ID   ADAD1_XENLA             Reviewed;         586 AA.
AC   Q32NG0;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Adenosine deaminase domain-containing protein 1;
GN   Name=adad1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be required for male fertility and normal male germ cell
CC       differentiation (By similarity). May play a role in spermatogenesis.
CC       Binds to RNA but not to DNA (By similarity).
CC       {ECO:0000250|UniProtKB:Q5SUE7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5SUE7}.
CC   -!- SIMILARITY: Belongs to the ADAD family. {ECO:0000305}.
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DR   EMBL; BC108644; AAI08645.1; -; mRNA.
DR   RefSeq; NP_001089899.1; NM_001096430.1.
DR   AlphaFoldDB; Q32NG0; -.
DR   SMR; Q32NG0; -.
DR   DNASU; 734966; -.
DR   GeneID; 734966; -.
DR   KEGG; xla:734966; -.
DR   CTD; 734966; -.
DR   Xenbase; XB-GENE-866245; adad1.L.
DR   OrthoDB; 947117at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 734966; Expressed in testis and 8 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   GO; GO:0007286; P:spermatid development; ISS:UniProtKB.
DR   CDD; cd19905; DSRM_ADAD1; 1.
DR   InterPro; IPR002466; A_deamin.
DR   InterPro; IPR044455; ADAD1_DSRM.
DR   InterPro; IPR014720; dsRBD_dom.
DR   Pfam; PF02137; A_deamin; 1.
DR   Pfam; PF00035; dsrm; 1.
DR   SMART; SM00552; ADEAMc; 1.
DR   SMART; SM00358; DSRM; 1.
DR   PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Nucleus; Reference proteome;
KW   RNA-binding; Spermatogenesis.
FT   CHAIN           1..586
FT                   /note="Adenosine deaminase domain-containing protein 1"
FT                   /id="PRO_0000309523"
FT   DOMAIN          98..166
FT                   /note="DRBM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   DOMAIN          258..584
FT                   /note="A to I editase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00240"
FT   REGION          183..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   586 AA;  64796 MW;  83039F2EBF969688 CRC64;
     MASNRNWSQH SSVPSFAQML KKNLPDPGTS PAVNQTSTLS TCCLYNQPDC GTARVTRITG
     NFPEPFLSKM IVPPSLSSLT PRKVTKEFMV KYRRGDLNPI SALYQFAQMQ RMEIELKETV
     TTGNVFGAYF AFCAVVDGLE YKTGMGQNKK EAKANAAKLA LDELLLHEDP ALIDSENQSL
     NVIENPPPLP MNPRGTTETS TISRTRTDKR TFIHEKISSI IKETFTNLVS KYPEYENCGS
     SLAAFVIEKG GQHWEVVAIG TGEFNYGQSL QSDGRVLHDS HAMVVARRSL LRYFYRQLLL
     LYSGNNGMMD KSIFCTEPAT NLLALKPNLN IFLYMNQLPK GAAQTNPQLC LSPHSLSAHE
     ANDKLSLHVS VEGKNIPASY YSGEIVHNLY SMSSTDKLTR WEVLGVQGAL LSIFIQPVYI
     NSIIIGNAAC SDTRGLEIAV KQRIDDALTS RLPMFYLVNR PYMSIVSSTH LTNNDTANKT
     LSLNWSQGDA CVEVVDAAIG RTVEGSPFKS GSCLASRLCK AAMLCRFNLV VKESKRNAIP
     SGLSYHEAKR LAGPYQEAKC LLNSYFKQQG FGSWIAKPPI IGEFTM