ID   DHI1L_XENTR             Reviewed;         286 AA.
AC   A4IGM4;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Hydroxysteroid 11-beta-dehydrogenase 1-like protein;
DE            EC=1.1.1.-;
DE   AltName: Full=11-beta-hydroxysteroid dehydrogenase type 3;
DE            Short=11-DH3;
DE            Short=11-beta-HSD3;
DE   Flags: Precursor;
GN   Name=hsd11b1l; Synonyms=hsd3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; BC135167; AAI35168.1; -; mRNA.
DR   RefSeq; NP_001090784.1; NM_001097315.1.
DR   AlphaFoldDB; A4IGM4; -.
DR   SMR; A4IGM4; -.
DR   STRING; 8364.ENSXETP00000031363; -.
DR   PaxDb; A4IGM4; -.
DR   DNASU; 100037875; -.
DR   GeneID; 100037875; -.
DR   KEGG; xtr:100037875; -.
DR   CTD; 374875; -.
DR   Xenbase; XB-GENE-5851849; hsd11b1l.
DR   eggNOG; KOG1205; Eukaryota.
DR   HOGENOM; CLU_010194_2_1_1; -.
DR   InParanoid; A4IGM4; -.
DR   OrthoDB; 906746at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000014342; Expressed in male organism and 3 other tissues.
DR   ExpressionAtlas; A4IGM4; differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   NADP; Oxidoreductase; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..286
FT                   /note="Hydroxysteroid 11-beta-dehydrogenase 1-like protein"
FT                   /id="PRO_0000316822"
FT   ACT_SITE        181
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         39..65
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         90..91
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         117..119
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         168
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         181..185
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         214..220
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   286 AA;  32162 MW;  B76327F35BBD48A2 CRC64;
     MGIHIKRWCF IILVASAAYI LRDSFDPETL ANTRVLVTGA STGIGEEIAY HYARAGAKLV
     LTARREHALQ EVKSRCLELG AKNVFLVVAD MASHNAREQV VAEALSALGG LDYLVLNHIG
     WTPFKMWDGD VNHTRWLMEV NFLSYIHLAT AALPYLTQSK GSIIVLSSLT AKTPIPYTTS
     YAASKFALEG FFSSLRHELT MQNNPVSITL CILGLIDTQS AMEKIKDKIT MSAYPASDAA
     LAVVSAGAGR QREMYYPWFV RPLCFFRDWF PQHRDWFIQR MYHYNS