ID   DI3L1_XENTR             Reviewed;        1039 AA.
AC   Q0P4R5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=DIS3-like exonuclease 1;
DE            EC=3.1.13.-;
GN   Name=dis3l;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative cytoplasm-specific catalytic component of the RNA
CC       exosome complex which has 3'->5' exoribonuclease activity and
CC       participates in a multitude of cellular RNA processing and degradation
CC       events. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SUBUNIT: Component of the RNA exosome complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI21936.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC121935; AAI21936.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001072835.1; NM_001079367.1.
DR   AlphaFoldDB; Q0P4R5; -.
DR   SMR; Q0P4R5; -.
DR   STRING; 8364.ENSXETP00000034647; -.
DR   PaxDb; Q0P4R5; -.
DR   DNASU; 780296; -.
DR   GeneID; 780296; -.
DR   KEGG; xtr:780296; -.
DR   CTD; 115752; -.
DR   Xenbase; XB-GENE-1013178; dis3l.
DR   eggNOG; KOG2102; Eukaryota.
DR   InParanoid; Q0P4R5; -.
DR   OrthoDB; 1104619at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0000177; C:cytoplasmic exosome (RNase complex); ISS:UniProtKB.
DR   GO; GO:0000178; C:exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016075; P:rRNA catabolic process; IBA:GO_Central.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR041505; Dis3_CSD2.
DR   InterPro; IPR031192; DIS3L.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR033771; Rrp44_CSD1.
DR   PANTHER; PTHR23355:SF30; PTHR23355:SF30; 1.
DR   Pfam; PF17849; OB_Dis3; 1.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF17216; Rrp44_CSD1; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; SSF50249; 3.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Exonuclease; Exosome; Hydrolase; Magnesium; Nuclease;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..1039
FT                   /note="DIS3-like exonuclease 1"
FT                   /id="PRO_0000314816"
SQ   SEQUENCE   1039 AA;  119128 MW;  FCBF334EFADF4684 CRC64;
     MLKTEKILHL KARGRSVRAV REHYLREDVR CGSALCLTCP RDGKLLSEDL THYVVPDCQI
     LQDYLEVLEF PELRGIIIMQ TACQSVQHQR GRRQYKRLCS LLRDTRHDCI LFSNEFQNHA
     YLPREMGESA LAWQTRCIYN SCVWYYQHCQ KKIPVVMVTE DKSVIRQYNT ETQEVYVVSF
     QIYLETFWPN LKGALELYKS LKETHREREL ESREGNGKEY PEHLPLEILE AGIKSGRYQQ
     GVLSVNKHRA QLEGFVRLQG LGGKETDIQS DILIYGTKPR NRAIHGDLVA VELLSRSEWK
     GRNGALCENE TDEKAVDAQA EVMPTGRVVG ILQRNWRDYV ATFPAKEDIE TQGKNAQRVL
     VMPWDYRIPK IRISTQQAEA LQDYRVVVRI DSWESTSLYP NGHFVRVLGR TGNLEAEIAT
     ILVENSISVN PFSEAQLAEM PSNTPESPWQ VKPEEGDRLD LRKTHLVFSI DPKGCEDVDD
     ALSIRKLPSG HLELGVHIAD VTHFVPPNTY TDIEARSRAT TYYLADRRYD MLPLILSADL
     CSLLGGVDRY AVSVIWEMDS STYEIRRVWY GRTIIRSSYK LSYEVAQQLM DGDLEPLNTE
     MELHPLKQDP VRLEQLLWAV GKLTEVAHAT RMRRDMSGAL ELEGVEVRVQ LGEKHSIDDL
     VPKQPLQMHE TIAECMILAN HWVAKKIWEC YPQHALLRLH PPARQEFFQE LKECAKARGF
     SIDTRSNKAL ADSLDQANDP SDPLVNQLLR MMATQAMSNA RYFSTGSYTE DEFYHYGLAL
     EKYTHFTSPI RRYADIVVHR LLLAAVNKGP KDNLLGNKDL EELCRHINVR NRAAQHCQKQ
     STELFQCMFF KDKDPDSDQR CISDAVIYGI RTNGVLLFLP RYGIKGAAYL KNIDGLVLAC
     KDNGRCHWMP GSLQRLPDRI VVTTQEAKSF SYCLFDHVTV RIHVQSSRFH PDSIRLEIIR
     NRPHSSQEAL PSASNPQLAR SELVKEVTRT AVEAQLAVEG AEELKPVEHY QEYRQTQGQS
     LYSMLEELWD LALLDVSGA