ID   DHQS_METJA              Reviewed;         361 AA.
AC   Q58646;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=3-dehydroquinate synthase;
DE            Short=DHQ synthase;
DE            EC=1.4.1.24;
DE   AltName: Full=3-dehydroquinate synthase II;
GN   Name=aroB'; OrderedLocusNames=MJ1249;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   FUNCTION AS A DHQ SYNTHASE, AND CATALYTIC ACTIVITY.
RX   PubMed=15182204; DOI=10.1021/bi0495127;
RA   White R.H.;
RT   "L-aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the
RT   precursors to the aromatic amino acids in Methanocaldococcus jannaschii.";
RL   Biochemistry 43:7618-7627(2004).
CC   -!- FUNCTION: Catalyzes the oxidative deamination and cyclization of 2-
CC       amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-
CC       dehydroquinate (DHQ), which is fed into the canonical shikimic pathway
CC       of aromatic amino acid biosynthesis. {ECO:0000269|PubMed:15182204}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+)
CC         = 3-dehydroquinate + H(+) + NADH + NH4(+); Xref=Rhea:RHEA:25956,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:32364, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:58859; EC=1.4.1.24;
CC         Evidence={ECO:0000269|PubMed:15182204};
CC   -!- SIMILARITY: Belongs to the archaeal-type DHQ synthase family.
CC       {ECO:0000305}.
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DR   EMBL; L77117; AAB99252.1; -; Genomic_DNA.
DR   PIR; H64455; H64455.
DR   RefSeq; WP_010870761.1; NC_000909.1.
DR   AlphaFoldDB; Q58646; -.
DR   SMR; Q58646; -.
DR   STRING; 243232.MJ_1249; -.
DR   DNASU; 1452146; -.
DR   EnsemblBacteria; AAB99252; AAB99252; MJ_1249.
DR   GeneID; 1452146; -.
DR   KEGG; mja:MJ_1249; -.
DR   eggNOG; arCOG04353; Archaea.
DR   HOGENOM; CLU_056379_0_0_2; -.
DR   InParanoid; Q58646; -.
DR   OMA; HFGMAIK; -.
DR   OrthoDB; 29853at2157; -.
DR   PhylomeDB; Q58646; -.
DR   BioCyc; MetaCyc:MON-14595; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0003856; F:3-dehydroquinate synthase activity; IEA:InterPro.
DR   GO; GO:0102042; F:dehydroquinate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_01244; Arch_DHQ_synthase; 1.
DR   InterPro; IPR002812; DHQ_synth.
DR   PANTHER; PTHR33563; PTHR33563; 1.
DR   Pfam; PF01959; DHQS; 1.
DR   PIRSF; PIRSF006655; DHQ_synth; 1.
PE   1: Evidence at protein level;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; NAD;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..361
FT                   /note="3-dehydroquinate synthase"
FT                   /id="PRO_0000058769"
SQ   SEQUENCE   361 AA;  40260 MW;  8A072D5A4712D7FE CRC64;
     MKFGWVNVIG DNWEEKKKIV TTALESSIPV VVAEPEDIEK IKELGNIKVA SHSLDADIVL
     VNKNDNIEFL KEAKNLGKET AIYIPIESKE DEEFASEVAR FGFVDNIILE GRDWTIIPLE
     NLIADLFHRD VKIVASVNSV DEAKVAYEIL EKGTDGVLLN PKNLEDIKEL SKLIEEMNKE
     KVALDVATVT KVEPIGSGDR VCIDTCSLMK IGEGMLIGSY SRALFLVHSE TVENPYVATR
     PFRVNAGPVH AYILCPGNKT KYLSELKAGD KVLIVDKDGN TREAIVGRVK IERRPLVLIE
     AEYKGDIIRT ILQNAETIRL VNEKGEPISV VDLKPGDKVL IKPEEYARHF GMAIKETIIE
     K