ID   DHPS2_MYCBO             Reviewed;         318 AA.
AC   P64140; A0A1R3XXN2; O05308; X2BHD4;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Inactive dihydropteroate synthase 2;
DE            Short=DHPS 2;
DE   AltName: Full=Dihydropteroate pyrophosphorylase 2;
GN   Name=folP2; OrderedLocusNames=BQ2027_MB1239;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Has very low affinity for the DHPS substrate 6-hydroxymethyl-
CC       7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone.
CC       Seems to lack dihydropteroate synthase activity, and does probably not
CC       function in folate metabolism (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DHPS family. {ECO:0000305}.
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DR   EMBL; LT708304; SIT99840.1; -; Genomic_DNA.
DR   RefSeq; NP_854893.1; NC_002945.3.
DR   RefSeq; WP_003406241.1; NC_002945.4.
DR   AlphaFoldDB; P64140; -.
DR   SMR; P64140; -.
DR   EnsemblBacteria; SIT99840; SIT99840; BQ2027_MB1239.
DR   GeneID; 45425177; -.
DR   PATRIC; fig|233413.5.peg.1359; -.
DR   OMA; DPGHDFG; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0004156; F:dihydropteroate synthase activity; IEA:InterPro.
DR   GO; GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
DR   CDD; cd00739; DHPS; 1.
DR   Gene3D; 3.20.20.20; -; 1.
DR   InterPro; IPR045031; DHP_synth.
DR   InterPro; IPR006390; DHP_synth_dom.
DR   InterPro; IPR011005; Dihydropteroate_synth-like.
DR   InterPro; IPR000489; Pterin-binding_dom.
DR   PANTHER; PTHR20941; PTHR20941; 1.
DR   Pfam; PF00809; Pterin_bind; 1.
DR   SUPFAM; SSF51717; SSF51717; 1.
DR   TIGRFAMs; TIGR01496; DHPS; 1.
DR   PROSITE; PS00792; DHPS_1; 1.
DR   PROSITE; PS00793; DHPS_2; 1.
DR   PROSITE; PS50972; PTERIN_BINDING; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..318
FT                   /note="Inactive dihydropteroate synthase 2"
FT                   /id="PRO_0000168212"
FT   DOMAIN          42..299
FT                   /note="Pterin-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00334"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            220
FT                   /note="Characteristic for family members without
FT                   dihydropteroate synthase activity"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   318 AA;  33046 MW;  918057B69AAA8E65 CRC64;
     MRSTPPASAG RSTPPALAGH STPPALAGHS TLCGRPVAGD RALIMAIVNR TPDSFYDKGA
     TFSDAAARDA VHRAVADGAD VIDVGGVKAG PGERVDVDTE ITRLVPFIEW LRGAYPDQLI
     SVDTWRAQVA KAACAAGADL INDTWGGVDP AMPEVAAEFG AGLVCAHTGG ALPRTRPFRV
     SYGTTTRGVV DAVISQVTAA AERAVAAGVA REKVLIDPAH DFGKNTFHGL LLLRHVADLV
     MTGWPVLMAL SNKDVVGETL GVDLTERLEG TLAATALAAA AGARMFRVHE VAATRRVLEM
     VASIQGVRPP TRTVRGLA