DHX32_HUMAN
ID DHX32_HUMAN Reviewed; 743 AA.
AC Q7L7V1; A8MSV2; D3DRF9; Q49AG5; Q5T3L0; Q5T3L5; Q96NY1; Q9BUN0; Q9H769;
AC Q9NSL5; Q9NV74; Q9NVJ7;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32;
DE EC=3.6.4.13;
DE AltName: Full=DEAD/H box 32;
DE AltName: Full=DEAD/H helicase-like protein 1;
DE Short=DHLP1;
DE AltName: Full=DEAH box protein 32;
DE AltName: Full=HuDDX32;
GN Name=DHX32; Synonyms=DDX32;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF
RP 230-414 (ISOFORM 2), INDUCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Myeloid leukemia cell;
RX PubMed=12163057; DOI=10.1016/s0145-2126(02)00040-1;
RA Abdelhaleem M.;
RT "The novel helicase homologue DDX32 is down-regulated in acute
RT lymphoblastic leukemia.";
RL Leuk. Res. 26:945-954(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RX PubMed=12527204; DOI=10.1016/s0378-1119(02)01098-3;
RA Meng X., Liu J., Shen Z.;
RT "Genomic structure of the human BCCIP gene and its expression in cancer.";
RL Gene 302:139-146(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, Kidney, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 238-743 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [8]
RP INDUCTION.
RX PubMed=16414036; DOI=10.1016/j.cellimm.2005.12.003;
RA Alli Z., Nam E.H., Beimnet K., Abdelhaleem M.;
RT "The activation-induced expression of DHX32 in Jurkat T cells is specific
RT and involves calcium and nuclear factor of activated T cells.";
RL Cell. Immunol. 237:141-146(2005).
RN [9]
RP TISSUE SPECIFICITY.
RX PubMed=16181624; DOI=10.1016/j.yexmp.2005.07.002;
RA Alli Z., Ho M., Abdelhaleem M.;
RT "Expression of DHX32 in lymphoid tissues.";
RL Exp. Mol. Pathol. 79:219-223(2005).
RN [10]
RP SUBCELLULAR LOCATION.
RX PubMed=16959245; DOI=10.1016/j.yexmp.2006.07.005;
RA Alli Z., Ackerley C., Chen Y., Al-Saud B., Abdelhaleem M.;
RT "Nuclear and mitochondrial localization of the putative RNA helicase
RT DHX32.";
RL Exp. Mol. Pathol. 81:245-248(2006).
RN [11]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [12]
RP VARIANT [LARGE SCALE ANALYSIS] ARG-209.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC -!- INTERACTION:
CC Q7L7V1; Q3B820: FAM161A; NbExp=9; IntAct=EBI-2807297, EBI-719941;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16959245}.
CC Mitochondrion {ECO:0000269|PubMed:16959245}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7L7V1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7L7V1-2; Sequence=VSP_026427;
CC -!- TISSUE SPECIFICITY: Expressed in lymphoid tissues (at protein level).
CC Expressed in brain, heart, skeletal muscle, colon, thymus, spleen,
CC kidney, liver, small intestine, placenta, lung, lymphoid tissues and
CC blood leukocytes. {ECO:0000269|PubMed:12163057,
CC ECO:0000269|PubMed:16181624}.
CC -!- INDUCTION: Up-regulated by ionomycin in T-lymphocytes. Down-regulated
CC in acute lymphoblastic leukemia. {ECO:0000269|PubMed:12163057,
CC ECO:0000269|PubMed:16414036}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH37925.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB15029.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF427340; AAL26550.1; -; mRNA.
DR EMBL; AF427341; AAL26551.1; -; mRNA.
DR EMBL; AY064247; AAL55437.1; -; Genomic_DNA.
DR EMBL; AY064250; AAL55441.1; -; mRNA.
DR EMBL; AK001556; BAA91754.1; -; mRNA.
DR EMBL; AK001751; BAA91882.1; -; mRNA.
