ID   DI3L1_RAT               Reviewed;        1054 AA.
AC   Q5U2P0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DIS3-like exonuclease 1;
DE            EC=3.1.13.-;
GN   Name=Dis3l;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Putative cytoplasm-specific catalytic component of the RNA
CC       exosome complex which has 3'->5' exoribonuclease activity and
CC       participates in a multitude of cellular RNA processing and degradation
CC       events. In the cytoplasm, the RNA exosome complex is involved in
CC       general mRNA turnover and specifically degrades inherently unstable
CC       mRNAs containing AU-rich elements (AREs) within their 3' untranslated
CC       regions, and in RNA surveillance pathways, preventing translation of
CC       aberrant mRNAs. It seems to be involved in degradation of histone mRNA.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SUBUNIT: Component of the RNA exosome complex. The catalytically
CC       inactive RNA exosome core (Exo-9) complex is believed to associate with
CC       catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and
CC       nuclear-specific RNA exosome complex forms (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH85932.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC085932; AAH85932.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001008381.1; NM_001008380.1.
DR   RefSeq; XP_006243323.1; XM_006243261.2.
DR   RefSeq; XP_006243324.1; XM_006243262.3.
DR   RefSeq; XP_006243325.1; XM_006243263.3.
DR   AlphaFoldDB; Q5U2P0; -.
DR   SMR; Q5U2P0; -.
DR   STRING; 10116.ENSRNOP00000014071; -.
DR   jPOST; Q5U2P0; -.
DR   PaxDb; Q5U2P0; -.
DR   PRIDE; Q5U2P0; -.
DR   Ensembl; ENSRNOT00000014071; ENSRNOP00000014071; ENSRNOG00000010537.
DR   GeneID; 363077; -.
DR   KEGG; rno:363077; -.
DR   UCSC; RGD:1308959; rat.
DR   CTD; 115752; -.
DR   RGD; 1308959; Dis3l.
DR   eggNOG; KOG2102; Eukaryota.
DR   GeneTree; ENSGT00530000063106; -.
DR   HOGENOM; CLU_002333_5_0_1; -.
DR   InParanoid; Q5U2P0; -.
DR   OMA; WKVNPEE; -.
DR   OrthoDB; 1104619at2759; -.
DR   PhylomeDB; Q5U2P0; -.
DR   TreeFam; TF105755; -.
DR   PRO; PR:Q5U2P0; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000010537; Expressed in testis and 20 other tissues.
DR   Genevisible; Q5U2P0; RN.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0000177; C:cytoplasmic exosome (RNase complex); ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0000178; C:exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; ISS:UniProtKB.
DR   GO; GO:0019899; F:enzyme binding; ISO:RGD.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006401; P:RNA catabolic process; ISO:RGD.
DR   GO; GO:0006396; P:RNA processing; ISO:RGD.
DR   GO; GO:0016075; P:rRNA catabolic process; ISO:RGD.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR041505; Dis3_CSD2.
DR   InterPro; IPR031192; DIS3L.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR033771; Rrp44_CSD1.
DR   InterPro; IPR033770; RRP44_S1.
DR   PANTHER; PTHR23355:SF30; PTHR23355:SF30; 1.
DR   Pfam; PF17849; OB_Dis3; 1.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF17216; Rrp44_CSD1; 1.
DR   Pfam; PF17215; Rrp44_S1; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; SSF50249; 3.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Exonuclease; Exosome; Hydrolase; Magnesium; Nuclease;
KW   Phosphoprotein; Reference proteome; RNA-binding.
FT   CHAIN           1..1054
FT                   /note="DIS3-like exonuclease 1"
FT                   /id="PRO_0000314813"
FT   REGION          313..332
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         989
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TF46"
SQ   SEQUENCE   1054 AA;  120759 MW;  F1294C8EAF98C396 CRC64;
     MLQKREKVLL LRTFQGRTLR IVREHYLRPS VPCNSPLCPQ PATCRNDGKL LSAEVTHYVI
     PDWKVVQDYL EVLEFPELKG IIFMQTACQA VQHQRGRRQY NKLRNLLKDA RHDCVLFANE
     FQQHCYLPRE KGEAMEKWQT RSIYNSAVWY YHHCEDRMPI VMVTEDEEAI QQYGSETEGV
     FVISFKNYLD NFWPDLKAAH ELCDSIIQSR RERESESQET HGKEYPEHLP LEVLEAGIKS
     GRYIQGILNV NKHRAQIEAF VRLQGASSKD SGLVSDILIH GSKARNRSIH GDVVVVELLP
     KSEWKGRTAA LCENDSEDKA SGESPSEPMP TGRVVGILQK NWRDYVVTFP SKEEVQSQGK
     NAQKILVTPW DYRIPKIRIS TQQAEALQDF RVVVRIDSWE TTSVYPNGHF VRVLGRIGDL
     EGEIATILVE NSINVVPFSE AQMCEMPVNT AENPWKVSPK EEQERRDLRS THLVFSIDPK
     GCEDVDDALS VRTLNNGNLE LGVHIADVTH FVAPNSYIDV EARTRATTYY LADRRYDMLP
     SILSADLCSL LGGVDRYAVS VMWELDKTSY EIKKVWYGRT IIRSAYKLFY EAAQELLDGN
     FSIVDDIPEF KTLEEQNRQA KLEELVWAIG KLTDIARHIR AKRDRCGALE LEGVEVRVQL
     DDKKNIHDLI PKQPLEVHET VAECMILANH WVAKKIWESF PHQALLRQHP PPHQEFFSEL
     RECAKAKGFF IDTRSNKTLA DSLDSANDPS DPLVNKLLRS MATQAMSNAL YFSTGSCAEE
     EFHHYGLALD KYTHFTSPIR RYSDIVVHRL LMAAISKDKK VEIKENLFSN KNLEELCRHI
     NNRNRAAQRS QKQSTELFQC MYFKDRDPET EERCVVDGII YSIRTNGVLV FIPRFGIKGA
     AYLKNKDGLV ISCGPEGSSE WKPGSLQRSQ NKIISTTAGG QSVTFHLFDH VTVRISVQPS
     RCHSDMIRLE IVSNKPYMMP NTELCHQSSL LLKSELVKEV TRSVEEAQLA QEVKGKVIEE
     EHQEYRQTKG RSLYTLLEEI RDLALLDVSD SYAM