ID   DHI1L_MACFA             Reviewed;         287 AA.
AC   Q6Q7D2; Q9N0C4;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Hydroxysteroid 11-beta-dehydrogenase 1-like protein;
DE            EC=1.1.1.-;
DE   AltName: Full=11-beta-hydroxysteroid dehydrogenase type 3;
DE            Short=11-DH3;
DE            Short=11-beta-HSD3;
DE   Flags: Precursor;
GN   Name=HSD11B1L; Synonyms=HSD3; ORFNames=QccE-13246;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Huang C.Q., Wu S.L., Zhou J.L.;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain cortex;
RX   PubMed=11574149; DOI=10.1016/s0378-1119(01)00665-5;
RA   Osada N., Hida M., Kususda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA   Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.;
RT   "Assignment of 118 novel cDNAs of cynomolgus monkey brain to human
RT   chromosomes.";
RL   Gene 275:31-37(2001).
RN   [3]
RP   ERRATUM OF PUBMED:11574149.
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA   Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K., Kususda J.;
RL   Gene 278:267-267(2001).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6Q7D2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6Q7D2-2; Sequence=VSP_030798, VSP_030799;
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AY554048; AAS68529.1; -; mRNA.
DR   EMBL; AB046006; BAB01588.1; -; mRNA.
DR   RefSeq; XP_005587693.1; XM_005587636.1. [Q6Q7D2-1]
DR   RefSeq; XP_015295757.1; XM_015440271.1. [Q6Q7D2-2]
DR   AlphaFoldDB; Q6Q7D2; -.
DR   SMR; Q6Q7D2; -.
DR   STRING; 9541.XP_005587680.1; -.
DR   GeneID; 102133758; -.
DR   KEGG; mcf:102133758; -.
DR   CTD; 374875; -.
DR   VEuPathDB; HostDB:ENSMFAG00000044973; -.
DR   eggNOG; KOG1205; Eukaryota.
DR   OMA; ITKDWFP; -.
DR   Proteomes; UP000233100; Chromosome 19.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; NADP; Oxidoreductase; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..287
FT                   /note="Hydroxysteroid 11-beta-dehydrogenase 1-like protein"
FT                   /id="PRO_0000316817"
FT   ACT_SITE        178
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         36..62
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         87..88
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         114..116
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         165
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         178..182
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         211..217
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         1..87
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11574149"
FT                   /id="VSP_030798"
FT   VAR_SEQ         135
FT                   /note="M -> MQAPPLPVTRECHL (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11574149"
FT                   /id="VSP_030799"
SQ   SEQUENCE   287 AA;  30945 MW;  624B7817AD151C57 CRC64;
     MKVLLLTGLG ALFFAYYWDD NFDPASLQGA RVLLTGASAG VGEELAYHYA RLGSHLVLTA
     HTEALLQKVV GNCRKLGAPK VFYIAADMAS PEAPESVVQF ALDKLGGLDY LVLNHIGGVP
     AGTRARTPQA TRWLMQVNFL SYVQLTSRAL PSLTDSKGSL VVVSSLLGRV PTSFSTPYSA
     AKFALDSFFG SLRRELDVQD VNVAITMCVL GLRDRASAAE AVRGVTRVKA APGPKAALAV
     IRGGATRAAG VFYPWRFHLL CLLRRWLPRP RAWFIRQDLN VTAAAAA