ID   DHI1A_XENLA             Reviewed;         291 AA.
AC   Q6P7J1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Hydroxysteroid 11-beta-dehydrogenase 1-like protein A;
DE            EC=1.1.1.-;
DE   AltName: Full=11-beta-hydroxysteroid dehydrogenase type 3-A;
DE            Short=11-DH3-A;
DE            Short=11-beta-HSD3-A;
DE   Flags: Precursor;
GN   Name=hsd11b1l-a; Synonyms=hsd3-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; BC061652; AAH61652.1; -; mRNA.
DR   RefSeq; NP_001083596.1; NM_001090127.1.
DR   AlphaFoldDB; Q6P7J1; -.
DR   SMR; Q6P7J1; -.
DR   DNASU; 399012; -.
DR   GeneID; 399012; -.
DR   KEGG; xla:399012; -.
DR   CTD; 399012; -.
DR   Xenbase; XB-GENE-6254655; hsd11b1l.2.S.
DR   OrthoDB; 906746at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 399012; Expressed in liver and 7 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   NADP; Oxidoreductase; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..291
FT                   /note="Hydroxysteroid 11-beta-dehydrogenase 1-like protein
FT                   A"
FT                   /id="PRO_0000316820"
FT   ACT_SITE        183
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         40..66
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         91..92
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         118..120
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         170
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         183..187
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         216..222
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   291 AA;  31753 MW;  B94E8A02181938CA CRC64;
     MAGVKLLLLS LCVGYTAYHF YSSESMNPES VRGKRVLITG SSTGIGEQIA YEFARMGAHI
     MVTARRLQRL QEVANECLKL GAASAHYVAS DMGNLTSAQY VAQEAVNKLG GLDYLVLNHI
     GGSASFGFFK GEMDPVVGSI YINFLSYVQL TSAALKALQE SQGSIVVMSS MSGRIGAPFT
     TSYCASKFAL EGFYSSLRRE FALQNSNMSV TVAVLGYIDT ENAVKKVGNK VSMSASSKED
     CAREVVKAAV LKQPELFYPY WGIKPFVLLR DWFPGLVAKI LDNFYILENI Q