ID   DHQSH_AQUAE             Reviewed;         331 AA.
AC   O67751;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=3-dehydroquinate synthase homolog {ECO:0000255|HAMAP-Rule:MF_01244};
DE            EC=1.4.1.- {ECO:0000255|HAMAP-Rule:MF_01244};
GN   OrderedLocusNames=aq_1922;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- SIMILARITY: Belongs to the archaeal-type DHQ synthase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01244}.
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DR   EMBL; AE000657; AAC07721.1; -; Genomic_DNA.
DR   PIR; C70465; C70465.
DR   RefSeq; NP_214319.1; NC_000918.1.
DR   RefSeq; WP_010881255.1; NC_000918.1.
DR   AlphaFoldDB; O67751; -.
DR   STRING; 224324.aq_1922; -.
DR   EnsemblBacteria; AAC07721; AAC07721; aq_1922.
DR   KEGG; aae:aq_1922; -.
DR   PATRIC; fig|224324.8.peg.1489; -.
DR   eggNOG; COG1465; Bacteria.
DR   HOGENOM; CLU_056379_0_0_0; -.
DR   InParanoid; O67751; -.
DR   OMA; HFGMAIK; -.
DR   OrthoDB; 764330at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0003856; F:3-dehydroquinate synthase activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016639; F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor; IEA:UniProtKB-UniRule.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_01244; Arch_DHQ_synthase; 1.
DR   InterPro; IPR002812; DHQ_synth.
DR   PANTHER; PTHR33563; PTHR33563; 1.
DR   Pfam; PF01959; DHQS; 1.
DR   PIRSF; PIRSF006655; DHQ_synth; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; NAD;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..331
FT                   /note="3-dehydroquinate synthase homolog"
FT                   /id="PRO_0000058765"
SQ   SEQUENCE   331 AA;  37048 MW;  05C5EC8DB00CB2B8 CRC64;
     MKEFWVWVEP FDRKIVSVAL EAGANAVVIP EKGRVEEVKK VGRITVIAPD GDLKLGEDVV
     YVLIKGKEDE ERAAKYPPNV KVIVETTDWT VIPLENLIAQ REELYAVVKN AQEAEVALQT
     LEKGVKGVVL KSRDINEIKK VGQIVSEHEE KLELVTIKIT KILPLGLGDR VCVDTISLLH
     RGEGMLVGNS SGGMFLVHAE TEENPYVAAR PFRVNAGAVH MYIRVPNNRT KYLCELKAGD
     KVMVYDYKGR GRVTYVGRAK VERRPMLLIE GRYENKKLSC ILQNAETIRL TKPDGTPISV
     SELKEGDEVL GYVEEAGRHF GMKVEETIIE K