ID   DHX40_RAT               Reviewed;         779 AA.
AC   Q5XI69;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Probable ATP-dependent RNA helicase DHX40;
DE            EC=3.6.4.13;
DE   AltName: Full=DEAH box protein 40;
GN   Name=Dhx40;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probable ATP-dependent RNA helicase. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC083821; AAH83821.1; -; mRNA.
DR   RefSeq; NP_001005873.1; NM_001005873.1.
DR   AlphaFoldDB; Q5XI69; -.
DR   SMR; Q5XI69; -.
DR   STRING; 10116.ENSRNOP00000006926; -.
DR   PhosphoSitePlus; Q5XI69; -.
DR   jPOST; Q5XI69; -.
DR   PaxDb; Q5XI69; -.
DR   PRIDE; Q5XI69; -.
DR   GeneID; 287595; -.
DR   KEGG; rno:287595; -.
DR   CTD; 79665; -.
DR   RGD; 1359618; Dhx40.
DR   VEuPathDB; HostDB:ENSRNOG00000004549; -.
DR   eggNOG; KOG0922; Eukaryota.
DR   InParanoid; Q5XI69; -.
DR   OMA; RRKWTNK; -.
DR   OrthoDB; 354219at2759; -.
DR   PhylomeDB; Q5XI69; -.
DR   TreeFam; TF332290; -.
DR   PRO; PR:Q5XI69; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000004549; Expressed in testis and 20 other tissues.
DR   Genevisible; Q5XI69; RN.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..779
FT                   /note="Probable ATP-dependent RNA helicase DHX40"
FT                   /id="PRO_0000252398"
FT   DOMAIN          63..231
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          263..442
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           173..176
FT                   /note="DEAH box"
FT   COMPBIAS        10..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         76..83
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   779 AA;  88514 MW;  79F3303D748916BB CRC64;
     MSRFPAVAGR APRRQEEGER PVELQEERPS AVRIADREEK GCTSQEGGTT PTFPIQKQRK
     KLIQAVRDNS FLIVTGNTGS GKTTQLPKYL YEAGFSQHGM IGVTQPRKVA AISVAQRVAE
     EMKCTLGSKV GYQVRFDDCS SKETAIKYMT DGCLLKHILG DPNLNKFSVI ILDEAHERTL
     TTDILFGLLK KLFQDKSPNR KEHLKVVVMS ATMELAKLSA FFGNCPIFDI PGRLYPVREK
     FCNLIGPRDR ENTAYIQAIV KVTMDIHLNE MAGDILVFLT GQFEIEKSCE LLFQMAESVD
     YDYDVQDTTL DGLLILPCYG SMTTDQQRRI FLPPPPGIRK CVISTNISAT SLTIDGIRYV
     VDGGFVKQLN HNPRLGLDIL EVVPISKSEA LQRSGRAGRT ASGKCFRIYS KDFWNQCMPD
     HVIPEIKRTS LTSVVLTLKC LAIHDVIRFP YLDPPNERLI LEALKQLYQC DAIDRSGHVT
     RLGLSMVEFP LPPHLTCAVI RAASLDCEDL LLPIAAMLSV ENVFIRPVDP EYQKEAEQKH
     RELAAKAGGF NDFATLAVIF EQCKSSGAPA SWCQKHWIHW RCLFSAFRVE AQLRELIRKL
     KQQSDFPRET FEGPKHEVLR RCLCAGYFKN VARRSVGRTF CTMDGRGSPV HIHPSSALHE
     QETKLEWIIF HEVLVTTKVY ARIVCPIRYE WVRDLLPKLH ELNAHDLSSV ARREMRDDAR
     RKWTNKENVK QLKDGISKEV LKKMQRRNDD KSISDARARF LERKQQRIQD HSDTLKETG