204;
CC Q7Z5P4; Q9BSR8: YIPF4; NbExp=3; IntAct=EBI-18053395, EBI-751253;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000250|UniProtKB:Q8VCR2}. Lipid droplet
CC {ECO:0000250|UniProtKB:Q8VCR2}. Note=Redistributed from the endoplasmic
CC reticulum to lipids droplets in the cell upon induction of lipids
CC droplet formation. {ECO:0000250|UniProtKB:Q8VCR2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=2;
CC IsoId=Q7Z5P4-1; Sequence=Displayed;
CC Name=1;
CC IsoId=Q7Z5P4-2; Sequence=VSP_015860;
CC -!- TISSUE SPECIFICITY: Highly expressed in the liver. Also detected in
CC ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and
CC testis. {ECO:0000269|PubMed:17311113}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; AY186249; AAO72313.1; -; mRNA.
DR EMBL; AY186250; AAO72314.1; -; mRNA.
DR EMBL; AY268355; AAP42289.1; -; mRNA.
DR EMBL; AY358575; AAQ88938.1; -; mRNA.
DR EMBL; AB073347; BAD38632.1; -; mRNA.
DR EMBL; AK292784; BAF85473.1; -; mRNA.
DR EMBL; CH471057; EAX05986.1; -; Genomic_DNA.
DR EMBL; BC112303; AAI12304.1; -; mRNA.
DR EMBL; BC112305; AAI12306.1; -; mRNA.
DR CCDS; CCDS3618.1; -. [Q7Z5P4-1]
DR CCDS; CCDS47097.1; -. [Q7Z5P4-2]
DR RefSeq; NP_001129702.1; NM_001136230.2. [Q7Z5P4-2]
DR RefSeq; NP_835236.2; NM_178135.4. [Q7Z5P4-1]
DR AlphaFoldDB; Q7Z5P4; -.
DR SMR; Q7Z5P4; -.
DR BioGRID; 131346; 130.
DR IntAct; Q7Z5P4; 117.
DR STRING; 9606.ENSP00000333300; -.
DR GlyGen; Q7Z5P4; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q7Z5P4; -.
DR PhosphoSitePlus; Q7Z5P4; -.
DR BioMuta; HSD17B13; -.
DR DMDM; 74750138; -.
DR jPOST; Q7Z5P4; -.
DR MassIVE; Q7Z5P4; -.
DR MaxQB; Q7Z5P4; -.
DR PaxDb; Q7Z5P4; -.
DR PeptideAtlas; Q7Z5P4; -.
DR PRIDE; Q7Z5P4; -.
DR ProteomicsDB; 69338; -. [Q7Z5P4-1]
DR ProteomicsDB; 69339; -. [Q7Z5P4-2]
DR Antibodypedia; 25413; 164 antibodies from 24 providers.
DR DNASU; 345275; -.
DR Ensembl; ENST00000302219.10; ENSP00000305438.6; ENSG00000170509.12. [Q7Z5P4-2]
DR Ensembl; ENST00000328546.5; ENSP00000333300.4; ENSG00000170509.12. [Q7Z5P4-1]
DR GeneID; 345275; -.
DR KEGG; hsa:345275; -.
DR MANE-Select; ENST00000328546.5; ENSP00000333300.4; NM_178135.5; NP_835236.2.
DR UCSC; uc003hqo.3; human. [Q7Z5P4-1]
DR CTD; 345275; -.
DR DisGeNET; 345275; -.
DR GeneCards; HSD17B13; -.
DR HGNC; HGNC:18685; HSD17B13.
DR HPA; ENSG00000170509; Tissue enriched (liver).
DR MIM; 612127; gene.
DR neXtProt; NX_Q7Z5P4; -.
DR OpenTargets; ENSG00000170509; -.
DR PharmGKB; PA38634; -.
DR VEuPathDB; HostDB:ENSG00000170509; -.
DR eggNOG; KOG1201; Eukaryota.
DR GeneTree; ENSGT00940000161743; -.
DR HOGENOM; CLU_010194_2_5_1; -.
DR InParanoid; Q7Z5P4; -.
DR OMA; GRWTAYE; -.
DR OrthoDB; 1373099at2759; -.
DR PhylomeDB; Q7Z5P4; -.
DR TreeFam; TF312837; -.
DR PathwayCommons; Q7Z5P4; -.
DR Reactome; R-HSA-8964572; Lipid particle organization.
DR SignaLink; Q7Z5P4; -.
DR BioGRID-ORCS; 345275; 10 hits in 1068 CRISPR screens.
DR ChiTaRS; HSD17B13; human.
DR GenomeRNAi; 345275; -.
DR Pharos; Q7Z5P4; Tbio.
DR PRO; PR:Q7Z5P4; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q7Z5P4; protein.
DR Bgee; ENSG00000170509; Expressed in liver and 90 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005811; C:lipid droplet; IDA:MGI.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0016229; F:steroid dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0046889; P:positive regulation of lipid biosynthetic process; IDA:MGI.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Endoplasmic reticulum; Lipid droplet; NAD;
KW Oxidoreductase; Phosphoprotein; Reference proteome; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..300
FT /note="17-beta-hydroxysteroid dehydrogenase 13"
FT /id="PRO_0000042583"
FT ACT_SITE 185
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 40..67
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT BINDING 172
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 189
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT MOD_RES 33
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5M875"
FT VAR_SEQ 71..106
FT /note="Missing (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_015860"
FT CONFLICT 260
FT /note="P -> S (in Ref. 1; AAO72313)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 300 AA; 33655 MW; 5B85778554265DFE CRC64;
MNIILEILLL LITIIYSYLE SLVKFFIPQR RKSVAGEIVL ITGAGHGIGR QTTYEFAKRQ
SILVLWDINK RGVEETAAEC RKLGVTAHAY VVDCSNREEI YRSLNQVKKE VGDVTIVVNN
AGTVYPADLL STKDEEITKT FEVNILGHFW ITKALLPSMM ERNHGHIVTV ASVCGHEGIP
YLIPYCSSKF AAVGFHRGLT SELQALGKTG IKTSCLCPVF VNTGFTKNPS TRLWPVLETD
EVVRSLIDGI LTNKKMIFVP SYINIFLRLQ KFLPERASAI LNRMQNIQFE AVVGHKIKMK
