ID   DIA1_YEAST              Reviewed;         336 AA.
AC   P54005; D6W0E4;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Protein DIA1;
DE   AltName: Full=Digs into agar protein 1;
GN   Name=DIA1; OrderedLocusNames=YMR316W; ORFNames=YM9924.08;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169872;
RA   Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA   Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA   Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA   Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL   Nature 387:90-93(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   FUNCTION.
RX   PubMed=11063681; DOI=10.1093/genetics/156.3.1005;
RA   Palecek S.P., Parikh A.S., Kron S.J.;
RT   "Genetic analysis reveals that FLO11 upregulation and cell polarization
RT   independently regulate invasive growth in Saccharomyces cerevisiae.";
RL   Genetics 156:1005-1023(2000).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
CC   -!- FUNCTION: Involved in regulation of invasive growth.
CC       {ECO:0000269|PubMed:11063681}.
CC   -!- INTERACTION:
CC       P54005; P39940: RSP5; NbExp=3; IntAct=EBI-27668, EBI-16219;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 736 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; Z54141; CAA90834.1; -; Genomic_DNA.
DR   EMBL; BK006946; DAA10218.1; -; Genomic_DNA.
DR   PIR; S59309; S59309.
DR   RefSeq; NP_014047.1; NM_001182829.1.
DR   AlphaFoldDB; P54005; -.
DR   BioGRID; 35496; 134.
DR   DIP; DIP-4389N; -.
DR   IntAct; P54005; 4.
DR   STRING; 4932.YMR316W; -.
DR   iPTMnet; P54005; -.
DR   MaxQB; P54005; -.
DR   PaxDb; P54005; -.
DR   PRIDE; P54005; -.
DR   EnsemblFungi; YMR316W_mRNA; YMR316W; YMR316W.
DR   GeneID; 855364; -.
DR   KEGG; sce:YMR316W; -.
DR   SGD; S000004935; DIA1.
DR   VEuPathDB; FungiDB:YMR316W; -.
DR   eggNOG; ENOG502S58H; Eukaryota.
DR   GeneTree; ENSGT00940000176746; -.
DR   HOGENOM; CLU_065220_0_0_1; -.
DR   InParanoid; P54005; -.
DR   OMA; LLIHYIE; -.
DR   BioCyc; YEAST:G3O-32981-MON; -.
DR   PRO; PR:P54005; -.
DR   Proteomes; UP000002311; Chromosome XIII.
DR   RNAct; P54005; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0001403; P:invasive growth in response to glucose limitation; IGI:SGD.
DR   GO; GO:0007124; P:pseudohyphal growth; IMP:SGD.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..336
FT                   /note="Protein DIA1"
FT                   /id="PRO_0000203358"
SQ   SEQUENCE   336 AA;  38760 MW;  DCCDF2279AC92297 CRC64;
     MGSISRYLLK KAADGLKDEQ RLKIEMSDSK SVPECFHFNR ERRMPIAEIN GEDGFFMFPS
     QQSLENFENT KKYSNELSPD AIGIPLFQII NCTLPFGKRG HSNTVVGNVP YYKIFKFILR
     TADEPPPYTV AKIVCSNNGL ILYKVPLYDI YKNVSQANVT YSFVGTTSTE PNLLAMAHRE
     GHRDLDTKVN NLNLRWHVTY SPVVTNDHYK LILLADYEVN RLDEDVIRAA KNKMSIDQKD
     QKVQRFVAAH YTREFETSLF RWVAQEGHLI LGEYSTDQGS FGLNNIPPLT EELGCQSLLI
     HYIEYMKRQR KKIAKEARRQ NKRNVANTTN MNMNLM