ID   DHBK_SOLLC              Reviewed;         594 AA.
AC   O04059;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Putative 3,4-dihydroxy-2-butanone kinase;
DE            EC=2.7.1.-;
GN   Name=DHBK;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. UC82B;
RA   Herz S., Eberhardt S., Bacher A.;
RT   "L. esculentum mRNA for 3,4 -dihydroxy-2-butanone kinase.";
RL   Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the dihydroxyacetone kinase (DAK) family.
CC       {ECO:0000305}.
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DR   EMBL; Y12090; CAA72805.1; -; mRNA.
DR   PIR; T06369; T06369.
DR   RefSeq; NP_001234326.2; NM_001247397.2.
DR   AlphaFoldDB; O04059; -.
DR   SMR; O04059; -.
DR   STRING; 4081.Solyc06g072380.2.1; -.
DR   PaxDb; O04059; -.
DR   GeneID; 544126; -.
DR   KEGG; sly:544126; -.
DR   eggNOG; KOG2426; Eukaryota.
DR   InParanoid; O04059; -.
DR   OrthoDB; 472175at2759; -.
DR   Proteomes; UP000004994; Unplaced.
DR   ExpressionAtlas; O04059; baseline.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004371; F:glycerone kinase activity; IBA:GO_Central.
DR   GO; GO:0019563; P:glycerol catabolic process; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.340; -; 1.
DR   InterPro; IPR012734; DhaK_ATP.
DR   InterPro; IPR004006; DhaK_dom.
DR   InterPro; IPR004007; DhaL_dom.
DR   InterPro; IPR036117; DhaL_dom_sf.
DR   Pfam; PF02733; Dak1; 1.
DR   Pfam; PF02734; Dak2; 1.
DR   SMART; SM01120; Dak2; 1.
DR   SUPFAM; SSF101473; SSF101473; 1.
DR   TIGRFAMs; TIGR02361; dak_ATP; 1.
DR   PROSITE; PS51481; DHAK; 1.
DR   PROSITE; PS51480; DHAL; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN           1..594
FT                   /note="Putative 3,4-dihydroxy-2-butanone kinase"
FT                   /id="PRO_0000121531"
FT   DOMAIN          11..341
FT                   /note="DhaK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00814"
FT   DOMAIN          381..585
FT                   /note="DhaL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00813"
FT   REGION          339..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        226
FT                   /note="Tele-hemiaminal-histidine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00814"
FT   BINDING         62..65
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         113
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         118
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         410..413
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         455..456
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         499
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         507..508
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         570..572
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   594 AA;  61801 MW;  BA19CBEA81BE24AB CRC64;
     MDFQSKKLIN DPNDVVTEFI EGLIENYPGL QYLDGFPEVK VVLRADVSGA KYDKVAIISG
     GGSGHEPAHA GFVGEGMLTA AICGDVFASP NVDSILAGIR AVTGPMGCLL IVKNYTGDRL
     NFGLAAEQAK SEGYKVEMVI VGDDCALPPP RGIAGRRGLA GTLLVHKVAG AAAACGLPLA
     DVAAEAKRAS EMVGTMGVAL SVCTSPGQVT SDRLGPGKME LGLGIHGEPG AAVADLQPVD
     VVVSHVLKEI LSPETNYVPI TRGSRVVLLI NGLGATPLME LMIIAGKAVP ELQLEHGLAV
     DRVYTGSFMT SLDMAGFSIS VMKADQAILD RLDAPTKAPN WPVGAEGNRP PAKIPVPLPP
     SHSIKIEKTL SRPEKLSPQG HILETAIEAA ATEVVNLRDN LNEWDNKVGD GDCGSTMFRG
     AVAILEDMKK YYPLNDPAET VNEIGASIGR VMGGTSGILY SIFCKAAYAK LKENAESVVT
     AIHWADALEA AIAAVSKYGG ASAGYRTLLD ALIPALSALK ERLNAGDDPA DAFIISAEAA
     SAGAESTKHM QAQAGRSTYV PGDILASVPD PGAMAAAAWY RAAALAVKEK YNTA