DHI1L_DANRE
ID DHI1L_DANRE Reviewed; 287 AA.
AC Q6PUF3;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Hydroxysteroid 11-beta-dehydrogenase 1-like protein;
DE EC=1.1.1.-;
DE AltName: Full=11-beta-hydroxysteroid dehydrogenase type 3;
DE Short=11-DH3;
DE Short=11-beta-HSD3;
DE Flags: Precursor;
GN Name=hsd11b1l; Synonyms=hsd11b3, hsd3; ORFNames=si:dkey-78l4.15, zgc:56373;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Huang C.Q., Zhou J.L., Wu S.L.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; AY578180; AAS89256.1; -; mRNA.
DR EMBL; BX936298; CAK11206.1; -; Genomic_DNA.
DR EMBL; BC071452; AAH71452.1; -; mRNA.
DR EMBL; BC153593; AAI53594.1; -; mRNA.
DR RefSeq; NP_001099077.1; NM_001105607.1.
DR RefSeq; NP_956617.2; NM_200323.2.
DR AlphaFoldDB; Q6PUF3; -.
DR SMR; Q6PUF3; -.
DR STRING; 7955.ENSDARP00000061738; -.
DR PaxDb; Q6PUF3; -.
DR Ensembl; ENSDART00000061739; ENSDARP00000061738; ENSDARG00000071377.
DR Ensembl; ENSDART00000181695; ENSDARP00000155122; ENSDARG00000109751.
DR GeneID; 100006793; -.
DR GeneID; 393293; -.
DR KEGG; dre:100006793; -.
DR KEGG; dre:393293; -.
DR CTD; 393293; -.
DR ZFIN; ZDB-GENE-040426-1002; hsd11b1la.
DR eggNOG; KOG1205; Eukaryota.
DR GeneTree; ENSGT00940000162487; -.
DR HOGENOM; CLU_010194_2_1_1; -.
DR InParanoid; Q6PUF3; -.
DR OMA; ITKDWFP; -.
DR OrthoDB; 906746at2759; -.
DR PhylomeDB; Q6PUF3; -.
DR TreeFam; TF329114; -.
DR Reactome; R-DRE-194002; Glucocorticoid biosynthesis.
DR PRO; PR:Q6PUF3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 22.
DR Bgee; ENSDARG00000071377; Expressed in intestine and 23 other tissues.
DR ExpressionAtlas; Q6PUF3; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0016229; F:steroid dehydrogenase activity; ISS:ZFIN.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 2: Evidence at transcript level;
KW NADP; Oxidoreductase; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..287
FT /note="Hydroxysteroid 11-beta-dehydrogenase 1-like protein"
FT /id="PRO_0000316819"
FT ACT_SITE 182
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 40..66
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 91..92
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 118..120
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 169
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 182..186
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 215..221
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
SQ SEQUENCE 287 AA; 31918 MW; CC74BDD6D41C2CA8 CRC64;
MKLYAKLLLC SICVAFIAVR WSAPSFNEES LKGARVLVTG ASTGIGEQLA YHYARLGAQI
VITARRGNVL EQVVSKCREM GAQKAFYIPA DMANPSDADL VVKYAIEQLG GLDYLVLNHI
GPSPYQMWDG DVQHTRWLLE VNFLSYLQMA QKALPTLEKS KGSIVVVSSL LGKICGPFAL
PYASTKFALN GFFGGLQNEL AMQKSNVSIT ICILGLIDTD SAMEKIKGYI NMTAYPSHEA
ALQIIQAGAT RQSESFYPWY TFYATLFRDW FPYLRDKVIQ NSYTYNP
