ID   DI3L1_DANRE             Reviewed;        1057 AA.
AC   A2RV18;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=DIS3-like exonuclease 1;
DE            EC=3.1.13.-;
GN   Name=dis3l; ORFNames=zgc:158615;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative cytoplasm-specific catalytic component of the RNA
CC       exosome complex which has 3'->5' exoribonuclease activity and
CC       participates in a multitude of cellular RNA processing and degradation
CC       events. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SUBUNIT: Component of the RNA exosome complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family. {ECO:0000305}.
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DR   EMBL; BC133136; AAI33137.1; -; mRNA.
DR   RefSeq; NP_001103928.1; NM_001110458.1.
DR   AlphaFoldDB; A2RV18; -.
DR   SMR; A2RV18; -.
DR   STRING; 7955.ENSDARP00000069661; -.
DR   PaxDb; A2RV18; -.
DR   PeptideAtlas; A2RV18; -.
DR   GeneID; 560362; -.
DR   KEGG; dre:560362; -.
DR   CTD; 115752; -.
DR   ZFIN; ZDB-GENE-070209-95; dis3l.
DR   eggNOG; KOG2102; Eukaryota.
DR   InParanoid; A2RV18; -.
DR   OrthoDB; 1104619at2759; -.
DR   PhylomeDB; A2RV18; -.
DR   PRO; PR:A2RV18; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0000177; C:cytoplasmic exosome (RNase complex); ISS:UniProtKB.
DR   GO; GO:0000178; C:exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016075; P:rRNA catabolic process; IBA:GO_Central.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR041505; Dis3_CSD2.
DR   InterPro; IPR031192; DIS3L.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR033771; Rrp44_CSD1.
DR   InterPro; IPR033770; RRP44_S1.
DR   PANTHER; PTHR23355:SF30; PTHR23355:SF30; 1.
DR   Pfam; PF17849; OB_Dis3; 1.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF17216; Rrp44_CSD1; 1.
DR   Pfam; PF17215; Rrp44_S1; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; SSF50249; 3.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Exonuclease; Exosome; Hydrolase; Magnesium; Nuclease;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..1057
FT                   /note="DIS3-like exonuclease 1"
FT                   /id="PRO_0000314814"
FT   REGION          998..1017
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1057 AA;  120352 MW;  61E7CA1C068E3C57 CRC64;
     MIKTEKILHL NSSKGRKVRV VREHYMREQV PCGSSLCQAD CQNVGKVLSR DVTHYVVPDV
     GVVRDFLEIL ELRELQGIVL TQTAYQTVQH TRGRRHYNRL RSLLKDPRHD CVLFANEFQQ
     YSYCPREKGE SQDKWHTRNV YNAAVWYYNH LAGLQPVVMI TEDRDAISEF SASNSGVFVI
     STQEYLLGFW PDLQAAHDLY HSIAQTLQER ENDGAEKVYT EHLPAEVLEA GIKSGRYIQG
     ILSVNKHRAQ HEAFVRYEGS ASKNTELNSD VLINGAKHRN RAVHGDVVVI ELLPRNEWKG
     RTMALTEGQG EERPLEDTQS QPMPTGRVVE ILQRNWRDYV VTLPPFEEMQ SQSRNSQKIL
     VVPWDYRIPK IRISTQQAEA LQDQRVIVRL DSWESTSVYP NGHFVRVLGK SGELETEIQT
     ILVENCIHVP PFSEAQLREM PVNTEENPWQ MDSNEVSSRR DLRDSHLVFS IDPKGCEDVD
     DTLSVRTLPG GKRLELGVHI ADVTHFVREG SLTDLEARSR ATTYYLADRR YDMLPAVLSA
     DLCSLLGGVD RYAMSVLWEL DAETLEVCSV WFGRTLIRSS YQLHYELAQS LLNGEEVEVP
     ELNPLKGSQR DQKMSELLQA LETLTRVARH LRAQRDKGGA LELEGVEVRA QLDEEKNITA
     LVPKQPLEVH ETVAECMIYA NHWVARKIQE SFPHHALLRH HPPPKQEFFN HLIDSAKAHG
     FSIDTRSNRA LADSLERAVD PRDPLVNRLL RMMATQAMSN ALYFSTGSCP EEQYYHYGLA
     LARYTHFTSP IRRYADVIVH RLLMAAVQLE KDESPSKALA CNKELEELAQ HINNKNRAAQ
     HSQKQSIELF QCMYFRDKDS HTDERCVADA VIYAVRANGF LAFVPQYGLK GAVYLKDREG
     QVISVDGDGK CEWKPGTLQK YSDKIITSTS TGTHTFYLFN HVTVRISVEP SRCHADSLNL
     ELISNKPHCA VQPESQPAGG GRSGLVEEVV RWAEEASLQA EEQRGRKPKL SKEEKQFRQS
     KTPNLYVLLQ EISELALMDL SICQITNSEE QTCTVSS