ADAR_ASPNC
ID ADAR_ASPNC Reviewed; 777 AA.
AC A2QX26;
DT 13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=C6 finger domain transcription factor adaR {ECO:0000303|PubMed:21866960};
DE AltName: Full=2-acetyl-2-decarboxamidoanthrotainin biosynthesis cluster protein R {ECO:0000303|PubMed:21866960};
GN Name=adaR {ECO:0000303|PubMed:21866960}; ORFNames=An11g07350;
OS Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
RN [2]
RP IDENTIFICATION, AND FUNCTION.
RX PubMed=21866960; DOI=10.1021/ja206906d;
RA Li Y., Chooi Y.H., Sheng Y., Valentine J.S., Tang Y.;
RT "Comparative characterization of fungal anthracenone and naphthacenedione
RT biosynthetic pathways reveals an alpha-hydroxylation-dependent Claisen-like
RT cyclization catalyzed by a dimanganese thioesterase.";
RL J. Am. Chem. Soc. 133:15773-15785(2011).
CC -!- FUNCTION: Transcription factor that specifically regulates the
CC expression of the ada gene cluster involved in the biosynthesis of the
CC linear tetracyclic TAN-1612 neuropeptide Y receptor antagonist.
CC {ECO:0000269|PubMed:21866960}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR EMBL; AM270243; CAK40782.1; -; Genomic_DNA.
DR AlphaFoldDB; A2QX26; -.
DR PaxDb; A2QX26; -.
DR EnsemblFungi; CAK40782; CAK40782; An11g07350.
DR VEuPathDB; FungiDB:An11g07350; -.
DR HOGENOM; CLU_004083_7_1_1; -.
DR Proteomes; UP000006706; Chromosome 7R.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..777
FT /note="C6 finger domain transcription factor adaR"
FT /id="PRO_0000446342"
FT DNA_BIND 24..50
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..677
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 85148 MW; EB31D93F1AD507BD CRC64;
MEQRSSPARS LPPRKTTTTP QLSCELCRKR KVKCDKLTPC TNCAASGTVC VPIYRTRLPR
GRHATRPRRV SSPPPTSAPG ETDRIIQPSV PVNEDLQERI YRLEALIQGM NSHSHTRTPS
ATSREQSVQL SDTSTFQTAP NPNTSPILNS SIVSKRLMLQ RPDQFWADLV DEIHGLREVV
ESSLAGGQEG PIPSSDSAKS EPPNDDGIQV LGLGASNPSA ALRSMSPLHN PVVARQLCEV
YLQQVDPVIK ILHRPSLNRW MVQGEPYLSY ADGHPAVEAL GSAVCYSAIS SMTDNQCSVM
FHANKADLLA EARVACETAI GRAGLLTTRD ITVLQAFVLY LVARRSEDRT PAVWTLIALA
VRIGKGLGLY LDPETETFFD QQIRRRLWFT ICLMDLQASF GQASEPLISV DESASTALPQ
HINDSDFDPT TAAHSDPNRE GLTDTTFALV TYHAQRTGRL LNFVQHDRKV DGGIPTPTSS
TSGTSTSRSR TCDPSWPQQQ ARHFEQEALR LLHFCDPGTS AYAWFTWHGT QSLIATVRLA
AARPLQWHGQ APPPRREGNT ELLRLCLPVL EKAQLMHTDP RAEGFRWYVT IPWYALAMAL
AECYVSSDTA LVRYAWPLVE SSYLQYEATL GQSLGGPFGQ LMRRMKEKLA APAALPPSSL
PSTNWSPATP PTFPGVPRPQ SSHDDRHAPG CSWPVPTGST PPADLGVPSL LPVSTWEALS
PPSLDNPSLF GVPPTTTAVA DGMDPGADIM WEELFSGIPF NEIAGPDTFF FDMNWGS
