ID   DHDH_BOVIN              Reviewed;         335 AA.
AC   Q148L6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase;
DE            EC=1.3.1.20;
DE   AltName: Full=D-xylose 1-dehydrogenase;
DE   AltName: Full=D-xylose-NADP dehydrogenase;
DE            EC=1.1.1.179;
DE   AltName: Full=Dimeric dihydrodiol dehydrogenase;
GN   Name=DHDH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol +
CC         H(+) + NADPH; Xref=Rhea:RHEA:16729, ChEBI:CHEBI:10702,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:18135, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349; EC=1.3.1.20;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH;
CC         Xref=Rhea:RHEA:22000, ChEBI:CHEBI:15378, ChEBI:CHEBI:15867,
CC         ChEBI:CHEBI:53455, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC         EC=1.1.1.179;
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000305}.
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DR   EMBL; BC118168; AAI18169.1; -; mRNA.
DR   RefSeq; NP_001069937.1; NM_001076469.1.
DR   AlphaFoldDB; Q148L6; -.
DR   SMR; Q148L6; -.
DR   STRING; 9913.ENSBTAP00000040682; -.
DR   PaxDb; Q148L6; -.
DR   PRIDE; Q148L6; -.
DR   Ensembl; ENSBTAT00000043087; ENSBTAP00000040682; ENSBTAG00000013337.
DR   GeneID; 617564; -.
DR   KEGG; bta:617564; -.
DR   CTD; 27294; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013337; -.
DR   VGNC; VGNC:28036; DHDH.
DR   eggNOG; KOG2741; Eukaryota.
DR   GeneTree; ENSGT00390000007946; -.
DR   HOGENOM; CLU_023194_7_2_1; -.
DR   InParanoid; Q148L6; -.
DR   OMA; FINYCQY; -.
DR   OrthoDB; 943656at2759; -.
DR   TreeFam; TF324504; -.
DR   BRENDA; 1.3.1.20; 908.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000013337; Expressed in biceps femoris and 103 other tissues.
DR   GO; GO:0047837; F:D-xylose 1-dehydrogenase (NADP+) activity; IBA:GO_Central.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0047115; F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042843; P:D-xylose catabolic process; IBA:GO_Central.
DR   InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR   InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01408; GFO_IDH_MocA; 1.
DR   Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..335
FT                   /note="Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase"
FT                   /id="PRO_0000315359"
FT   SITE            71
FT                   /note="May play an important role in coenzyme binding"
FT                   /evidence="ECO:0000250"
FT   SITE            79
FT                   /note="May play an important role in coenzyme binding"
FT                   /evidence="ECO:0000250"
FT   SITE            97
FT                   /note="May play an important role in coenzyme binding"
FT                   /evidence="ECO:0000250"
FT   SITE            176
FT                   /note="May play an important role for the adaptation of the
FT                   alcohol substrate into the binding site"
FT                   /evidence="ECO:0000250"
FT   SITE            180
FT                   /note="May play an important role in catalytic activity"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   335 AA;  36583 MW;  3D6B91F2F9220BAA CRC64;
     MALRWGIVSA GLISSDFTTM LRMLPRSEHQ VVAVAARDLS RAKEFAKKHD IPKAYGSYEE
     LAKDPDVEVA YIGTQHPQHK AAVLLCLTAG KAVLCEKPMG VNAAEVREMV AEARSRGLFF
     MEAIWTRFFP AVEALRSVLA QGTLGDLRVV RAEFGKNLTH VHRATDWAQA GGGLLDLGIY
     CLQFISMVFG GQKPEKISAV GRRHETGVDD TVTVILQYPG GVHGSFTCSI SAQLSNTVSV
     SGTKGMAQLL DPCWSPTELV VKGEHKEFPL PPAPGKEFNF TNGMGMSYEA KHVRECLQKG
     LKESPVIPLV ESELLADILE EVRKAIGITF PQDKH