DICB_DICDI
ID DICB_DICDI Reviewed; 607 AA.
AC Q55GS3; Q7YZT1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Discoidin-inducing complex subunit B;
DE Flags: Precursor;
GN Name=dicB; ORFNames=DDB_G0267470;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF N-TERMINUS, PROTEIN
RP SEQUENCE OF 232-239 AND 485-493, SUBCELLULAR LOCATION, AND INTERACTION WITH
RP PSIF.
RX PubMed=15947191; DOI=10.1128/ec.4.6.991-998.2005;
RA Kolbinger A., Gao T., Brock D., Ammann R., Kisters A., Kellermann J.,
RA Hatton D., Gomer R.H., Wetterauer B.;
RT "A cysteine-rich extracellular protein containing a PA14 domain mediates
RT quorum sensing in Dictyostelium discoideum.";
RL Eukaryot. Cell 4:991-998(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of a complex that acts as a quorum sensing protein
CC regulating discoidin gene expression during growth and development. Its
CC function in the complex is unclear as it has no ability to induce
CC discoidin during growth and development by itself.
CC -!- SUBUNIT: Forms a complex with psiF/dicA.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:15947191}.
CC -!- MISCELLANEOUS: According to PubMed:15947191, it is secreted in the
CC conditioned medium. However, prediction tools clearly predict a
CC transmembrane domain. In some conditions, it may be cleaved and
CC secreted in the conditioned medium, which would explain the
CC discrepancy.
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DR EMBL; AJ548836; CAD69023.1; -; mRNA.
DR EMBL; AAFI02000003; EAL73188.1; -; Genomic_DNA.
DR RefSeq; XP_647111.1; XM_642019.1.
DR AlphaFoldDB; Q55GS3; -.
DR STRING; 44689.DDB0191200; -.
DR PaxDb; Q55GS3; -.
DR EnsemblProtists; EAL73188; EAL73188; DDB_G0267470.
DR GeneID; 8615915; -.
DR KEGG; ddi:DDB_G0267470; -.
DR dictyBase; DDB_G0267470; dicB.
DR eggNOG; ENOG502RFIG; Eukaryota.
DR HOGENOM; CLU_450121_0_0_1; -.
DR InParanoid; Q55GS3; -.
DR OMA; MRNSIAN; -.
DR PhylomeDB; Q55GS3; -.
DR PRO; PR:Q55GS3; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005576; C:extracellular region; IDA:dictyBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030587; P:sorocarp development; HMP:dictyBase.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Glycoprotein; Membrane; Reference proteome;
KW Secreted; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000269|PubMed:15947191"
FT CHAIN 20..607
FT /note="Discoidin-inducing complex subunit B"
FT /id="PRO_5000070596"
FT TOPO_DOM 20..554
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 555..575
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 576..607
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 215
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 277
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 307
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 324
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 453
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 477
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 527
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 538
FT /note="C -> L (in Ref. 1; CAD69023)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 607 AA; 65169 MW; 6596BC2FF65FED40 CRC64;
MNKKIIILIY LIFIKSIVGQ NPVWIGGSGC NLFTDSSCWS PSTSPLTTDI VTMGVDSTQT
VVDGDITITT LINNNLTLGG VEMSSTISLE IIDTSLIVSG AFSMATNSRL SLSLSDSYAN
SLVSGSATRN AVNVLMNLQS MQTLMVGSSF TMTGNSVLDV NRSISTINGV FTMNDDTSLF
MYSKQNGDSK FTVGNSVLND ASSLNFQGQS FIFFNQTNLP SGLVLNDQSK IVAIDADNVK
ISGVVTLNDQ SSIQLTSSRL YLDSLVTATT SSILVNNSTL SILQSIPTTF SPASAVFKGS
VFTIKSNCTI QSPITMIDSV YSFNQSHTLA SQFTGSNVYM IMDAAILNAG NYYDCSGCSL
SMRNSIANFD SYENQGDLIL SSSKLNSNAP ITSNTGSIFG YYGELNQALT VESGSLGVYN
EKTRLFVNGN VIVESGAKIQ FYLSSPLDFS WLNTSGSLDV QSGTIIEIYV YIEILNNGSM
EVIKTSNGFV TPLSTDNVKL YTYDPDNDVI TDFSTTGGCE YSISITNTSV LVHTDYACQQ
AIITLGTDGI SKGSLAGISV SMVALACFVS LGVWWKTSKK NDQRNDSQVL TNFSQNKSDD
IDVERKL
