ID   DHSDA_DANRE             Reviewed;         154 AA.
AC   Q6DGM2;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Succinate dehydrogenase [ubiquinone] cytochrome b small subunit A, mitochondrial;
DE            Short=CybS-A;
DE   AltName: Full=Succinate dehydrogenase complex subunit D-A;
DE   AltName: Full=Succinate-ubiquinone oxidoreductase cytochrome b small subunit A;
DE   AltName: Full=Succinate-ubiquinone reductase membrane anchor subunit A;
DE   Flags: Precursor;
GN   Name=sdhda; Synonyms=sdhdb; ORFNames=zgc:92857;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH)
CC       that is involved in complex II of the mitochondrial electron transport
CC       chain and is responsible for transferring electrons from succinate to
CC       ubiquinone (coenzyme Q). {ECO:0000250}.
CC   -!- SUBUNIT: Component of complex II composed of four subunits: the
CC       flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome
CC       b560 composed of sdhc and sdhd. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CybS family. {ECO:0000305}.
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DR   EMBL; BC076319; AAH76319.1; -; mRNA.
DR   RefSeq; NP_001002489.1; NM_001002489.2.
DR   AlphaFoldDB; Q6DGM2; -.
DR   SMR; Q6DGM2; -.
DR   STRING; 7955.ENSDARP00000072578; -.
DR   PaxDb; Q6DGM2; -.
DR   Ensembl; ENSDART00000078115; ENSDARP00000072578; ENSDARG00000055712.
DR   GeneID; 436762; -.
DR   KEGG; dre:436762; -.
DR   CTD; 436762; -.
DR   ZFIN; ZDB-GENE-040718-192; sdhda.
DR   eggNOG; KOG4097; Eukaryota.
DR   GeneTree; ENSGT00390000010003; -.
DR   HOGENOM; CLU_096618_1_1_1; -.
DR   InParanoid; Q6DGM2; -.
DR   OMA; KAFEMIW; -.
DR   OrthoDB; 1511215at2759; -.
DR   PhylomeDB; Q6DGM2; -.
DR   TreeFam; TF313310; -.
DR   PRO; PR:Q6DGM2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000055712; Expressed in brain and 10 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005749; C:mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone); ISS:UniProtKB.
DR   GO; GO:0020037; F:heme binding; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048039; F:ubiquinone binding; ISS:UniProtKB.
DR   GO; GO:0006121; P:mitochondrial electron transport, succinate to ubiquinone; IBA:GO_Central.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR   CDD; cd03496; SQR_TypeC_CybS; 1.
DR   Gene3D; 1.20.1300.10; -; 1.
DR   InterPro; IPR007992; CybS.
DR   InterPro; IPR034804; SQR/QFR_C/D.
DR   PANTHER; PTHR13337; PTHR13337; 1.
PE   2: Evidence at transcript level;
KW   Electron transport; Heme; Iron; Membrane; Metal-binding; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport; Tricarboxylic acid cycle.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..154
FT                   /note="Succinate dehydrogenase [ubiquinone] cytochrome b
FT                   small subunit A, mitochondrial"
FT                   /id="PRO_0000343807"
FT   TOPO_DOM        ?..58
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        59..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        81..85
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        107..115
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        116..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        138..154
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   BINDING         97
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_note="ligand shared with sdhc"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250|UniProtKB:A5GZW8"
FT   BINDING         109
FT                   /ligand="a ubiquinone"
FT                   /ligand_id="ChEBI:CHEBI:16389"
FT                   /ligand_note="ligand shared with IP/sdhb"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   154 AA;  16729 MW;  7CFD6C507635114A CRC64;
     MASLIRLSSV WQRGMRPVLL CHTQLSRGSA CPRIGDVDYT EPAGRIHTAS SSTGISASQH
     WTGERVMTLV LLGMAPAAYL CPGPVVDYSI AAALTMHGHW GIGQVLTDYV HGEVKIKLAK
     VGIFLLSTAT FFGLCYFNYN DVGLCKAVVM LWQK