DICH_DROME
ID DICH_DROME Reviewed; 382 AA.
AC Q24533; A2VED6; Q8MSP8; Q9VUD4;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=SOX domain-containing protein dichaete;
DE AltName: Full=Protein fish-hook;
GN Name=D; Synonyms=fish, Sox70D; ORFNames=CG5893;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=8951062; DOI=10.1242/dev.122.11.3467;
RA Nambu P.A., Nambu J.R.;
RT "The Drosophila fish-hook gene encodes a HMG domain protein essential for
RT segmentation and CNS development.";
RL Development 122:3467-3475(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, AND DISRUPTION PHENOTYPE.
RC STRAIN=Oregon-R; TISSUE=Embryo;
RX PubMed=8951082; DOI=10.1242/dev.122.11.3669;
RA Russell S.R.H., Sanchez-Soriano N., Wright C.R., Ashburner M.;
RT "The Dichaete gene of Drosophila melanogaster encodes a SOX-domain protein
RT required for embryonic segmentation.";
RL Development 122:3669-3676(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kapadia B., Kronmiller B., Li P.W., Liao G.,
RA Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S.,
RA Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M.,
RA Celniker S.E.;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential for segmentation and CNS development. May modulate
CC the actions of other transcription factors, including gap and pair-rule
CC proteins. {ECO:0000269|PubMed:8951062, ECO:0000269|PubMed:8951082}.
CC -!- INTERACTION:
CC Q24533; Q7JR80: CG3884; NbExp=4; IntAct=EBI-147892, EBI-15108203;
CC Q24533; Q8I942: Dmel\CG32846; NbExp=4; IntAct=EBI-147892, EBI-15112591;
CC Q24533; Q8INY5: Dmel\CG5674; NbExp=4; IntAct=EBI-147892, EBI-15139688;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- TISSUE SPECIFICITY: Initially expressed in a pair-rule-like pattern
CC which is rapidly replaced by strong neuroectoderm expression.
CC {ECO:0000269|PubMed:8951062, ECO:0000269|PubMed:8951082}.
CC -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis.
CC {ECO:0000269|PubMed:8951062, ECO:0000269|PubMed:8951082}.
CC -!- DISRUPTION PHENOTYPE: Flies exhibit severe segmentation defects,
CC including loss and/or fusion of abdominal denticle belts and stripe-
CC specific defects in pair-rule and segment polarity gene expression.
CC Mutant embryos also exhibit loss of specific neurons, fusion of
CC adjacent ventral nerve cord ganglia and aberrant axon scaffold
CC organization. {ECO:0000269|PubMed:8951062, ECO:0000269|PubMed:8951082}.
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DR EMBL; U68056; AAB49673.1; -; mRNA.
DR EMBL; X96419; CAA65279.1; -; mRNA.
DR EMBL; AE014296; AAF49753.1; -; Genomic_DNA.
DR EMBL; AY118670; AAM50530.1; -; mRNA.
DR EMBL; BT030105; ABN49244.1; -; mRNA.
DR RefSeq; NP_001261830.1; NM_001274901.1.
DR RefSeq; NP_001261831.1; NM_001274902.1.
DR RefSeq; NP_001261832.1; NM_001274903.1.
DR RefSeq; NP_524066.1; NM_079342.3.
DR AlphaFoldDB; Q24533; -.
DR SMR; Q24533; -.
DR BioGRID; 64905; 33.
DR DIP; DIP-21577N; -.
DR IntAct; Q24533; 37.
DR STRING; 7227.FBpp0075488; -.
DR PaxDb; Q24533; -.
DR DNASU; 39570; -.
DR EnsemblMetazoa; FBtr0075746; FBpp0075488; FBgn0000411.
DR EnsemblMetazoa; FBtr0333034; FBpp0305248; FBgn0000411.
DR EnsemblMetazoa; FBtr0333035; FBpp0305249; FBgn0000411.
DR EnsemblMetazoa; FBtr0333036; FBpp0305250; FBgn0000411.
DR GeneID; 39570; -.
DR KEGG; dme:Dmel_CG5893; -.
DR FlyBase; FBgn0000411; D.
DR VEuPathDB; VectorBase:FBgn0000411; -.
DR eggNOG; KOG0527; Eukaryota.
DR HOGENOM; CLU_021123_1_0_1; -.
DR InParanoid; Q24533; -.
DR OMA; HQSSGMH; -.
DR OrthoDB; 1207943at2759; -.
DR PhylomeDB; Q24533; -.
DR Reactome; R-DME-3769402; Deactivation of the beta-catenin transactivating complex.
DR SignaLink; Q24533; -.
DR BioGRID-ORCS; 39570; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 39570; -.
DR PRO; PR:Q24533; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0000411; Expressed in anlage in statu nascendi and 81 other tissues.
DR ExpressionAtlas; Q24533; baseline and differential.
DR Genevisible; Q24533; DM.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0003677; F:DNA binding; IDA:FlyBase.
DR GO; GO:0008301; F:DNA binding, bending; IDA:FlyBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:FlyBase.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IDA:FlyBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0008134; F:transcription factor binding; IPI:FlyBase.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IMP:FlyBase.
DR GO; GO:0007350; P:blastoderm segmentation; IMP:FlyBase.
DR GO; GO:0007420; P:brain development; IMP:FlyBase.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0007417; P:central nervous system development; IMP:FlyBase.
DR GO; GO:0070983; P:dendrite guidance; IMP:FlyBase.
DR GO; GO:0009950; P:dorsal/ventral axis specification; IMP:FlyBase.
DR GO; GO:0007442; P:hindgut morphogenesis; IMP:FlyBase.
DR GO; GO:0002168; P:instar larval development; IMP:FlyBase.
DR GO; GO:0060810; P:intracellular mRNA localization involved in pattern specification process; IMP:FlyBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0014019; P:neuroblast development; IMP:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:FlyBase.
DR GO; GO:0035120; P:post-embryonic appendage morphogenesis; IMP:FlyBase.
DR GO; GO:0010468; P:regulation of gene expression; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:FlyBase.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..382
FT /note="SOX domain-containing protein dichaete"
FT /id="PRO_0000048802"
FT DNA_BIND 142..210
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 53..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 127
FT /note="Missing (in Ref. 5; AAM50530)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 382 AA; 40212 MW; B03A267F9230A054 CRC64;
MATLSTHPNY GFHLGQAQGL EDYAPQSQLQ LSPGMDMDIK RVLHYSQSLA AMGGSPNGPA
GQGVNGSSGM GHHMSSHMTP HHMHQAVSAQ QTLSPNSSIG SAGSLGSQSS LGSNGSGLNS
SSGHQSAGMH SLATSPGQEG HIKRPMNAFM VWSRLQRRQI AKDNPKMHNS EISKRLGAEW
KLLAESEKRP FIDEAKRLRA LHMKEHPDYK YRPRRKPKNP LTAGPQGGLQ MQAGGMGQQK
LGAGPGAGAG GYNPFHQLPP YFAPSHHLDQ GYPVPYFGGF DPLALSKLHQ SQAAAAAAVN
NQGQQQGQAP PQLPPTSLSS FYSGIYSGIS APSLYAAHSA NAAGLYPSSS TSSPGSSPGT
ITPNGMDGSM DSALRRPVPV LY
