DHSD_CAEEL
ID DHSD_CAEEL Reviewed; 145 AA.
AC O62215;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Putative succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial;
DE Short=CybS;
DE AltName: Full=Succinate dehydrogenase complex subunit D;
DE AltName: Full=Succinate-ubiquinone reductase membrane anchor subunit;
DE Flags: Precursor;
GN Name=sdhd-1; ORFNames=F33A8.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP DISRUPTION PHENOTYPE.
RX PubMed=17998274; DOI=10.1093/toxsci/kfm278;
RA Zuryn S., Kuang J., Ebert P.;
RT "Mitochondrial modulation of phosphine toxicity and resistance in
RT Caenorhabditis elegans.";
RL Toxicol. Sci. 102:179-186(2008).
CC -!- FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH)
CC that is involved in complex II of the mitochondrial electron transport
CC chain and is responsible for transferring electrons from succinate to
CC ubiquinone (coenzyme Q). {ECO:0000250}.
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC -!- SUBUNIT: Forms part of complex II containing four subunits: a
CC flavoprotein (FP), an iron-sulfur protein (IP) and a cytochrome b
CC composed of a large and a small subunit. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Increased sensitivity to phosphine.
CC {ECO:0000269|PubMed:17998274}.
CC -!- SIMILARITY: Belongs to the CybS family. {ECO:0000305}.
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DR EMBL; Z81525; CAB04259.1; -; Genomic_DNA.
DR PIR; T21691; T21691.
DR RefSeq; NP_496369.1; NM_063968.5.
DR AlphaFoldDB; O62215; -.
DR SMR; O62215; -.
DR BioGRID; 40002; 1.
DR IntAct; O62215; 1.
DR STRING; 6239.F33A8.5.1; -.
DR EPD; O62215; -.
DR PaxDb; O62215; -.
DR PeptideAtlas; O62215; -.
DR EnsemblMetazoa; F33A8.5.1; F33A8.5.1; WBGene00009353.
DR GeneID; 174692; -.
DR KEGG; cel:CELE_F33A8.5; -.
DR CTD; 174692; -.
DR WormBase; F33A8.5; CE17757; WBGene00009353; sdhd-1.
DR eggNOG; KOG4097; Eukaryota.
DR GeneTree; ENSGT00390000010003; -.
DR HOGENOM; CLU_096618_1_1_1; -.
DR InParanoid; O62215; -.
DR OMA; KLERLWA; -.
DR OrthoDB; 1511215at2759; -.
DR PhylomeDB; O62215; -.
DR Reactome; R-CEL-71403; Citric acid cycle (TCA cycle).
DR UniPathway; UPA00223; -.
DR PRO; PR:O62215; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00009353; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005749; C:mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone); ISS:UniProtKB.
DR GO; GO:0020037; F:heme binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048039; F:ubiquinone binding; ISS:UniProtKB.
DR GO; GO:0006121; P:mitochondrial electron transport, succinate to ubiquinone; IBA:GO_Central.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR CDD; cd03496; SQR_TypeC_CybS; 1.
DR Gene3D; 1.20.1300.10; -; 1.
DR InterPro; IPR007992; CybS.
DR InterPro; IPR034804; SQR/QFR_C/D.
DR PANTHER; PTHR13337; PTHR13337; 1.
PE 3: Inferred from homology;
KW Electron transport; Heme; Iron; Membrane; Metal-binding; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix; Transport; Tricarboxylic acid cycle.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..145
FT /note="Putative succinate dehydrogenase [ubiquinone]
FT cytochrome b small subunit, mitochondrial"
FT /id="PRO_0000006491"
FT TOPO_DOM 1..45
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..74
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..108
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..145
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT BINDING 84
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_note="ligand shared with large subunit"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
FT BINDING 96
FT /ligand="a ubiquinone"
FT /ligand_id="ChEBI:CHEBI:16389"
FT /ligand_note="ligand shared with IP"
FT /evidence="ECO:0000250"
SQ SEQUENCE 145 AA; 15765 MW; 7DC2E328DC9AFB42 CRC64;
MAASLRHMAH FQKALLVARS APRISTIVRA TSTLNDGASK VPDHSMHFKL ERLWAVGMLP
ILPASYFIHG PVMDAVLTVA LTLHIHWGIH GVVYDYARPY VIGEAAAKAA HVGVYLITGL
LLGALLHFNT NDVGITKAFE LVFSL
