ADBP1_CAEEL
ID ADBP1_CAEEL Reviewed; 217 AA.
AC G5EDW1;
DT 31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Adr-2-binding protein 1 {ECO:0000303|PubMed:18780728};
GN Name=adbp-1 {ECO:0000312|WormBase:VW02B12L.4};
GN Synonyms=2L737 {ECO:0000312|EMBL:AAG50214.1};
GN ORFNames=VW02B12L.4 {ECO:0000312|WormBase:VW02B12L.4};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000312|EMBL:AAG50214.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Bristol N2 {ECO:0000312|EMBL:AAG50214.1};
RA Kohara Y., Shin'i T., Suzuki Y., Sugano S., Potdevin M., Thierry-Mieg Y.,
RA Thierry-Mieg D., Thierry-Mieg J.;
RT "The Caenorhabditis elegans transcriptome project, a complementary view of
RT the genome.";
RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP FUNCTION, INTERACTION WITH ADR-2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP DEVELOPMENTAL STAGE, AND MUTAGENESIS OF 119-GLN--CYS-217.
RX PubMed=18780728; DOI=10.1534/genetics.108.093310;
RA Ohta H., Fujiwara M., Ohshima Y., Ishihara T.;
RT "ADBP-1 regulates an ADAR RNA-editing enzyme to antagonize RNA-
RT interference-mediated gene silencing in Caenorhabditis elegans.";
RL Genetics 180:785-796(2008).
CC -!- FUNCTION: Required for the A-I editing activity of the double-stranded
CC RNA-specific adenosine deaminase adr-2 by facilitating adr-2 nuclear
CC localization. {ECO:0000269|PubMed:18780728}.
CC -!- SUBUNIT: Interacts with double-stranded RNA-specific adenosine
CC deaminase adr-2. {ECO:0000269|PubMed:18780728}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18780728}.
CC -!- TISSUE SPECIFICITY: Expressed in main body hypodermal cells, the
CC hypodermal seam cells, pharynx, intestine and some neurons.
CC {ECO:0000269|PubMed:18780728}.
CC -!- DEVELOPMENTAL STAGE: Expression starts in the embryo and continues
CC through young adulthood with lower levels in older adults.
CC {ECO:0000269|PubMed:18780728}.
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DR EMBL; AF303256; AAG50214.1; -; mRNA.
DR EMBL; BX284602; CAA20335.2; -; Genomic_DNA.
DR PIR; T18566; T18566.
DR RefSeq; NP_496439.1; NM_064038.7.
DR AlphaFoldDB; G5EDW1; -.
DR SMR; G5EDW1; -.
DR IntAct; G5EDW1; 1.
DR STRING; 6239.VW02B12L.4; -.
DR EPD; G5EDW1; -.
DR PaxDb; G5EDW1; -.
DR PeptideAtlas; G5EDW1; -.
DR EnsemblMetazoa; VW02B12L.4.1; VW02B12L.4.1; WBGene00012157.
DR GeneID; 174745; -.
DR KEGG; cel:CELE_VW02B12L.4; -.
DR CTD; 174745; -.
DR WormBase; VW02B12L.4; CE26728; WBGene00012157; adbp-1.
DR eggNOG; ENOG502THRE; Eukaryota.
DR HOGENOM; CLU_1273281_0_0_1; -.
DR InParanoid; G5EDW1; -.
DR OMA; SRENWGM; -.
DR OrthoDB; 1564913at2759; -.
DR PRO; PR:G5EDW1; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00012157; Expressed in embryo and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:1900182; P:positive regulation of protein localization to nucleus; IMP:UniProtKB.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..217
FT /note="Adr-2-binding protein 1"
FT /id="PRO_0000442983"
FT REGION 33..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 119..217
FT /note="Missing: In qj1: Causes transgene silencing in
FT hypodermal and intestinal cells but does not appear to
FT markedly affect transgenes expressed in muscles or neurons.
FT Abolishes A-to-I RNA editing of known substrates. Reduced
FT nuclear localization of adr-2. Does not affect fertility."
FT /evidence="ECO:0000269|PubMed:18780728"
SQ SEQUENCE 217 AA; 23955 MW; 74DF36B1579C4D20 CRC64;
MSFASGCTPV SFDKLFEVSS GDKVSRENWG MIARPEPQHD SLKRRNTTSS IAKKKAKMTR
GDEQITDETA RKAATQLLDQ IQDTPGRISL NFETPEAASV CPIPTSLNQI VNTKWTVNQL
QEGQLTMLLA QDANKFKSLG VKNIKKGSVE TQILPRQMDV KEIVEKLKKQ DNDSDQFVGY
AAAVANVLRR CDAETAQKIT QAITATIEKE APSIVNC
