DIDLB_ECHCA
ID DIDLB_ECHCA Reviewed; 63 AA.
AC P0C6B5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 1.
DT 25-MAY-2022, entry version 47.
DE RecName: Full=Disintegrin schistatin-like subunit B;
OS Echis carinatus (Saw-scaled viper).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Viperinae; Echis.
OX NCBI_TaxID=40353;
RN [1]
RP PROTEIN SEQUENCE, SUBUNIT, X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS), AND
RP DISULFIDE BONDS.
RC TISSUE=Venom;
RX PubMed=16101289; DOI=10.1021/bi050849y;
RA Bilgrami S., Yadav S., Kaur P., Sharma S., Perbandt M., Betzel C.,
RA Singh T.P.;
RT "Crystal structure of the disintegrin heterodimer from saw-scaled viper
RT (Echis carinatus) at 1.9 A resolution.";
RL Biochemistry 44:11058-11066(2005).
CC -!- FUNCTION: May bind to both alpha-IIb/beta-3 (ITGA2B/ITGB3) and alpha-
CC V/beta-3 (ITGAV/ITGB3) integrins, and may inhibit platelet aggregation.
CC {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer with subunit A; disulfide-linked.
CC {ECO:0000269|PubMed:16101289}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the disintegrin family. Dimeric disintegrin
CC subfamily. {ECO:0000305}.
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DR PDB; 1TEJ; X-ray; 1.90 A; B=1-63.
DR PDBsum; 1TEJ; -.
DR AlphaFoldDB; P0C6B5; -.
DR SMR; P0C6B5; -.
DR EvolutionaryTrace; P0C6B5; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR Gene3D; 4.10.70.10; -; 1.
DR InterPro; IPR018358; Disintegrin_CS.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR Pfam; PF00200; Disintegrin; 1.
DR PRINTS; PR00289; DISINTEGRIN.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; SSF57552; 1.
DR PROSITE; PS00427; DISINTEGRIN_1; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell adhesion impairing toxin; Direct protein sequencing;
KW Disulfide bond; Hemostasis impairing toxin;
KW Platelet aggregation inhibiting toxin; Secreted; Toxin.
FT CHAIN 1..63
FT /note="Disintegrin schistatin-like subunit B"
FT /id="PRO_0000319470"
FT DOMAIN 1..63
FT /note="Disintegrin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT MOTIF 42..44
FT /note="Cell attachment site"
FT DISULFID 6..29
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00068,
FT ECO:0000269|PubMed:16101289"
FT DISULFID 7
FT /note="Interchain (with C-11 in subunit A)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00068,
FT ECO:0000269|PubMed:16101289"
FT DISULFID 12
FT /note="Interchain (with C-6 in subunit A)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00068,
FT ECO:0000269|PubMed:16101289"
FT DISULFID 20..26
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00068,
FT ECO:0000269|PubMed:16101289"
FT DISULFID 25..50
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00068,
FT ECO:0000269|PubMed:16101289"
FT DISULFID 38..57
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00068,
FT ECO:0000269|PubMed:16101289"
FT TURN 9..11
FT /evidence="ECO:0007829|PDB:1TEJ"
FT STRAND 12..14
FT /evidence="ECO:0007829|PDB:1TEJ"
FT STRAND 21..23
FT /evidence="ECO:0007829|PDB:1TEJ"
FT STRAND 37..39
FT /evidence="ECO:0007829|PDB:1TEJ"
FT STRAND 42..45
FT /evidence="ECO:0007829|PDB:1TEJ"
SQ SEQUENCE 63 AA; 6961 MW; 15996A964A6A0CE0 CRC64;
NSVNPCCDPQ TCKPIEGKHC ISGPCCENCY FLRSGTICQR ARGDGNNDYC TGITPDCPRN
RYN