DICA_ECOLI
ID DICA_ECOLI Reviewed; 135 AA.
AC P06966;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=HTH-type transcriptional regulator DicA;
DE AltName: Full=Repressor protein of division inhibition gene dicA;
GN Name=dicA; OrderedLocusNames=b1570, JW1562;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3532030; DOI=10.1093/nar/14.17.6821;
RA Bejar S., Cam K., Bouche J.-P.;
RT "Control of cell division in Escherichia coli. DNA sequence of dicA and of
RT a second gene complementing mutation dicA1, dicC.";
RL Nucleic Acids Res. 14:6821-6833(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA Wada C., Yamamoto Y., Horiuchi T.;
RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 28.0-40.1 min region on the linkage map.";
RL DNA Res. 3:363-377(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-79.
RX PubMed=2836697; DOI=10.1007/bf00322439;
RA Bejar S., Bouche F., Bouche J.-P.;
RT "Cell division inhibition gene dicB is regulated by a locus similar to
RT lambdoid bacteriophage immunity loci.";
RL Mol. Gen. Genet. 212:11-19(1988).
CC -!- FUNCTION: This protein is a repressor of division inhibition gene dicB.
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DR EMBL; X07465; CAA30349.1; -; Genomic_DNA.
DR EMBL; U00096; AAC74643.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15275.1; -; Genomic_DNA.
DR PIR; S05260; BVECDA.
DR RefSeq; NP_416088.1; NC_000913.3.
DR RefSeq; WP_000448564.1; NZ_LN832404.1.
DR AlphaFoldDB; P06966; -.
DR SMR; P06966; -.
DR IntAct; P06966; 5.
DR STRING; 511145.b1570; -.
DR jPOST; P06966; -.
DR PaxDb; P06966; -.
DR PRIDE; P06966; -.
DR EnsemblBacteria; AAC74643; AAC74643; b1570.
DR EnsemblBacteria; BAA15275; BAA15275; BAA15275.
DR GeneID; 66674538; -.
DR GeneID; 946241; -.
DR KEGG; ecj:JW1562; -.
DR KEGG; eco:b1570; -.
DR PATRIC; fig|1411691.4.peg.693; -.
DR EchoBASE; EB0222; -.
DR eggNOG; COG1396; Bacteria.
DR HOGENOM; CLU_066192_4_4_6; -.
DR InParanoid; P06966; -.
DR OMA; NETSETC; -.
DR PhylomeDB; P06966; -.
DR BioCyc; EcoCyc:EG10226-MON; -.
DR PRO; PR:P06966; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003677; F:DNA binding; IDA:EcoCyc.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IDA:EcoCyc.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR Pfam; PF01381; HTH_3; 1.
DR SMART; SM00530; HTH_XRE; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
PE 4: Predicted;
KW Cell cycle; Cell division; DNA-binding; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..135
FT /note="HTH-type transcriptional regulator DicA"
FT /id="PRO_0000149725"
FT DOMAIN 12..66
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT DNA_BIND 23..42
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
SQ SEQUENCE 135 AA; 15656 MW; F95F3BB666D6C6B5 CRC64;
METKNLTIGE RIRYRRKNLK HTQRSLAKAL KISHVSVSQW ERGDSEPTGK NLFALSKVLQ
CSPTWILFGD EDKQPTPPVE KPVALSPKEL ELLELFNALP ESEQDTQLAE MRARVKNFNK
LFEELLKARQ RTNKR
