ID   DIAA_SALG2              Reviewed;         196 AA.
AC   B5REL6;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=DnaA initiator-associating protein DiaA {ECO:0000255|HAMAP-Rule:MF_01157};
GN   Name=diaA {ECO:0000255|HAMAP-Rule:MF_01157}; OrderedLocusNames=SG3157;
OS   Salmonella gallinarum (strain 287/91 / NCTC 13346).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=550538;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=287/91 / NCTC 13346;
RX   PubMed=18583645; DOI=10.1101/gr.077404.108;
RA   Thomson N.R., Clayton D.J., Windhorst D., Vernikos G., Davidson S.,
RA   Churcher C., Quail M.A., Stevens M., Jones M.A., Watson M., Barron A.,
RA   Layton A., Pickard D., Kingsley R.A., Bignell A., Clark L., Harris B.,
RA   Ormond D., Abdellah Z., Brooks K., Cherevach I., Chillingworth T.,
RA   Woodward J., Norberczak H., Lord A., Arrowsmith C., Jagels K., Moule S.,
RA   Mungall K., Saunders M., Whitehead S., Chabalgoity J.A., Maskell D.,
RA   Humphreys T., Roberts M., Barrow P.A., Dougan G., Parkhill J.;
RT   "Comparative genome analysis of Salmonella enteritidis PT4 and Salmonella
RT   gallinarum 287/91 provides insights into evolutionary and host adaptation
RT   pathways.";
RL   Genome Res. 18:1624-1637(2008).
CC   -!- FUNCTION: Required for the timely initiation of chromosomal replication
CC       via direct interactions with the DnaA initiator protein.
CC       {ECO:0000255|HAMAP-Rule:MF_01157}.
CC   -!- SUBUNIT: Homotetramer; dimer of dimers. {ECO:0000255|HAMAP-
CC       Rule:MF_01157}.
CC   -!- SIMILARITY: Belongs to the SIS family. DiaA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01157}.
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DR   EMBL; AM933173; CAR38956.1; -; Genomic_DNA.
DR   RefSeq; WP_000893481.1; NC_011274.1.
DR   AlphaFoldDB; B5REL6; -.
DR   SMR; B5REL6; -.
DR   EnsemblBacteria; CAR38956; CAR38956; SG3157.
DR   GeneID; 66757607; -.
DR   KEGG; seg:SG3157; -.
DR   HOGENOM; CLU_080999_3_1_6; -.
DR   OMA; DVHICVP; -.
DR   Proteomes; UP000008321; Chromosome.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd05006; SIS_GmhA; 1.
DR   HAMAP; MF_01157; SIS_DiaA; 1.
DR   InterPro; IPR023070; DiaA.
DR   InterPro; IPR035461; GmhA/DiaA.
DR   InterPro; IPR001347; SIS_dom.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   Pfam; PF13580; SIS_2; 1.
DR   SUPFAM; SSF53697; SSF53697; 1.
DR   PROSITE; PS51464; SIS; 1.
PE   3: Inferred from homology;
KW   DNA replication.
FT   CHAIN           1..196
FT                   /note="DnaA initiator-associating protein DiaA"
FT                   /id="PRO_1000137798"
FT   DOMAIN          34..196
FT                   /note="SIS"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01157"
SQ   SEQUENCE   196 AA;  21109 MW;  3D5116DB8D03F790 CRC64;
     MLERIKVCFT ESIQTQIAAA EALPDAISRA AMTLVHSLLN GNKILCCGNG TSAANAQHFA
     ASMINRFETE RPSLPAIALN TDNVVLTAIA NDRLHDEVYA KQVRALGHAG DVLLAISTRG
     NSRDIVKAVE AAVTRDMTIV ALTGYDGGEL AGLLGPQDVE IRIPSHHSAR IQEMHMLTVN
     CLCDLIDNTL FPHQDD