ID   DHQS_METAR              Reviewed;         374 AA.
AC   Q0W131;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=3-dehydroquinate synthase {ECO:0000255|HAMAP-Rule:MF_01244};
DE            Short=DHQ synthase {ECO:0000255|HAMAP-Rule:MF_01244};
DE            EC=1.4.1.24 {ECO:0000255|HAMAP-Rule:MF_01244};
DE   AltName: Full=3-dehydroquinate synthase II {ECO:0000255|HAMAP-Rule:MF_01244};
GN   Name=aroB' {ECO:0000255|HAMAP-Rule:MF_01244};
GN   OrderedLocusNames=UNCMA_03530; ORFNames=RRC152;
OS   Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=351160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22066 / NBRC 105507 / MRE50;
RX   PubMed=16857943; DOI=10.1126/science.1127062;
RA   Erkel C., Kube M., Reinhardt R., Liesack W.;
RT   "Genome of rice cluster I archaea -- the key methane producers in the rice
RT   rhizosphere.";
RL   Science 313:370-372(2006).
CC   -!- FUNCTION: Catalyzes the oxidative deamination and cyclization of 2-
CC       amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-
CC       dehydroquinate (DHQ), which is fed into the canonical shikimic pathway
CC       of aromatic amino acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01244}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+)
CC         = 3-dehydroquinate + H(+) + NADH + NH4(+); Xref=Rhea:RHEA:25956,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:32364, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:58859; EC=1.4.1.24; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01244};
CC   -!- SIMILARITY: Belongs to the archaeal-type DHQ synthase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01244}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM114193; CAJ37912.1; -; Genomic_DNA.
DR   RefSeq; WP_012034682.1; NC_009464.1.
DR   AlphaFoldDB; Q0W131; -.
DR   STRING; 351160.RRC152; -.
DR   EnsemblBacteria; CAJ37912; CAJ37912; RRC152.
DR   GeneID; 5145217; -.
DR   KEGG; rci:RRC152; -.
DR   PATRIC; fig|351160.9.peg.371; -.
DR   eggNOG; arCOG04353; Archaea.
DR   OMA; HFGMAIK; -.
DR   OrthoDB; 29853at2157; -.
DR   Proteomes; UP000000663; Chromosome.
DR   GO; GO:0003856; F:3-dehydroquinate synthase activity; IEA:InterPro.
DR   GO; GO:0102042; F:dehydroquinate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_01244; Arch_DHQ_synthase; 1.
DR   InterPro; IPR002812; DHQ_synth.
DR   PANTHER; PTHR33563; PTHR33563; 1.
DR   Pfam; PF01959; DHQS; 1.
DR   PIRSF; PIRSF006655; DHQ_synth; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; NAD;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..374
FT                   /note="3-dehydroquinate synthase"
FT                   /id="PRO_1000067071"
SQ   SEQUENCE   374 AA;  39830 MW;  F73798EC2B784DA1 CRC64;
     MSDKLVWIDA QGSWNGAKEK VTGALESGAN AVLVSPENVE RVRELGKMTV AAAEGNPDIR
     VIGIGSEGDG TLFLPHDLNS SEDMATAKAL KAQGTTTAAY VRLAGKEYEQ FAARMGKLCD
     YLIIEGDDWK VIPLENLIAE LGGSGTKILA KARDIDEASV ALQTLEKGAD GVLVDVDDPL
     KVREIARAVS TKQAGLGLTP VTITAVRDAG TGDRVCIDTC SLMTPGEGML IGNQSSGLFL
     VQSEAEESPY VASRPFRVNA GAVHEYVLVG EKTRYLSELA SGDPALIVTR DGDARKATIG
     RVKIERRPLL YVEAETGDRK ISAILQNAET IKLVAADGSS TPVTALKPGD RVLAKLEKEA
     RHFGMKIEET IVEK