DHKF_DICDI
ID DHKF_DICDI Reviewed; 1109 AA.
AC Q551X9; Q86IA0; Q95PI0;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Hybrid signal transduction histidine kinase F;
DE EC=2.7.13.3;
GN Name=dhkF; ORFNames=DDB_G0276143;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AX4;
RA Anjard C., Loomis W.F.;
RT "The histidine kinases of Dictyostelium.";
RL (In) Inouye M., Dutta R. (eds.);
RL Histidine kinases in signal transduction, pp.1-1, Academic press, San Diego
RL (2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Acts as a receptor histidine kinase for a signal transduction
CC pathway. This protein undergoes an ATP-dependent autophosphorylation at
CC a conserved histidine residue in the kinase core, and a phosphoryl
CC group is then transferred to a conserved aspartate residue in the
CC receiver domain (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3;
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DR EMBL; AF362368; AAK54087.2; -; Genomic_DNA.
DR EMBL; AAFI02000014; EAL69371.1; -; Genomic_DNA.
DR RefSeq; XP_643349.1; XM_638257.1.
DR AlphaFoldDB; Q551X9; -.
DR SMR; Q551X9; -.
DR STRING; 44689.DDB0185098; -.
DR PaxDb; Q551X9; -.
DR EnsemblProtists; EAL69371; EAL69371; DDB_G0276143.
DR GeneID; 8620399; -.
DR KEGG; ddi:DDB_G0276143; -.
DR dictyBase; DDB_G0276143; dhkF.
DR eggNOG; KOG0519; Eukaryota.
DR HOGENOM; CLU_282062_0_0_1; -.
DR InParanoid; Q551X9; -.
DR OMA; KSYMEIP; -.
DR PhylomeDB; Q551X9; -.
DR PRO; PR:Q551X9; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF47384; SSF47384; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR SUPFAM; SSF55785; SSF55785; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00229; sensory_box; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Kinase; Nucleotide-binding; Phosphoprotein;
KW Reference proteome; Transducer; Transferase;
KW Two-component regulatory system.
FT CHAIN 1..1109
FT /note="Hybrid signal transduction histidine kinase F"
FT /id="PRO_0000375998"
FT DOMAIN 237..289
FT /note="PAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00141"
FT DOMAIN 324..547
FT /note="Histidine kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT DOMAIN 928..1048
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT REGION 739..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1052..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 719..760
FT /evidence="ECO:0000255"
FT COMPBIAS 739..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..786
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 327
FT /note="Phosphohistidine; by autocatalysis"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT MOD_RES 977
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT CONFLICT 54
FT /note="K -> KVC (in Ref. 1; AAK54087)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1109 AA; 125421 MW; 42A2586314902434 CRC64;
MILKFIIQQC VFKVAKIFSD NLIQIFMDIS SVYSSSTLFF SKLSLLMCKV FNSKCAGISV
LNKDGLFDTI AFCSSTQELE NFSYSLKKIS KNITYYDNIN EIFNNSEIIK KYNLKSYMEI
PLKDSKEFYF GDIVLFGDQT LNPNILDTNI LTFITNRTSM EFEKKKVSDQ LIIAKNLLDQ
SPSCSCLVSR NGKIIRKIGA FYERLLGLEI GENISSVEKS SDISTILKQV CFENNNLSTE
TTITKKNGEK YPAEVFVKEI SDIHSNSIGI MIIVRDITDQ IRLKEMNIEL QKKSELEQKR
NQELMEARDL ALTATKIKSQ FLATISHEIR TPLNGIITMG EMLLSTSPLN TEQHDIAETI
FGSSELLLSI TSDILDFSKI EASKLELEMI EFDFIGCLEG IGKTIGVSIT NKPIEIAFLM
DTDIPHRLIG DPNRLIQIML NMGTNAVKYT DRGHIVFRIS VISREQNRCK IKISIDDSGI
GIGEDQRAHL FEPFHQIDSS STRKYGGSGL GLAISSKLAK LMGGEVILER SKPGVGSLFS
VTLNFEQIGS NTLKSLLPDK SFSRNKTCII LDNYEYTASI ASQRFDQIFE ESNIILVKES
TVKKFFELVQ EYKINGDVNK IDLKNLDPEL LPFFDSSLIC IIVFHRFMDN LDIFLKYVKD
FIEFYKKKIV VALGINHKNF KNLPKRRDFL IFKKPISSTN LIKVSNMARK IIPKSSSSSN
LIQTISQIDN QQQQQQQQLQ QQEQEQQHQQ QQLQQEQQFV TISPHSDSSE KKTTPKKDRG
KYDFNISPLR IDRFGTESTS SPKIKLYSDT SSDSGESDEF EFSENLRELK SDGELVVLKN
QPYKEQRLSN IQLINDPIVT PPTPKANSEV VSTKAESTFF QSSSITIKET RSDSVNSVNS
VNSVNSVNSL NSENSNNSLD VGIRTRPRIL LVDDNAVNRK VVKLQLKKLG YDCDTATNGF
EGFEMQKKDN YELIFMDLNM PLCDGSMASK LIRSHEELNN YKSRANIVGL SATYLHGSKD
YCVSMGMDDF VVKPLKLQPL GELVKKYLEV ENNNNNNNNN NNNNNNNNSN NNNSNSNSNP
NSNSNSNSNS NSNPNQNPNY CNNLPTDFI
