DHDH_HUMAN
ID DHDH_HUMAN Reviewed; 334 AA.
AC Q9UQ10;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase;
DE EC=1.3.1.20;
DE AltName: Full=D-xylose 1-dehydrogenase;
DE AltName: Full=D-xylose-NADP dehydrogenase;
DE EC=1.1.1.179;
DE AltName: Full=Dimeric dihydrodiol dehydrogenase;
DE AltName: Full=Hum2DD;
GN Name=DHDH; Synonyms=2DD;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, AND TISSUE SPECIFICITY.
RC TISSUE=Small intestine;
RX PubMed=10477285; DOI=10.1042/bj3420721;
RA Arimitsu E., Aoki S., Ishikura S., Nakanishi K., Matsuura K., Hara A.;
RT "Cloning and sequencing of the cDNA species for mammalian dimeric
RT dihydrodiol dehydrogenases.";
RL Biochem. J. 342:721-728(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol +
CC H(+) + NADPH; Xref=Rhea:RHEA:16729, ChEBI:CHEBI:10702,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:18135, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349; EC=1.3.1.20;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH;
CC Xref=Rhea:RHEA:22000, ChEBI:CHEBI:15378, ChEBI:CHEBI:15867,
CC ChEBI:CHEBI:53455, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.1.1.179;
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:10477285}.
CC -!- TISSUE SPECIFICITY: Small intestine. {ECO:0000269|PubMed:10477285}.
CC -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000305}.
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DR EMBL; BC032730; AAH32730.1; -; mRNA.
DR EMBL; AB021933; BAA83490.1; -; mRNA.
DR EMBL; CH471177; EAW52414.1; -; Genomic_DNA.
DR CCDS; CCDS12741.1; -.
DR RefSeq; NP_055290.1; NM_014475.3.
DR AlphaFoldDB; Q9UQ10; -.
DR SMR; Q9UQ10; -.
DR BioGRID; 118118; 71.
DR STRING; 9606.ENSP00000221403; -.
DR PhosphoSitePlus; Q9UQ10; -.
DR BioMuta; DHDH; -.
DR DMDM; 74735193; -.
DR MassIVE; Q9UQ10; -.
DR PaxDb; Q9UQ10; -.
DR PeptideAtlas; Q9UQ10; -.
DR PRIDE; Q9UQ10; -.
DR ProteomicsDB; 85489; -.
DR Antibodypedia; 31841; 165 antibodies from 25 providers.
DR DNASU; 27294; -.
DR Ensembl; ENST00000221403.7; ENSP00000221403.2; ENSG00000104808.8.
DR GeneID; 27294; -.
DR KEGG; hsa:27294; -.
DR MANE-Select; ENST00000221403.7; ENSP00000221403.2; NM_014475.4; NP_055290.1.
DR UCSC; uc002ple.1; human.
DR CTD; 27294; -.
DR DisGeNET; 27294; -.
DR GeneCards; DHDH; -.
DR HGNC; HGNC:17887; DHDH.
DR HPA; ENSG00000104808; Group enriched (intestine, kidney).
DR MIM; 606377; gene.
DR neXtProt; NX_Q9UQ10; -.
DR OpenTargets; ENSG00000104808; -.
DR PharmGKB; PA27322; -.
DR VEuPathDB; HostDB:ENSG00000104808; -.
DR eggNOG; KOG2741; Eukaryota.
DR GeneTree; ENSGT00390000007946; -.
DR HOGENOM; CLU_023194_7_2_1; -.
DR InParanoid; Q9UQ10; -.
DR OMA; FINYCQY; -.
DR OrthoDB; 943656at2759; -.
DR PhylomeDB; Q9UQ10; -.
DR TreeFam; TF324504; -.
DR PathwayCommons; Q9UQ10; -.
DR SignaLink; Q9UQ10; -.
DR BioGRID-ORCS; 27294; 14 hits in 1074 CRISPR screens.
DR ChiTaRS; DHDH; human.
DR GenomeRNAi; 27294; -.
DR Pharos; Q9UQ10; Tbio.
DR PRO; PR:Q9UQ10; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9UQ10; protein.
DR Bgee; ENSG00000104808; Expressed in kidney epithelium and 117 other tissues.
DR ExpressionAtlas; Q9UQ10; baseline and differential.
DR Genevisible; Q9UQ10; HS.
DR GO; GO:0047837; F:D-xylose 1-dehydrogenase (NADP+) activity; IBA:GO_Central.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0047115; F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0042843; P:D-xylose catabolic process; IBA:GO_Central.
DR InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..334
FT /note="Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase"
FT /id="PRO_0000315361"
FT SITE 71
FT /note="May play an important role in coenzyme binding"
FT /evidence="ECO:0000250"
FT SITE 79
FT /note="May play an important role in coenzyme binding"
FT /evidence="ECO:0000250"
FT SITE 97
FT /note="May play an important role in coenzyme binding"
FT /evidence="ECO:0000250"
FT SITE 176
FT /note="May play an important role for the adaptation of the
FT alcohol substrate into the binding site"
FT /evidence="ECO:0000250"
FT SITE 180
FT /note="May play an important role in catalytic activity"
FT /evidence="ECO:0000250"
FT VARIANT 2
FT /note="A -> P (in dbSNP:rs10401800)"
FT /id="VAR_038174"
FT VARIANT 66
FT /note="S -> N (in dbSNP:rs2270941)"
FT /id="VAR_038175"
FT VARIANT 200
FT /note="V -> M (in dbSNP:rs35453148)"
FT /id="VAR_038176"
FT VARIANT 247
FT /note="V -> A (in dbSNP:rs11666105)"
FT /id="VAR_038177"
FT VARIANT 282
FT /note="G -> R (in dbSNP:rs3765148)"
FT /id="VAR_038178"
SQ SEQUENCE 334 AA; 36382 MW; 1E2E11DF0B55214B CRC64;
MALRWGIVSV GLISSDFTAV LQTLPRSEHQ VVAVAARDLS RAKEFAQKHD IPKAYGSYEE
LAKDPSVEVA YIGTQHPQHK AAVMLCLAAG KAVLCEKPTG VNAAEVREMV AEARSRALFL
MEAIWTRFFP ASEALRSVLA QGTLGDLRVA RAEFGKNLIH VPRAVDRAQA GGALLDIGIY
CVQFTSMVFG GQKPEKISVV GRRHETGVDD TVTVLLQYPG EVHGSFTCSI TVQLSNTASV
SGTKGMVQLL NPCWCPTELV VKGEHKEFPL PPVPKDCNFD NGAGMSYEAK HVWECLRKGM
KESPVIPLSE SELLADILEE VRKAIGVTFP QDKR
