ID   DIC1_CANGA              Reviewed;         295 AA.
AC   Q6FTN2;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Mitochondrial dicarboxylate transporter;
DE   AltName: Full=Dicarboxylate carrier 1;
GN   Name=DIC1; OrderedLocusNames=CAGL0G01166g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Mitochondrial dicarboxylic transporter catalyzing the
CC       exchange of dicarboxylic acids like malate and succinate for inorganic
CC       phosphate. Required for growth on ethanol and acetate (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; CR380953; CAG59339.1; -; Genomic_DNA.
DR   RefSeq; XP_446412.1; XM_446412.1.
DR   AlphaFoldDB; Q6FTN2; -.
DR   SMR; Q6FTN2; -.
DR   STRING; 5478.XP_446412.1; -.
DR   EnsemblFungi; CAG59339; CAG59339; CAGL0G01166g.
DR   GeneID; 2888386; -.
DR   KEGG; cgr:CAGL0G01166g; -.
DR   CGD; CAL0130061; CAGL0G01166g.
DR   VEuPathDB; FungiDB:CAGL0G01166g; -.
DR   eggNOG; KOG0759; Eukaryota.
DR   HOGENOM; CLU_015166_14_1_1; -.
DR   InParanoid; Q6FTN2; -.
DR   Proteomes; UP000002428; Chromosome G.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0005310; F:dicarboxylic acid transmembrane transporter activity; IEA:EnsemblFungi.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Antiport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Phosphate transport; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..295
FT                   /note="Mitochondrial dicarboxylate transporter"
FT                   /id="PRO_0000233004"
FT   TRANSMEM        8..24
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..82
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..182
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..280
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          4..88
FT                   /note="Solcar 1"
FT   REPEAT          96..188
FT                   /note="Solcar 2"
FT   REPEAT          198..286
FT                   /note="Solcar 3"
SQ   SEQUENCE   295 AA;  32976 MW;  DAC73A477F826BF5 CRC64;
     MSEKQVKYPW WYGGAAGIFA VMNTHPLDLT KVRLQAAPIP KPTIVQMLRS ILKNEGIVGL
     YAGLSASLLR QCTYTTARFG MYDALKEHVI PRDKLTNMWY LLGASMVSGA LGGLAGNFAD
     LINIRMQNDS ALPLDKRRNY KNAIDGMVKI YKAEGAKSLF LTGWKPNMVR GVLMTASQVV
     TYDMFKNFLV TKYNMDPKKN STHLTSSLLA GFVATTVCSP ADVIKTIVMN AHKKPGHNHD
     SSFKILMEAI NKEGPSFMFR GWVPSFTRLA PFTMLIFFAM EQLKKYRVGM PKEEA