DI2BA_DANRE
ID DI2BA_DANRE Reviewed; 1577 AA.
AC Q6NVJ5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Disco-interacting protein 2 homolog B-A;
DE Short=DIP2 homolog B-A;
GN Name=dip2ba; Synonyms=dip2b; ORFNames=zgc:77348;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negatively regulates axonal outgrowth and is essential for
CC normal synaptic transmission. Not required for regulation of axon
CC polarity. Promotes acetylation of alpha-tubulin.
CC {ECO:0000250|UniProtKB:Q3UH60}.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000250|UniProtKB:Q3UH60}. Cell projection, axon
CC {ECO:0000250|UniProtKB:Q3UH60}. Perikaryon
CC {ECO:0000250|UniProtKB:Q3UH60}.
CC -!- SIMILARITY: Belongs to the DIP2 family. {ECO:0000305}.
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DR EMBL; BC068015; AAH68015.1; -; mRNA.
DR RefSeq; NP_998128.1; NM_212963.1.
DR AlphaFoldDB; Q6NVJ5; -.
DR SMR; Q6NVJ5; -.
DR STRING; 7955.ENSDARP00000019936; -.
DR PaxDb; Q6NVJ5; -.
DR Ensembl; ENSDART00000019521; ENSDARP00000019936; ENSDARG00000005350.
DR GeneID; 405899; -.
DR KEGG; dre:405899; -.
DR CTD; 405899; -.
DR ZFIN; ZDB-GENE-040426-2305; dip2ba.
DR eggNOG; KOG3628; Eukaryota.
DR GeneTree; ENSGT00950000182997; -.
DR HOGENOM; CLU_001345_0_0_1; -.
DR InParanoid; Q6NVJ5; -.
DR OMA; VPVCTAT; -.
DR OrthoDB; 539697at2759; -.
DR PhylomeDB; Q6NVJ5; -.
DR TreeFam; TF312871; -.
DR PRO; PR:Q6NVJ5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 23.
DR Bgee; ENSDARG00000005350; Expressed in heart and 26 other tissues.
DR GO; GO:0030424; C:axon; ISS:UniProtKB.
DR GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR GO; GO:0043204; C:perikaryon; ISS:UniProtKB.
DR GO; GO:0030517; P:negative regulation of axon extension; ISS:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:2000758; P:positive regulation of peptidyl-lysine acetylation; ISS:UniProtKB.
DR CDD; cd05905; Dip2; 2.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.12780; -; 2.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR037337; Dip2-like_dom.
DR InterPro; IPR010506; DMAP1-bd.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF06464; DMAP_binding; 1.
DR SMART; SM01137; DMAP_binding; 1.
DR PROSITE; PS51912; DMAP1_BIND; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Neurogenesis; Reference proteome.
FT CHAIN 1..1577
FT /note="Disco-interacting protein 2 homolog B-A"
FT /id="PRO_0000318738"
FT DOMAIN 7..124
FT /note="DMAP1-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01260"
FT REGION 109..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1577 AA; 171678 MW; 2A4B29F19ED80B58 CRC64;
MADRGVDLAA LPKEVREQLA ELELELSEGD ITQKGYEKKR AKLLAPFVPQ TQNVDVSILS
TDSTSSPITI PIAAPRQHRA HRSGGTRDDR YRSDIHTEAV QAALARHKEE KMALPMPTKR
RSAFVQSPAE NCTPPDTSSA SEDEGSLRRR QAAISAMLAQ NLQSPEYWIN RSVQGSSTSS
SASSTLSHGD GKTHNHNNHS QGQTSALADV LAHTRIDTNS SSGSVPPDVT STAPQDRNSR
VDLPANIAVK GISRGQSRSS MMDTAGGVPA HSRVSTKIQQ LLNTLKRPKR PPLSEFFLDD
SEEIVEVPQP DPNTPRPEGR QIIPVKGEPL GVVSNWPPAL QAALARWGAT QAKSPALTAL
DITGKPLYTL TYGKLWSRSL KLAYTLLNKL GTKNEPVLKP GDRVALVYPN SDPGMFWVAF
YGCLLAEVIP VPIEVPLSRK DAGSQQIGFL LGSCGVGLAL TSEVCLKGLP KTPNGEIMQF
KGWPRLKWVV TDTKYLTKPS KDWQPHIPTA NTDTAYIEYK ASKEGTVMGV AVSKISMLTH
CQALTQACNY CEGETLVNVL DFKKDSGLWH GVLTSVMNRI HTISVPYAVM KACPLSWVQR
VHVHKARVAL VKCRDLHWAM MAHRDQKDTN LSSLRMLIVA DGANPWSVSS CDAFLNVFQS
HGLKPEMICP CASSPEAMTV AIRRPGAPGT PLPARAILSM AGLSHGVIRV NTEDKNSALT
VQDVGHVMPG ALMCIVKPDG PPMLCKTDEI GEIVLNSRAG GTMYYGLPGV TKNTFEVIPV
NSGGTPIGDV PFTRTGLLGF VGPGSLVFVV GKIEGLLSVS GRRHNADDLV ATALAVEPVK
TVYRGRIAVF SVTVFYDERV VIVAEQRPDA NEEDSFQWMS RVLQAIDSIH QVGLYCLALV
PANTLPKTPL GGIHVSETKH HFLEGSLHPC NILMCPHTCV TNLPKPRQKQ PVGVGPASIM
VGNLVAGKRI AQASGRDLGL IDDQEQSRKH QFLSEALQWR AQTDPDHVLY MLLNAKGVAV
STATCSQLHK RAEKITAALL ERGGINTGDN VVLLYPPGID LIASFYGCLY AGCIPVTVRP
PHPQNLSATL PTVRMIIDVS KAACILTTQT LMKTLRSKEA AASVNVKTWP NIIDTDDLPR
KRPASIYKPP TAEMLAYLDF SVSTTGMLTG VKMSHSAVNA LCRSIKLQCE LYSSRQIAIC
MDPYCGLGFV LWCLSSVYSG HQSILIPPME LETSLPLWLS TLSQYKIRDT FCSYSVMELC
TKGLGTQTEA LKARNVNLSC VRSCVVIAEE RPRLALTQSF SKLFKDLGLS PRAVSTAFGS
RVNLAICLQG TAGPDPSTVY VDMKSLRHDR VRLVERGAPQ SLPLMESGTM LPGVRVIIVN
PETKGPLGDS HLGEIWVNSP HNASGYYTIY GEESLQADHF NTRLSFGDTE TLWARTGYLG
FVKRTELLDA SGDRHDALFV VGSLDETLEL RGLRYHPIDI ETSVSRAHRS IAESAVFTWT
NLLVVVVELS GSEQEALDLV PLVTNVVLKE HHLIVGVVVI VDPGVIPINS RGEKQRMHLR
DSFLADQLDP IYVAYNM
