ID   DHE_HALSA               Reviewed;         416 AA.
AC   Q9HQE1; Q5MBG1;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Glutamate dehydrogenase A2;
DE            EC=1.4.1.-;
GN   Name=gdhA2; OrderedLocusNames=VNG_1204G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [2]
RP   IDENTIFICATION.
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=15780999; DOI=10.1016/j.gene.2005.01.011;
RA   Ingoldsby L.M., Geoghegan K.F., Hayden B.M., Engel P.C.;
RT   "The discovery of four distinct glutamate dehydrogenase genes in a strain
RT   of Halobacterium salinarum.";
RL   Gene 349:237-244(2005).
CC   -!- SUBUNIT: Homohexamer. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Strain NRC-36014 contains 4 distinct glutamate
CC       dehydrogenases while strain NRC-1 contains only 3.
CC       {ECO:0000305|PubMed:15780999}.
CC   -!- SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
CC       {ECO:0000305}.
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DR   EMBL; AE004437; AAG19574.1; -; Genomic_DNA.
DR   PIR; B84276; B84276.
DR   RefSeq; WP_010902870.1; NC_002607.1.
DR   AlphaFoldDB; Q9HQE1; -.
DR   SMR; Q9HQE1; -.
DR   STRING; 64091.VNG_1204G; -.
DR   PaxDb; Q9HQE1; -.
DR   EnsemblBacteria; AAG19574; AAG19574; VNG_1204G.
DR   GeneID; 5952864; -.
DR   GeneID; 62884561; -.
DR   KEGG; hal:VNG_1204G; -.
DR   PATRIC; fig|64091.14.peg.922; -.
DR   HOGENOM; CLU_025763_1_2_2; -.
DR   InParanoid; Q9HQE1; -.
DR   OMA; TNAWWWW; -.
DR   OrthoDB; 40988at2157; -.
DR   PhylomeDB; Q9HQE1; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0004352; F:glutamate dehydrogenase (NAD+) activity; IBA:GO_Central.
DR   GO; GO:0006538; P:glutamate catabolic process; IBA:GO_Central.
DR   CDD; cd01076; NAD_bind_1_Glu_DH; 1.
DR   InterPro; IPR046346; Aminiacid_DH-like_N_sf.
DR   InterPro; IPR006095; Glu/Leu/Phe/Val_DH.
DR   InterPro; IPR033524; Glu/Leu/Phe/Val_DH_AS.
DR   InterPro; IPR006096; Glu/Leu/Phe/Val_DH_C.
DR   InterPro; IPR006097; Glu/Leu/Phe/Val_DH_dimer_dom.
DR   InterPro; IPR014362; Glu_DH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR033922; NAD_bind_Glu_DH.
DR   Pfam; PF00208; ELFV_dehydrog; 1.
DR   Pfam; PF02812; ELFV_dehydrog_N; 1.
DR   PIRSF; PIRSF000185; Glu_DH; 1.
DR   PRINTS; PR00082; GLFDHDRGNASE.
DR   SMART; SM00839; ELFV_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF53223; SSF53223; 1.
DR   PROSITE; PS00074; GLFV_DEHYDROGENASE; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..416
FT                   /note="Glutamate dehydrogenase A2"
FT                   /id="PRO_0000428792"
FT   ACT_SITE        105
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10011"
SQ   SEQUENCE   416 AA;  45332 MW;  11DA56F6C24BEB74 CRC64;
     MTESGPLENM LAQMEQAREY VDIDDGIYER LKSPERTLSV SLPVRMDDGS VEVFDAYRCQ
     FDSARGPYKG GIRYHPTVSE EEVSALAGWM TWKTALVDLP FGGAKGGIVC NPKELSDNEI
     EQLTRRYTEG IRRMIGPETD IPAPDMNTDP RTMAWVMDTY SVYQGYAVPE VVTGKPPEIG
     GTDGRVEATG RGVSIITEET FEYFDTDIQD ADVAIQGFGN VGSVTADLLS ERGANIVAVS
     DVTGAIHDPT GLDIADVQAY ADANGGRLEG YDAEPISNDD LLTLDVDALI PAAIEDVITV
     DVAERLAADV IVEAANGPTT FDAAQVLSDR GVPVVPDILA NAGGVIVSYL EWVQNSQQYS
     WDVEEVNRDL RQRLTGAFDE MLVAYEDRNI PTLRTAAYTI ALERSADAHE FRGLFP