ID   DHC4_ALTCI              Reviewed;         764 AA.
AC   A0A0N6WJC7;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2016, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Dehydrocurvularin biosynthesis regulator {ECO:0000303|PubMed:26493380};
DE   AltName: Full=Dehydrocurvularin biosynthesis protein 4 {ECO:0000303|PubMed:26493380};
GN   Name=Dhc4 {ECO:0000303|PubMed:26493380};
OS   Alternaria cinerariae.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Alternaria;
OC   Alternaria sect. Sonchi.
OX   NCBI_TaxID=216837;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   STRAIN=ATCC 11784;
RX   PubMed=26493380; DOI=10.1002/cbic.201500428;
RA   Cochrane R.V., Gao Z., Lambkin G.R., Xu W., Winter J.M., Marcus S.L.,
RA   Tang Y., Vederas J.C.;
RT   "Comparison of 10,11-dehydrocurvularin polyketide synthases from Alternaria
RT   cinerariae and Aspergillus terreus highlights key structural motifs.";
RL   ChemBioChem 16:2479-2483(2015).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ATCC 11784;
RA   Cajimat M.N.B., Milazzo M.L., Fulhorst C.F.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor involved in regulation of the
CC       dehydrocurvularin biosynthesis gene cluster (PubMed:26493380).
CC       {ECO:0000305|PubMed:26493380}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; KT271473; AKQ49202.1; -; mRNA.
DR   AlphaFoldDB; A0A0N6WJC7; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..764
FT                   /note="Dehydrocurvularin biosynthesis regulator"
FT                   /id="PRO_0000438393"
FT   DNA_BIND        28..59
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          73..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          112..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          633..672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..136
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   764 AA;  85533 MW;  E9437C56661D72AD CRC64;
     MSSPRAAPSH DTFPNAKRRK VRKGTHSCWE CKRRKMKCIF DPRITSTSCN GCRQRGSPCI
     SQEFVQDDSH VAHGANDSAS LDASTPIATP SDDARRADHD ILTPVSVDSE PYRYLPSSKS
     SDKRFTTRSS NDASTCPMKH EKLSKYLHEA LPSREDTERI CKASRHSSIL AHELLTVPYD
     TLYRNGLKTP DSLLAIPEPH VHPVLIAKHM LQLATFLQHL HPDLDKEIKV LSESPRAIMQ
     RLVDIAIHHI TTNNELLGSV ESLECVMIES LYQANIGNLR KSWVAGRRAM SIAQLMGLHR
     SDSLSQYKVL DPKTEYNPQL MWLRIVTLDR HLCLLLGLPQ GCTDRSMASE TCLSNDTQMG
     RLERLHCVLM SRILERNEYS TNAQHAVVTR EIDLELQKAA RGLTSKWWLA PKLNTASADL
     QVHFWDTRRL LAQIFHYNLL IQLHLPYMLR VSSDESKHDY SRMTCVNASR EVLSRYITLR
     NLNRIAYSCR TVDFIALMAA MALLLAHMNC HRAGAVNPLA HQYLSDRAMI EQVQENMHEI
     NKLNSDALSA QSADLLKKLL AIEMEAGDTR VSVSEASNGV VQQDGTTREE DGVVSVQVPY
     FGIIRIGKDT PTKNQASVTA TMHGTAPLHL DRFPTSINTN SDPVHVHSQA DFPSSTQLSS
     SSHPNTPSPA LSLNNIPFHA TCMAALPDSS VVFTRQQHQK QQQEHQEFGG DLATVSDTSF
     PSSLHATWQD NFPELAAGSE DWAFQGVDMA FFESIMRSDT NLGQ