ID   DHS5_CAEEL              Reviewed;         378 AA.
AC   Q10130;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2002, sequence version 2.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Uncharacterized oxidoreductase dhs-5;
DE            EC=1.-.-.-;
DE   AltName: Full=Short-chain dehydrogenase 5;
GN   Name=dhs-5; ORFNames=F56D1.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; FO081078; CCD68960.1; -; Genomic_DNA.
DR   RefSeq; NP_495035.1; NM_062634.3.
DR   AlphaFoldDB; Q10130; -.
DR   SMR; Q10130; -.
DR   BioGRID; 39274; 4.
DR   IntAct; Q10130; 1.
DR   STRING; 6239.F56D1.5; -.
DR   EPD; Q10130; -.
DR   PaxDb; Q10130; -.
DR   PeptideAtlas; Q10130; -.
DR   EnsemblMetazoa; F56D1.5.1; F56D1.5.1; WBGene00000969.
DR   GeneID; 173930; -.
DR   KEGG; cel:CELE_F56D1.5; -.
DR   UCSC; F56D1.5; c. elegans.
DR   CTD; 173930; -.
DR   WormBase; F56D1.5; CE28036; WBGene00000969; dhs-5.
DR   eggNOG; KOG1014; Eukaryota.
DR   HOGENOM; CLU_010194_38_0_1; -.
DR   InParanoid; Q10130; -.
DR   OMA; PLFYKPN; -.
DR   OrthoDB; 895581at2759; -.
DR   PhylomeDB; Q10130; -.
DR   Reactome; R-CEL-193048; Androgen biosynthesis.
DR   Reactome; R-CEL-75876; Synthesis of very long-chain fatty acyl-CoAs.
DR   PRO; PR:Q10130; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00000969; Expressed in larva and 3 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Membrane; Oxidoreductase; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..378
FT                   /note="Uncharacterized oxidoreductase dhs-5"
FT                   /id="PRO_0000054878"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        238
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         225
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   378 AA;  42076 MW;  DCA2F95F42628093 CRC64;
     MAPTPPPPLS STLIPEESST SFFASLHSLL PTFHVENGAQ LAVTMLLLIP VVYVGYRLYR
     TFFAFLKAIF IYTIAPLFYK PNLEQYQHRW TVVSGGTDGI GKAYTLELAK RGLRKFVLIG
     RNPKKLDSVK SEIEEKHSDA QIKTFVFDFG SGDFSSLRDY ISDIDVGFVV NSVGTGRDNL
     ERYGDNPDED TQILRVNGMG AAEFLSCVLP PMEKSGGGQI VVLSSSQGVR PIPMLAAYCA
     TKALMTFLCE SIDREYSTIN VQTLIPALVA TKMTYYTKGS TFVVTPENFC HQAVGSIGLT
     KKTAGCLNHE LQMLGFHLFP WTILKYLIMP IYYHQRKRVT ELHNTSNNPE QEISLQELNE
     ETVVPTTKKT VTRDSATA