DIAA_ECO27
ID DIAA_ECO27 Reviewed; 196 AA.
AC B7UJ45;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=DnaA initiator-associating protein DiaA {ECO:0000255|HAMAP-Rule:MF_01157};
GN Name=diaA {ECO:0000255|HAMAP-Rule:MF_01157}; OrderedLocusNames=E2348C_3431;
OS Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=574521;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E2348/69 / EPEC;
RX PubMed=18952797; DOI=10.1128/jb.01238-08;
RA Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R.,
RA Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A.,
RA Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G.;
RT "Complete genome sequence and comparative genome analysis of
RT enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL J. Bacteriol. 191:347-354(2009).
CC -!- FUNCTION: Required for the timely initiation of chromosomal replication
CC via direct interactions with the DnaA initiator protein.
CC {ECO:0000255|HAMAP-Rule:MF_01157}.
CC -!- SUBUNIT: Homotetramer; dimer of dimers. {ECO:0000255|HAMAP-
CC Rule:MF_01157}.
CC -!- SIMILARITY: Belongs to the SIS family. DiaA subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01157}.
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DR EMBL; FM180568; CAS10979.1; -; Genomic_DNA.
DR RefSeq; WP_001158035.1; NC_011601.1.
DR AlphaFoldDB; B7UJ45; -.
DR SMR; B7UJ45; -.
DR EnsemblBacteria; CAS10979; CAS10979; E2348C_3431.
DR GeneID; 66672950; -.
DR KEGG; ecg:E2348C_3431; -.
DR HOGENOM; CLU_080999_3_1_6; -.
DR OMA; DVHICVP; -.
DR Proteomes; UP000008205; Chromosome.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd05006; SIS_GmhA; 1.
DR HAMAP; MF_01157; SIS_DiaA; 1.
DR InterPro; IPR023070; DiaA.
DR InterPro; IPR035461; GmhA/DiaA.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR Pfam; PF13580; SIS_2; 1.
DR SUPFAM; SSF53697; SSF53697; 1.
DR PROSITE; PS51464; SIS; 1.
PE 3: Inferred from homology;
KW DNA replication.
FT CHAIN 1..196
FT /note="DnaA initiator-associating protein DiaA"
FT /id="PRO_1000164293"
FT DOMAIN 34..196
FT /note="SIS"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01157"
SQ SEQUENCE 196 AA; 21090 MW; E1CDFE9C0DF365A8 CRC64;
MQERIKACFT ESIQTQIAAA EALPDAISRA AMTLVQSLLN GNKILCCGNG TSAANAQHFA
ASMINRFETE RPSLPAIALN TDNVVLTAIA NDRLHDEVYA KQVRALGHAG DVLLAISTRG
NSRDIVKAVE AAVTRDMTIV ALTGYDGGEL AGLLGPQDVE IRIPSHRSAR IQEMHMLTVN
CLCDLIDNTL FPHQDV