ID   DI3L1_XENLA             Reviewed;        1040 AA.
AC   Q6GN11;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DIS3-like exonuclease 1;
DE            EC=3.1.13.-;
GN   Name=dis3l;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative cytoplasm-specific catalytic component of the RNA
CC       exosome complex which has 3'->5' exoribonuclease activity and
CC       participates in a multitude of cellular RNA processing and degradation
CC       events. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SUBUNIT: Component of the RNA exosome complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH73711.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC073711; AAH73711.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001086021.1; NM_001092552.1.
DR   AlphaFoldDB; Q6GN11; -.
DR   SMR; Q6GN11; -.
DR   DNASU; 444450; -.
DR   GeneID; 444450; -.
DR   KEGG; xla:444450; -.
DR   CTD; 444450; -.
DR   Xenbase; XB-GENE-1013183; dis3l.L.
DR   OrthoDB; 1104619at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 444450; Expressed in blastula and 19 other tissues.
DR   GO; GO:0000177; C:cytoplasmic exosome (RNase complex); ISS:UniProtKB.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016075; P:rRNA catabolic process; IEA:InterPro.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR041505; Dis3_CSD2.
DR   InterPro; IPR031192; DIS3L.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR033771; Rrp44_CSD1.
DR   PANTHER; PTHR23355:SF30; PTHR23355:SF30; 1.
DR   Pfam; PF17849; OB_Dis3; 1.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF17216; Rrp44_CSD1; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; SSF50249; 3.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Exonuclease; Exosome; Hydrolase; Magnesium; Nuclease;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..1040
FT                   /note="DIS3-like exonuclease 1"
FT                   /id="PRO_0000314815"
SQ   SEQUENCE   1040 AA;  119167 MW;  2683FC790218CB71 CRC64;
     MLKTEKILHL KTQRGRSVRA VREHYLREDV RCGSALCHTC PRDGKLLSEE LTHYVVPDCQ
     VLQDYQEVLE FPELRGIIIM QTACQAVQHQ RGRRQYKKLC SLLRDTRHDC ILFSNEFQNH
     AYLPREMGES ALAWQTRCIY NSCVWYYQHC QKKIPVVMVT EDESVIGKYN TETQEVYVVS
     FQIYLETFWP NFKGALELYK SLRDTHLERK LESRESNGKE YPEHLPLEIL EAGIKSGRYK
     QGVLSVNKHR AQLESFVRLQ GLGGKETDIQ SDIFIHGTKP RNRAIHGDLV AVELLPKSEW
     KGRTGALCEN ETDEKVGDMQ AEVMPTGRVV GIMQRNWRDY VVTFPAKEDT ETQGKNTQKV
     LVMPWDYRIP KIRISTQQAE ALQNYRVVVR IDSWESNSLY PNGHFVRALG RAGNLEAEIA
     TILVENSISL NPFSEAQLAE MPSNTHENPW QVKPEEGDRL DLRETHLVFS IDPKGCEDVD
     DALSIRVLPS GDLELGVHIA DVTHFVQHNT YTDIEARSRA TTYYLADRRN DMLPLILSAD
     LCSLLGAVDR YAVSVIWEMD CSTYEIRRVW YGRTIIRSSY KLSYEVAQQL LDGDLEPLST
     EKELHPLKQD PARLQQLLWA VGKMTEVAHA TRMRRNMSGA LELEGVEVRV QLGEKHSIDD
     LVPKQPLQVH ETIAECMILA NHWVAKKIWE SYPQHALLRL HPPPRQEFFQ ELKECAKARG
     FSIDTRSNKA LADSLDQAHD PSDPLVNQLL RMMATQAMSN ARYFSTGSYT EDEFYHYGLA
     LEKYTHFTSP IRRYADIVVH RLLLAAVNKG PKDHLLGNKD LEELCRHINA RNRAAQQCQK
     QSTELFQCMF FKDKDPDSDQ RCISDAVIYG IRTNGVLLFI PRYGIKGAAY LKNTDGLVLA
     CEEDGQCRWV HGSLQRLPAQ IVVTTQEAKS FSFCLFDHVT VRIRIQSSRF HPDSIRLEII
     SNRPNPSQEA LPSASNPQLL RTELVKEVTR TAVEAQLAVE GAAELKPVER YQEYRQTQGQ
     SLYTMLEELW DLALLDVSGA