DHSD_PORPU
ID DHSD_PORPU Reviewed; 95 AA.
AC P80479;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Succinate dehydrogenase membrane anchor subunit;
DE AltName: Full=Succinate dehydrogenase, subunit IV;
GN Name=SDH4; Synonyms=SDHD;
OS Porphyra purpurea (Red seaweed) (Ulva purpurea).
OG Mitochondrion.
OC Eukaryota; Rhodophyta; Bangiophyceae; Bangiales; Bangiaceae; Porphyra.
OX NCBI_TaxID=2787;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8637872; DOI=10.1073/pnas.93.6.2328;
RA Burger G., Lang B.F., Reith M., Gray M.W.;
RT "Genes encoding the same three subunits of respiratory complex II are
RT present in the mitochondrial DNA of two phylogenetically distant
RT eukaryotes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:2328-2332(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Burger G., Saint-Louis D., Gray M.W., Lang B.F.;
RT "Complete sequence of the mitochondrial DNA of the red alga, Porphyra
RT purpurea. Inverted repeats, sequence polymorphisms, and cyanobacterial
RT introns.";
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
CC {ECO:0000250}.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC Note=The heme is bound between the two transmembrane subunits.
CC {ECO:0000250};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC -!- SUBUNIT: Part of an enzyme complex containing four subunits: a
CC flavoprotein, an iron-sulfur protein, plus two membrane-anchoring
CC proteins. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
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DR EMBL; AF114794; AAD03108.1; -; Genomic_DNA.
DR PIR; T11229; T11229.
DR RefSeq; NP_049305.1; NC_002007.1.
DR AlphaFoldDB; P80479; -.
DR SMR; P80479; -.
DR GeneID; 809777; -.
DR UniPathway; UPA00223; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.20.1300.10; -; 1.
DR InterPro; IPR034804; SQR/QFR_C/D.
DR SUPFAM; SSF81343; SSF81343; 1.
PE 3: Inferred from homology;
KW Electron transport; Heme; Iron; Membrane; Metal-binding; Mitochondrion;
KW Mitochondrion inner membrane; Transmembrane; Transmembrane helix;
KW Transport; Tricarboxylic acid cycle.
FT CHAIN 1..95
FT /note="Succinate dehydrogenase membrane anchor subunit"
FT /id="PRO_0000158712"
FT TOPO_DOM 1..19
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..74
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT BINDING 53
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_note="ligand shared with second transmembrane
FT subunit"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
FT BINDING 65
FT /ligand="a ubiquinone"
FT /ligand_id="ChEBI:CHEBI:16389"
FT /evidence="ECO:0000250"
SQ SEQUENCE 95 AA; 11265 MW; 53C1A9F97BE07391 CRC64;
MYKTLLAQVF FHSIAKKKLY FFWLPRLFSL LLVPGFLFDI EILFLFHPII LLHASLGLSV
IIEDYIHIET IKFQYLSLIK LLLVLLINLN ILYLL
