DIC1_SCHPO
ID DIC1_SCHPO Reviewed; 544 AA.
AC O94518;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Dynein intermediate chain 1;
DE AltName: Full=Meiotically up-regulated gene 44 protein;
GN Name=dic1; Synonyms=mug44; ORFNames=SPBC646.17c, SPBC855.01c, SPBP35G2.01c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=15509865; DOI=10.1242/jcs.01475;
RA Niccoli T., Yamashita A., Nurse P., Yamamoto M.;
RT "The p150-Glued Ssm4p regulates microtubular dynamics and nuclear movement
RT in fission yeast.";
RL J. Cell Sci. 117:5543-5556(2004).
RN [3]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in meiotic nuclear divsion where it promotes the
CC movement of 'horsetails'. {ECO:0000269|PubMed:15509865,
CC ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC {ECO:0000305}.
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DR EMBL; CU329671; CAA22821.2; -; Genomic_DNA.
DR PIR; T40593; T40593.
DR RefSeq; XP_001713125.1; XM_001713073.2.
DR AlphaFoldDB; O94518; -.
DR SMR; O94518; -.
DR BioGRID; 857895; 1.
DR STRING; 4896.SPBC646.17c.1; -.
DR PaxDb; O94518; -.
DR EnsemblFungi; SPBC646.17c.1; SPBC646.17c.1:pep; SPBC646.17c.
DR PomBase; SPBC646.17c; dic1.
DR VEuPathDB; FungiDB:SPBC646.17c; -.
DR eggNOG; KOG1587; Eukaryota.
DR HOGENOM; CLU_500736_0_0_1; -.
DR InParanoid; O94518; -.
DR OMA; YVRDYTI; -.
DR PhylomeDB; O94518; -.
DR Reactome; R-SPO-9646399; Aggrephagy.
DR PRO; PR:O94518; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0030981; C:cortical microtubule cytoskeleton; IDA:PomBase.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0035974; C:meiotic spindle pole body; IDA:PomBase.
DR GO; GO:0045504; F:dynein heavy chain binding; IBA:GO_Central.
DR GO; GO:0045503; F:dynein light chain binding; IBA:GO_Central.
DR GO; GO:0030989; P:dynein-driven meiotic oscillatory nuclear movement; IMP:PomBase.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0010970; P:transport along microtubule; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Meiosis; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..544
FT /note="Dynein intermediate chain 1"
FT /id="PRO_0000297693"
FT REPEAT 241..281
FT /note="WD 1"
FT REPEAT 289..330
FT /note="WD 2"
FT REPEAT 342..387
FT /note="WD 3"
FT REPEAT 402..441
FT /note="WD 4"
FT REPEAT 461..501
FT /note="WD 5"
FT REPEAT 506..544
FT /note="WD 6"
SQ SEQUENCE 544 AA; 60961 MW; 1057A3C5435F3E6D CRC64;
MDKNIKREIE IKRAKLLLLK NKENCTDAVS SSNKEGPKQI SEDQLSNFLC KILKPTNLTP
QTYSLESKSS NLVSDCELKI SSVYQSYSST FNVSNHVPSI SKTVNIRETS KHLKHSTKAP
KCSLPTSALE IDHLNNFLHS SAKILDRALC DQSNQLFTDY TVKKKSKKNK SQLEENGLNH
LFTFQDEKIT LNSVVNSISY SSFFEELLIT SYAKPKEALR TRGLAIVWNQ RWKNSPESVL
KARSEITVCK PSPFHPQLIA GGAYNGQVFL WDLRQGQYPV SFTTIISGGH LEPVTDITYI
NNPPSNNIVT CSTDGLVHIW EPDMFSRPSE TICLSSQVDS SSQCIPATCL SFIPENNMEF
LVGAEDGKLQ RGYRSDYSET KAVQPSNVSY EGHNVFISGI DVMTSNSQNV FLEKNKDFAL
TSSFDWTVRL WQCSPSRNQH ELVPSNDLDE QVIINSCKTF THKAMVFDVK WCVSEPCCFA
SVDALGNLNL WDLQKDVEAP VTSDIPDGKP LNKIAWQPEK RNLACGGLNG NVHIYKHLSP
NLAN
