ID   DHSDA_XENLA             Reviewed;         152 AA.
AC   Q6AZR3;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Succinate dehydrogenase [ubiquinone] cytochrome b small subunit A, mitochondrial;
DE            Short=CybS-A;
DE   AltName: Full=Succinate dehydrogenase complex subunit D-A;
DE   AltName: Full=Succinate-ubiquinone oxidoreductase cytochrome b small subunit A;
DE   AltName: Full=Succinate-ubiquinone reductase membrane anchor subunit A;
DE   Flags: Precursor;
GN   Name=sdhd-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH)
CC       that is involved in complex II of the mitochondrial electron transport
CC       chain and is responsible for transferring electrons from succinate to
CC       ubiquinone (coenzyme Q). {ECO:0000250}.
CC   -!- SUBUNIT: Component of complex II composed of four subunits: the
CC       flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome
CC       b560 composed of sdhc and sdhd. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CybS family. {ECO:0000305}.
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DR   EMBL; BC077454; AAH77454.1; -; mRNA.
DR   RefSeq; NP_001087943.1; NM_001094474.1.
DR   RefSeq; XP_018082464.1; XM_018226975.1.
DR   AlphaFoldDB; Q6AZR3; -.
DR   SMR; Q6AZR3; -.
DR   DNASU; 494586; -.
DR   GeneID; 494586; -.
DR   KEGG; xla:494586; -.
DR   CTD; 494586; -.
DR   Xenbase; XB-GENE-6255924; sdhd.S.
DR   OMA; KAFEMIW; -.
DR   OrthoDB; 1511215at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 494586; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005749; C:mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone); ISS:UniProtKB.
DR   GO; GO:0020037; F:heme binding; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048039; F:ubiquinone binding; ISS:UniProtKB.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   CDD; cd03496; SQR_TypeC_CybS; 1.
DR   Gene3D; 1.20.1300.10; -; 1.
DR   InterPro; IPR007992; CybS.
DR   InterPro; IPR034804; SQR/QFR_C/D.
DR   PANTHER; PTHR13337; PTHR13337; 1.
DR   SUPFAM; SSF81343; SSF81343; 1.
PE   2: Evidence at transcript level;
KW   Electron transport; Heme; Iron; Membrane; Metal-binding; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport; Tricarboxylic acid cycle.
FT   TRANSIT         1..21
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..152
FT                   /note="Succinate dehydrogenase [ubiquinone] cytochrome b
FT                   small subunit A, mitochondrial"
FT                   /id="PRO_0000343808"
FT   TOPO_DOM        22..56
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        57..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        79..83
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        105..113
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        114..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        136..152
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   BINDING         95
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_note="ligand shared with sdhc"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250|UniProtKB:A5GZW8"
FT   BINDING         107
FT                   /ligand="a ubiquinone"
FT                   /ligand_id="ChEBI:CHEBI:16389"
FT                   /ligand_note="ligand shared with IP/sdhb"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   152 AA;  16345 MW;  EB802751979DD07C CRC64;
     MVTVLRLSSL CRANRASAFK SLLIRPVPCL SQDLHTVQTS QIHTSQNHHA ASKAASLHWT
     SERALSVALL GLLPAAYLYP GAAVDYSLAA ALTLHGHWGL GQVVTDYVHG DAKIKLANTS
     LFALSALTFA GLCYFNYHDV GICKAVAMLW SL