ID   DHS27_CAEEL             Reviewed;         816 AA.
AC   Q11177; D7SFL0;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Uncharacterized oxidoreductase dhs-27;
DE            EC=1.-.-.-;
DE   AltName: Full=Short-chain dehydrogenase 27;
GN   Name=dhs-27; ORFNames=C04F6.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCD63032.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; FO080344; CCD63032.1; ALT_SEQ; Genomic_DNA.
DR   PIR; T15411; T15411.
DR   RefSeq; NP_508591.3; NM_076190.3.
DR   AlphaFoldDB; Q11177; -.
DR   STRING; 6239.C04F6.5; -.
DR   EPD; Q11177; -.
DR   PaxDb; Q11177; -.
DR   PeptideAtlas; Q11177; -.
DR   EnsemblMetazoa; C04F6.5.1; C04F6.5.1; WBGene00000990.
DR   GeneID; 180632; -.
DR   KEGG; cel:CELE_C04F6.5; -.
DR   UCSC; C04F6.5; c. elegans.
DR   CTD; 180632; -.
DR   WormBase; C04F6.5; CE45036; WBGene00000990; dhs-27.
DR   eggNOG; KOG1014; Eukaryota.
DR   GeneTree; ENSGT00940000160053; -.
DR   InParanoid; Q11177; -.
DR   OrthoDB; 895581at2759; -.
DR   PRO; PR:Q11177; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00000990; Expressed in embryo and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015897; CHK_kinase-like.
DR   InterPro; IPR012877; Dhs-27.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   Pfam; PF07914; DUF1679; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SMART; SM00587; CHK; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   Membrane; NADP; Oxidoreductase; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..816
FT                   /note="Uncharacterized oxidoreductase dhs-27"
FT                   /id="PRO_0000054879"
FT   TRANSMEM        743..763
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        777..797
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        661
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         503..534
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         641
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   816 AA;  93989 MW;  772A228F0FBE1B43 CRC64;
     MESKVVALNR ESRRWKKSSF NELLKRARNQ KSTICNRFTR KNTPNILVTF TSRLTLLRPT
     FFNFACWHSA MEIFESMSFS VKFDKELLPI GRHGLTAGWL IESLGQLLNS DNIRNIKCSQ
     LGTDGFVSQI MRVVIEFTNN QTKKYIVKMP ETTNIKAALE KTTQQKMPEG ADEQFIGGLT
     MFFNREVEYY AMEKIPGLRT PKCYHAQQWD NGKTTGAIVM QDLEGMVSVP YYESLNLQQI
     ASIGSQMLNL HLFSIGMSDE WRQKFPFPME LIDTVSNMTD IVKLYVSRNP ELEEGFSKVE
     KMYQDRELFT KVLRDSHKSL GIDDFLCHGD LWFYNLMWIP RKSGSEVASN HLGSIIDWQN
     VHTGNICEDF CHMLTFCCDT EIRRQAENTF LPYYYNQLKA KAVEAGKKLN LTLNQFLRAY
     RRNFIAHALH LPFIVSIMLC VKPADDEIVQ KIRNQMSGAL WSAAQFAVTS YVCVRVLKFL
     YIMCKSVLVH FITPKHDLDY LKDTWTVITG GTDGIGKAYI EELCKTRGLK KFYLIGRNID
     KLNNTKKELV EQHGCEVMCH VHDFEKDDLS ALPKDLETLD VGILINCAGI APHIIGTLTE
     LPEGLASKIL RVNLMSAVKM TEMILPNMVK KKRGIIVNIS SMTGWRRFRT SVLTRLAKLH
     YPSSPTPCQM NTEELEFVFS VSFQCSLLPR SPRMKLKKRT ISSLSPLKTL PNKLSELSGL
     IGKSQRAVCN MMFRLPLEHC SPFGFSKYFS SLLLCSEFIS IVLPLIKRRT RERIIRVFII
     SRLSIFVHFY HDFFLLNAIF QIKKFSCELN FLESFF