ID   DHX15_STRPU             Reviewed;         455 AA.
AC   O17438;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1;
DE            EC=3.6.4.13;
DE   Flags: Fragment;
GN   Name=PRP1;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RA   Moy G.M., Schulz J.R., Vacquier V.D.;
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Pre-mRNA processing factor involved in disassembly of
CC       spliceosomes after the release of mature mRNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       DDX15/PRP43 sub-subfamily. {ECO:0000305}.
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DR   EMBL; AF028244; AAB86472.1; -; mRNA.
DR   AlphaFoldDB; O17438; -.
DR   SMR; O17438; -.
DR   STRING; 7668.SPU_010853-tr; -.
DR   eggNOG; KOG0925; Eukaryota.
DR   HOGENOM; CLU_001832_5_11_1; -.
DR   InParanoid; O17438; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Helicase; Hydrolase; mRNA processing; mRNA splicing;
KW   Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           <1..>455
FT                   /note="Putative pre-mRNA-splicing factor ATP-dependent RNA
FT                   helicase PRP1"
FT                   /id="PRO_0000055143"
FT   DOMAIN          <1..81
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          106..286
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           28..31
FT                   /note="DEAH box"
FT   NON_TER         1
FT   NON_TER         455
SQ   SEQUENCE   455 AA;  51479 MW;  D06149A7EB4C64FB CRC64;
     IKYMTDGMLL REGMTDPLLE RYGVILLDEA HERTVATDIL MGLLKEVEKQ RSDLKLVVMS
     ATLDAGKFQH YFDNAPLMTV PGRTHPVEIF YTPEPERDYL EAAIRTVVQI HMCEEVEGDV
     LLFLTGQEEI EEACKRIKRE VDNLGPEVGD LKTIPLYSTL PPAMQQRIFE HAPPNKANGA
     IGRKVVVSTN IAETSLTIDG VVFVIDPGFA KQKVYNPRIR VESLLVSPIS KASAQQRVGR
     AGRTRPGKCF RLYTEKAYDS EMQDNTYPEI LRSNLGTVVL QLKKLGIDDL VHFDFMDPPA
     PETLMRALEL LNYLGALDDS GDLTRLGSMM AEFPLDPQLA KMVIASTDYS CSNEILSVTA
     MLSVPQCFLR PNEAKKLADE AKMRFAHIDG DHLTLLNVYH AFKQNNEDPQ WCYDNFIQYR
     SLKSADSVRQ QLARIMDRFA LQRTSTNFNS KDYYL