ID   ADAD2_MACFA             Reviewed;         580 AA.
AC   Q95JV3; Q95JT2;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Adenosine deaminase domain-containing protein 2 {ECO:0000250|UniProtKB:Q8NCV1};
GN   Name=ADAD2 {ECO:0000250|UniProtKB:Q8NCV1}; ORFNames=QtsA-11888, QtsA-13619;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RA   Hashimoto K., Osada N., Hida M., Kusuda J., Tanuma R., Hirai M., Terao K.,
RA   Sugano S.;
RT   "Isolation of novel full-length cDNA clones from macaque testis cDNA
RT   libraries.";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
CC   -!- FUNCTION: Required for male fertility and normal male germ cell
CC       differentiation. {ECO:0000250|UniProtKB:Q9D5P4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D5P4}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9D5P4}. Note=Diffusely cytoplasmic early in
CC       pachytene spermatocytes and coalesces into several perinuclear granules
CC       by late pachynema. {ECO:0000250|UniProtKB:Q9D5P4}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q95JV3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q95JV3-2; Sequence=VSP_029232;
CC   -!- SIMILARITY: Belongs to the ADAD family. {ECO:0000305}.
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DR   EMBL; AB070075; BAB63020.1; -; mRNA.
DR   EMBL; AB070097; BAB63042.1; -; mRNA.
DR   RefSeq; NP_001271587.1; NM_001284658.1.
DR   AlphaFoldDB; Q95JV3; -.
DR   SMR; Q95JV3; -.
DR   STRING; 9541.XP_005592724.1; -.
DR   GeneID; 102129569; -.
DR   CTD; 161931; -.
DR   VEuPathDB; HostDB:ENSMFAG00000044274; -.
DR   eggNOG; KOG2777; Eukaryota.
DR   Proteomes; UP000233100; Chromosome 20.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   GO; GO:0007286; P:spermatid development; ISS:UniProtKB.
DR   CDD; cd19906; DSRM_ADAD2; 1.
DR   InterPro; IPR002466; A_deamin.
DR   InterPro; IPR044454; ADAD2_DSRM.
DR   InterPro; IPR014720; dsRBD_dom.
DR   Pfam; PF02137; A_deamin; 1.
DR   Pfam; PF00035; dsrm; 1.
DR   SMART; SM00552; ADEAMc; 1.
DR   PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Differentiation; Nucleus;
KW   Reference proteome; RNA-binding; Spermatogenesis.
FT   CHAIN           1..580
FT                   /note="Adenosine deaminase domain-containing protein 2"
FT                   /id="PRO_0000309525"
FT   DOMAIN          112..178
FT                   /note="DRBM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   DOMAIN          258..579
FT                   /note="A to I editase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00240"
FT   REGION          1..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         37..54
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12498619"
FT                   /id="VSP_029232"
FT   CONFLICT        160
FT                   /note="S -> G (in Ref. 2; BAB63042)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        491
FT                   /note="P -> S (in Ref. 1; BAB63020)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   580 AA;  61242 MW;  BC1ADB1D59B938CD CRC64;
     MASASQGADD GSRRKPRLAA SLQISPEPRP WRPLPPQAQG AWEPAPAMDH AEGGQPQVSV
     LRDSGPGAGA GVGELGAAQA WENLGEQMGR TPRVPVPPAG LSLPLKDPPA SQAVSLLTEY
     AASLGIILLF REDQQPGPCF PFSVSAELDG VVCPAGTANS KTEAKQQAAL SALCYIRSQL
     ESPESPQTSS RPPPPPLSVD SILTHGQRCA ALVSAGFDLL LDERSPYWAC KGTVAGVILE
     REIPGARGHV KEIYKLVALG TGSSCCAGWL EFSGQQLHDC HGLVIARRAL LRFLFRQLLL
     ATQGGAKGKE QSVLAPQPGP GPPFTLKPRV FLHLYISNTP KGAARDIYLP PTSEGGLPHS
     PPMRLQAHVL GQLKPVCYVA PSLCDTHVGC LSASDKLARW AVLGLGGALL AHLVSPLYST
     SLILADSCHD PPTLSRAIHT RPCLDSVLGP CLPPPYVRTA LHLFSGPPVA PSEPTPDTCH
     GLSLNWSLGD PGIEVVDVAT GRVKANAALG PPSRLCKASF LRAFHQVARA VGKPYLLALK
     TYEAAKAGPY QEARRQLSLL LDQQGLGAWP SKPLVGKFRN