ID   DID8A_CERCE             Reviewed;          65 AA.
AC   P83043;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   29-AUG-2001, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Disintegrin CC8A;
OS   Cerastes cerastes (Horned desert viper).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Viperinae; Cerastes.
OX   NCBI_TaxID=8697;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=11827548; DOI=10.1021/bi015627o;
RA   Calvete J.J., Fox J.W., Agelan A., Niewiarowski S., Marcinkiewicz C.;
RT   "The presence of the WGD motif in CC8 heterodimeric disintegrin increases
RT   its inhibitory effect on alphaII(b)beta3, alpha(v)beta3, and alpha5beta1
RT   integrins.";
RL   Biochemistry 41:2014-2021(2002).
CC   -!- FUNCTION: Inhibits integrins alpha-IIb/beta-3 (ITGA2B/ITGB3), alpha-
CC       V/beta-3 (ITGAV/ITGB3), and alpha-5/beta-1 (ITGA5/ITGB1).
CC   -!- SUBUNIT: Heterodimer with CC8B; disulfide-linked.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the disintegrin family. Dimeric disintegrin
CC       subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P83043; -.
DR   SMR; P83043; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   Pfam; PF00200; Disintegrin; 1.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion; Cell adhesion impairing toxin; Direct protein sequencing;
KW   Disulfide bond; Secreted; Toxin.
FT   CHAIN           1..65
FT                   /note="Disintegrin CC8A"
FT                   /id="PRO_0000101788"
FT   DOMAIN          1..65
FT                   /note="Disintegrin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   MOTIF           43..45
FT                   /note="Cell attachment site"
FT   DISULFID        7..30
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   DISULFID        8
FT                   /note="Interchain (with CC8B)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   DISULFID        13
FT                   /note="Interchain (with CC8B)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   DISULFID        21..27
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   DISULFID        26..51
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   DISULFID        39..58
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
SQ   SEQUENCE   65 AA;  7149 MW;  430BC491EDA596E8 CRC64;
     MNSAHPCCDP VTCKPKRGEH CISGPCCRNC KFLSPGTICK KARGDDMNDY CTGISSDCPR
     NRIKK