DR EMBL; AK024869; BAB15029.1; ALT_INIT; mRNA.
DR EMBL; AL360176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471066; EAW49216.1; -; Genomic_DNA.
DR EMBL; CH471066; EAW49217.1; -; Genomic_DNA.
DR EMBL; BC002473; AAH02473.3; -; mRNA.
DR EMBL; BC037925; AAH37925.1; ALT_FRAME; mRNA.
DR EMBL; BC068471; AAH68471.1; -; mRNA.
DR EMBL; AL162051; CAB82394.1; -; mRNA.
DR CCDS; CCDS7652.1; -. [Q7L7V1-1]
DR PIR; T47184; T47184.
DR RefSeq; NP_060650.2; NM_018180.2. [Q7L7V1-1]
DR RefSeq; XP_016871893.1; XM_017016404.1.
DR RefSeq; XP_016871894.1; XM_017016405.1.
DR AlphaFoldDB; Q7L7V1; -.
DR SMR; Q7L7V1; -.
DR BioGRID; 120878; 50.
DR IntAct; Q7L7V1; 13.
DR MINT; Q7L7V1; -.
DR STRING; 9606.ENSP00000284690; -.
DR iPTMnet; Q7L7V1; -.
DR PhosphoSitePlus; Q7L7V1; -.
DR BioMuta; DHX32; -.
DR DMDM; 74759011; -.
DR EPD; Q7L7V1; -.
DR jPOST; Q7L7V1; -.
DR MassIVE; Q7L7V1; -.
DR MaxQB; Q7L7V1; -.
DR PaxDb; Q7L7V1; -.
DR PeptideAtlas; Q7L7V1; -.
DR PRIDE; Q7L7V1; -.
DR ProteomicsDB; 68827; -. [Q7L7V1-1]
DR ProteomicsDB; 68828; -. [Q7L7V1-2]
DR Antibodypedia; 32435; 164 antibodies from 23 providers.
DR DNASU; 55760; -.
DR Ensembl; ENST00000284690.4; ENSP00000284690.3; ENSG00000089876.12. [Q7L7V1-1]
DR GeneID; 55760; -.
DR KEGG; hsa:55760; -.
DR MANE-Select; ENST00000284690.4; ENSP00000284690.3; NM_018180.3; NP_060650.2.
DR UCSC; uc001ljf.1; human. [Q7L7V1-1]
DR CTD; 55760; -.
DR DisGeNET; 55760; -.
DR GeneCards; DHX32; -.
DR HGNC; HGNC:16717; DHX32.
DR HPA; ENSG00000089876; Low tissue specificity.
DR MIM; 607960; gene.
DR neXtProt; NX_Q7L7V1; -.
DR OpenTargets; ENSG00000089876; -.
DR PharmGKB; PA27219; -.
DR VEuPathDB; HostDB:ENSG00000089876; -.
DR eggNOG; KOG0925; Eukaryota.
DR GeneTree; ENSGT00940000157227; -.
DR HOGENOM; CLU_001832_5_11_1; -.
DR InParanoid; Q7L7V1; -.
DR OMA; NKEQKMC; -.
DR OrthoDB; 354219at2759; -.
DR PhylomeDB; Q7L7V1; -.
DR TreeFam; TF105735; -.
DR PathwayCommons; Q7L7V1; -.
DR SignaLink; Q7L7V1; -.
DR BioGRID-ORCS; 55760; 5 hits in 1084 CRISPR screens.
DR ChiTaRS; DHX32; human.
DR GeneWiki; DHX32; -.
DR GenomeRNAi; 55760; -.
DR Pharos; Q7L7V1; Tbio.
DR PRO; PR:Q7L7V1; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q7L7V1; protein.
DR Bgee; ENSG00000089876; Expressed in nasal cavity epithelium and 208 other tissues.
DR ExpressionAtlas; Q7L7V1; baseline and differential.
