ADAM5_HUMAN
ID ADAM5_HUMAN Reviewed; 412 AA.
AC Q6NVV9; A8MW71; Q4G196;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 2.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Putative disintegrin and metalloproteinase domain-containing protein 5;
DE AltName: Full=Putative transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II;
DE Short=tMDC II;
GN Name=ADAM5; Synonyms=ADAM5P, TMDC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5; 6 AND 7), FUNCTION, TISSUE
RP SPECIFICITY, AND ALTERNATIVE SPLICING.
RX PubMed=10417343; DOI=10.1042/bj3410771;
RA Frayne J., Dimsey E.A., Jury J.A., Hall L.;
RT "Transcripts encoding the sperm surface protein tMDC II are non-functional
RT in the human.";
RL Biochem. J. 341:771-775(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: This is a non catalytic metalloprotease-like protein.
CC {ECO:0000250, ECO:0000269|PubMed:10417343}.
CC -!- SUBUNIT: Interacts with TEX101. {ECO:0000250|UniProtKB:Q3TTE0}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=7;
CC Name=1;
CC IsoId=Q6NVV9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NVV9-2; Sequence=VSP_035340, VSP_035343, VSP_035344;
CC Name=3;
CC IsoId=Q6NVV9-3; Sequence=VSP_035339, VSP_035341;
CC Name=4;
CC IsoId=Q6NVV9-4; Sequence=VSP_035340;
CC Name=5;
CC IsoId=Q6NVV9-5; Sequence=VSP_035340, VSP_035342;
CC Name=6;
CC IsoId=Q6NVV9-6; Sequence=VSP_035345;
CC Name=7;
CC IsoId=Q6NVV9-7; Sequence=VSP_035346;
CC -!- TISSUE SPECIFICITY: Highly expressed in testis.
CC {ECO:0000269|PubMed:10417343}.
CC -!- CAUTION: Could be the product of a pseudogene. Not expected to have
CC protease activity. {ECO:0000305}.
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DR EMBL; AJ132820; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AJ132821; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AJ132822; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AJ132823; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AJ132824; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AJ132825; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AJ132826; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AJ132827; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC105185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC026083; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC067864; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q6NVV9; -.
DR SMR; Q6NVV9; -.
DR GlyGen; Q6NVV9; 1 site, 1 O-linked glycan (1 site).
DR BioMuta; HGNC:212; -.
DR DMDM; 121946258; -.
DR PRIDE; Q6NVV9; -.
DR TopDownProteomics; Q6NVV9-7; -. [Q6NVV9-7]
DR GeneCards; ADAM5; -.
DR HGNC; HGNC:212; ADAM5.
DR neXtProt; NX_Q6NVV9; -.
DR InParanoid; Q6NVV9; -.
DR PhylomeDB; Q6NVV9; -.
DR ChiTaRS; ADAM5; human.
DR Pharos; Q6NVV9; Tdark.
DR PRO; PR:Q6NVV9; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q6NVV9; protein.
DR GO; GO:0007339; P:binding of sperm to zona pellucida; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR Gene3D; 4.10.70.10; -; 1.
DR InterPro; IPR006586; ADAM_Cys-rich.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR002870; Peptidase_M12B_N.
DR Pfam; PF08516; ADAM_CR; 1.
DR Pfam; PF01562; Pep_M12B_propep; 1.
DR SMART; SM00608; ACR; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; SSF57552; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 5: Uncertain;
KW Alternative splicing; EGF-like domain; Reference proteome.
FT CHAIN 1..412
FT /note="Putative disintegrin and metalloproteinase domain-
FT containing protein 5"
FT /id="PRO_0000349304"
FT DOMAIN 111..199
FT /note="Disintegrin"
FT DOMAIN 351..385
FT /note="EGF-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT VAR_SEQ 1..84
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:10417343"
FT /id="VSP_035339"
FT VAR_SEQ 1..57
FT /note="Missing (in isoform 2, isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:10417343,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_035340"
FT VAR_SEQ 85..162
FT /note="TMQLKNISYGIEPMEAVSGFIHKIYEEKYADTNILLEENDTYTWFNSEYQVR
FT KSSEKTDFIKLFPRYIEMHIVVDKNL -> MTLILGLIQSIKSEKVQKYSGGVKDFNIC
FT SLDDFKYISSHNGLTCLQTNPLEMPHRRICGNGLLEGSEECDCGTKD (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:10417343"
FT /id="VSP_035341"
FT VAR_SEQ 141..162
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:10417343"
FT /id="VSP_035342"
FT VAR_SEQ 163..170
FT /note="FKPANMIC -> VLWWCKGF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10417343,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_035343"
FT VAR_SEQ 171..412
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10417343,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_035344"
FT VAR_SEQ 337..365
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:10417343"
FT /id="VSP_035345"
FT VAR_SEQ 404..412
FT /note="ERSYMEEGR -> APVS (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:10417343"
FT /id="VSP_035346"
SQ SEQUENCE 412 AA; 47181 MW; 8F1E8FC241CFD471 CRC64;
MQTSILIKSS CRPQFQRRFH HRMQKQIQNI ISILSSASVI NSYDENDIRH SKPLLVQMDC
NYNGYVAGIP NSLVTLSVCS GLRGTMQLKN ISYGIEPMEA VSGFIHKIYE EKYADTNILL
EENDTYTWFN SEYQVRKSSE KTDFIKLFPR YIEMHIVVDK NLFKPANMIC RKSVGKECDF
TEYCNGDLPY CLPDTYVRDG EYCDSGGAFC FQGKCRTFDK QCDDLIGRGS RGAPVFCYDE
INTRGDNFGN CGTAHCLFQH ILCGKLVCTW EHRDLISRPN LSVIYAHVRD QTCVSTYLPR
RTPPPVNSPI SITSYYSAED RDETFVQDGS MCGPDMYCFE MHCKHVRFLM NLKLCDASNH
CDRHGVCNNF NHCHCEKGYN PPYCQPKQGA FGSIDDGHLV PPTERSYMEE GR
