ID   DHB1_PANTR              Reviewed;         328 AA.
AC   Q1WNP0;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Estradiol 17-beta-dehydrogenase 1;
DE            EC=1.1.1.62;
DE   AltName: Full=17-beta-hydroxysteroid dehydrogenase type 1;
DE            Short=17-beta-HSD 1;
GN   Name=HSD17B1;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16337734; DOI=10.1016/j.mce.2005.10.014;
RA   Keller B., Ohnesorg T., Mindnich R., Gloeckner C.J., Breitling R.,
RA   Scharfe M., Moeller G., Bloecker H., Adamski J.;
RT   "Interspecies comparison of gene structure and computational analysis of
RT   gene regulation of 17beta-hydroxysteroid dehydrogenase type 1.";
RL   Mol. Cell. Endocrinol. 248:168-171(2006).
CC   -!- FUNCTION: Favors the reduction of estrogens and androgens. Also has 20-
CC       alpha-HSD activity. Uses preferentially NADH.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH;
CC         Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469,
CC         ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=17beta-estradiol + NADP(+) = estrone + H(+) + NADPH;
CC         Xref=Rhea:RHEA:24616, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469,
CC         ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.62;
CC   -!- PATHWAY: Steroid biosynthesis; estrogen biosynthesis.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; DQ023266; AAZ22356.1; -; Genomic_DNA.
DR   RefSeq; XP_016802348.1; XM_016946859.1.
DR   AlphaFoldDB; Q1WNP0; -.
DR   SMR; Q1WNP0; -.
DR   STRING; 9598.ENSPTRP00000015678; -.
DR   PaxDb; Q1WNP0; -.
DR   Ensembl; ENSPTRT00000110818; ENSPTRP00000062753; ENSPTRG00000052042.
DR   VGNC; VGNC:12310; HSD17B1.
DR   eggNOG; KOG1205; Eukaryota.
DR   GeneTree; ENSGT00940000160415; -.
DR   InParanoid; Q1WNP0; -.
DR   UniPathway; UPA00769; -.
DR   Proteomes; UP000002277; Unplaced.
DR   Bgee; ENSPTRG00000052042; Expressed in superior frontal gyrus and 20 other tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0044594; F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity; IEA:RHEA.
DR   GO; GO:0004303; F:estradiol 17-beta-dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0006703; P:estrogen biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR011348; 17beta_DH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PIRSF; PIRSF000095; 17beta-HSD; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lipid biosynthesis; Lipid metabolism; NADP; Oxidoreductase;
KW   Reference proteome; Steroid biosynthesis.
FT   CHAIN           1..328
FT                   /note="Estradiol 17-beta-dehydrogenase 1"
FT                   /id="PRO_0000251152"
FT   REGION          290..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        156
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         10..38
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         66
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         143
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         160
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   328 AA;  34889 MW;  D390680343130598 CRC64;
     MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA RALACPPGSL
     ETLQLDVRDS KSVAAARERV TEGRVDVLVC NAGLGLLGPL EALGEDAVAS VLDVNVVGTV
     RVLQAFLPDM KRRGSGRVLV TGSVGGLMGL PFNDVYCASK FALEGLCESL AVLLLPFGVH
     LSLIECGPVH TAFMEKVLGS PEEVLDRTDI HTFHRFYQYL AHSKQVFREA AQNPEEVAEV
     FLTALRAPKP TLRYFTTERF LPLLRMRLDD PSGSNYVTAM HREVFGDVPA KAEAGAEAGG
     GAGPGAEDEA GPSAVGDPEL GDPPAAPQ