位置:首页 > 蛋白库 > DID5_CERCE
DID5_CERCE
ID   DID5_CERCE              Reviewed;          65 AA.
AC   P83041; P83042;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   29-AUG-2001, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Disintegrin CC5;
DE   Contains:
DE     RecName: Full=Disintegrin CC5B;
OS   Cerastes cerastes (Horned desert viper).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Viperinae; Cerastes.
OX   NCBI_TaxID=8697;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=11827548; DOI=10.1021/bi015627o;
RA   Calvete J.J., Fox J.W., Agelan A., Niewiarowski S., Marcinkiewicz C.;
RT   "The presence of the WGD motif in CC8 heterodimeric disintegrin increases
RT   its inhibitory effect on alphaII(b)beta3, alpha(v)beta3, and alpha5beta1
RT   integrins.";
RL   Biochemistry 41:2014-2021(2002).
CC   -!- FUNCTION: Binds and inhibits integrins alpha-IIb/beta-3 (ITGA2B/ITGB3),
CC       alpha-V/beta-3 (ITGAV/ITGB3) and alpha-5/beta-1 (ITGA5/ITGB1).
CC   -!- SUBUNIT: Homodimer; disulfide-linked.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the disintegrin family. Dimeric disintegrin
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P83041; -.
DR   SMR; P83041; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   Pfam; PF00200; Disintegrin; 1.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion; Cell adhesion impairing toxin; Direct protein sequencing;
KW   Disulfide bond; Secreted; Toxin.
FT   CHAIN           1..65
FT                   /note="Disintegrin CC5"
FT                   /id="PRO_0000045876"
FT   CHAIN           2..65
FT                   /note="Disintegrin CC5B"
FT                   /id="PRO_0000045877"
FT   DOMAIN          1..65
FT                   /note="Disintegrin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   MOTIF           43..45
FT                   /note="Cell attachment site"
FT   DISULFID        7..30
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   DISULFID        8
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   DISULFID        13
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   DISULFID        21..27
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   DISULFID        26..51
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   DISULFID        39..58
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
SQ   SEQUENCE   65 AA;  7158 MW;  558BDF91EDA596E8 CRC64;
     MNSAHPCCDP VTCKPKRGEH CISGPCCRNC KFLSPGTICK KARGDDMNDY CTGISSDCPR
     NRYKS
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024