DR Genevisible; Q7L7V1; HS.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF04408; HA2; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00847; HA2; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; ATP-binding; Helicase; Hydrolase;
KW Mitochondrion; Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..743
FT /note="Putative pre-mRNA-splicing factor ATP-dependent RNA
FT helicase DHX32"
FT /id="PRO_0000292663"
FT DOMAIN 72..238
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 185..188
FT /note="DEAH box"
FT BINDING 85..92
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT VAR_SEQ 284..364
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12163057"
FT /id="VSP_026427"
FT VARIANT 209
FT /note="P -> R (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035843"
FT VARIANT 271
FT /note="E -> D (in dbSNP:rs11244674)"
FT /id="VAR_052181"
FT VARIANT 301
FT /note="D -> A (in dbSNP:rs35772239)"
FT /id="VAR_052182"
FT VARIANT 430
FT /note="V -> L (in dbSNP:rs17153669)"
FT /id="VAR_052183"
FT CONFLICT 26
FT /note="D -> G (in Ref. 3; BAA91754)"
FT /evidence="ECO:0000305"
FT CONFLICT 123
FT /note="V -> M (in Ref. 3; BAA91882)"
FT /evidence="ECO:0000305"
FT CONFLICT 171
FT /note="M -> V (in Ref. 3; BAA91754)"
FT /evidence="ECO:0000305"
FT CONFLICT 231
FT /note="N -> F (in Ref. 1; AAL26551)"
FT /evidence="ECO:0000305"
FT CONFLICT 459
FT /note="L -> S (in Ref. 3; BAA91882)"
FT /evidence="ECO:0000305"
FT CONFLICT 496
FT /note="A -> G (in Ref. 3; BAA91882)"
FT /evidence="ECO:0000305"
FT CONFLICT 499
FT /note="E -> G (in Ref. 6; AAH37925)"
FT /evidence="ECO:0000305"
FT CONFLICT 567
FT /note="V -> A (in Ref. 3; BAB15029)"
FT /evidence="ECO:0000305"
FT CONFLICT 590
FT /note="E -> G (in Ref. 6; AAH37925)"
FT /evidence="ECO:0000305"
FT CONFLICT 686
FT /note="P -> L (in Ref. 3; BAA91882)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 743 AA; 84419 MW; D6D5C570561C468A CRC64;
MEEEGLECPN SSSEKRYFPE SLDSSDGDEE EVLACEDLEL NPFDGLPYSS RYYKLLKERE
DLPIWKEKYS FMENLLQNQI VIVSGDAKCG KSAQVPQWCA EYCLSIHYQH GGVICTQVHK
QTVVQLALRV ADEMDVNIGH EVGYVIPFEN CCTNETILRY CTDDMLQREM MSNPFLGSYG
VIILDDIHER SIATDVLLGL LKDVLLARPE LKLIINSSPH LISKLNSYYG NVPVIEVKNK
HPVEVVYLSE AQKDSFESIL RLIFEIHHSG EKGDIVVFLA CEQDIEKVCE TVYQGSNLNP
DLGELVVVPL YPKEKCSLFK PLDETEKRCQ VYQRRVVLTT SSGEFLIWSN SVRFVIDVGV
ERRKVYNPRI RANSLVMQPI SQSQAEIRKQ ILGSSSSGKF FCLYTEEFAS KDMTPLKPAE
MQEANLTSMV LFMKRIDIAG LGHCDFMNRP APESLMQALE DLDYLAALDN DGNLSEFGII
MSEFPLDPQL SKSILASCEF DCVDEVLTIA AMVTAPNCFS HVPHGAEEAA LTCWKTFLHP
EGDHFTLISI YKAYQDTTLN SSSEYCVEKW CRDYFLNCSA LRMADVIRAE LLEIIKRIEL
PYAEPAFGSK ENTLNIKKAL LSGYFMQIAR DVDGSGNYLM LTHKQVAQLH PLSGYSITKK
MPEWVLFHKF SISENNYIRI TSEISPELFM QLVPQYYFSN LPPSESKDIL QQVVDHLSPV
STMNKEQQMC ETCPETEQRC TLQ
