ID   DHI1L_BOVIN             Reviewed;         287 AA.
AC   Q6Q7D1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Hydroxysteroid 11-beta-dehydrogenase 1-like protein;
DE            EC=1.1.1.-;
DE   AltName: Full=11-beta-hydroxysteroid dehydrogenase type 3;
DE            Short=11-DH3;
DE            Short=11-beta-HSD3;
DE   Flags: Precursor;
GN   Name=HSD11B1L; Synonyms=HSD3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Huang C.Q., Wu S.L., Zhou J.L.;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AY554049; AAS68530.1; -; mRNA.
DR   RefSeq; NP_996852.1; NM_206969.1.
DR   AlphaFoldDB; Q6Q7D1; -.
DR   SMR; Q6Q7D1; -.
DR   STRING; 9913.ENSBTAP00000002346; -.
DR   PaxDb; Q6Q7D1; -.
DR   PRIDE; Q6Q7D1; -.
DR   GeneID; 404546; -.
DR   KEGG; bta:404546; -.
DR   CTD; 374875; -.
DR   eggNOG; KOG1205; Eukaryota.
DR   HOGENOM; CLU_010194_2_7_1; -.
DR   InParanoid; Q6Q7D1; -.
DR   OrthoDB; 906746at2759; -.
DR   TreeFam; TF329114; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; NADP; Oxidoreductase; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..287
FT                   /note="Hydroxysteroid 11-beta-dehydrogenase 1-like protein"
FT                   /id="PRO_0000316815"
FT   ACT_SITE        178
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         36..62
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         87..88
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         114..116
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         165
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         178..182
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         211..217
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        280
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   287 AA;  31126 MW;  9A6B7DB156F927D7 CRC64;
     MKVLLLTGLG ALFFAYYWDD NFDPASLHGA RVLLTGVSAG IGEELAYHYA RLGSHLVLTA
     HTEALLQQVV GNCRKLGAPK VFYIAADMAS PEVPERVVQF ALDKLGGLDY LVLNHLGAAP
     AGTRVRSSQS TRWLMQMNFL SYVQLTSSAL PSLTDSKGSL VVVSSLLGRV PTSFSSPYSA
     AKFALDSFFS SLRRELDVQE VNVAITMCVL GLRDRASAAE GVRGITRVRA APGPKAALAV
     IRGGATRASG VFYPWRFHLL CLLRSWMPHS RAWFVRQELN ITTPAAA